HitPredict

Interactor 1: NHR49 (O45666)
Nuclear hormone receptor family member nhr-49
Gene: nhr-49

Interactor 2: Q9NAJ3 (Q9NAJ3)
Nuclear receptor domain-containing protein
Gene: nhr-234

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.904

Property	Details
Experiments	19123269, 23791784, 22511885, 14704431
Identification Methods	two hybrid, two hybrid array, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Hormone_recep~zf-C4, zf-C4~zf-C4
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 501 Ce			1 357
+	Ce
		108377 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		G5EGP2_CAEEL (4-351): 1.19e-113: 335: 33.52
+	Ce
		220319 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR49_CAEEL (7-357): 1.34e-88: 276: 16.54
+	Ce
		220333 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		Q19438_CAEEL (7-350): 1.34e-86: 267: 29.05
+	Ce
		106951 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NH114_CAEEL (1-352): 5.17e-85: 265: 17.13
+	Ce
		220087 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		O45507_CAEEL (11-350): 3.86e-85: 263: 33.52
+	Ce
		184860 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NH169_CAEEL (6-350): 1.09e-83: 259: 34.96
+	Ce
		184317 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		O17020_CAEEL (32-352): 8.18e-83: 256: 39.18
+	Ce
		184019 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		O16537_CAEEL (12-350): 1.33e-81: 253: 28.99
+	Ce
		184020 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		O16538_CAEEL (7-349): 2.69e-81: 252: 28.86
+	Ce
		220327 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR20_CAEEL (9-357): 2.25e-77: 246: 25.06
+	Hs
		782496 HNF4A_HUMAN (5-495): 7.48e-107: 328: 27.80		HNF4A_HUMAN (6-357): 3.74e-96: 295: 16.25
+	Mm
		659690 RXRA_MOUSE (1-423): 7.87e-106: 325: 27.66		NR1H3_MOUSE (2-352): 1.82e-92: 285: 17.93
+	Hs
		368969 RXRA_HUMAN (1-423): 1.18e-104: 322: 27.66		ESR1_HUMAN (6-354): 9.81e-91: 285: 16.71
+	Hs
		500354 RXRA_HUMAN (1-423): 1.18e-104: 322: 27.66		RARB_HUMAN (11-351): 6.83e-87: 271: 18.21
+	Hs
		490049 RXRA_HUMAN (1-423): 1.18e-104: 322: 27.66		NR2F6_HUMAN (2-325): 4.88e-87: 270: 20.48
+	Mm
		659674 RXRA_MOUSE (1-423): 7.87e-106: 325: 27.66		THB_MOUSE (8-351): 1.29e-84: 265: 16.57
+	Ce
		106935 H2KZA1_CAEEL (14-483): 6.33e-103: 322: 28.78		NH114_CAEEL (1-352): 5.17e-85: 265: 17.13
+	Ce
		220349 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR71_CAEEL (11-108): 8.48e-17: 83.6: 39.80
+	Ce
		220328 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR22_CAEEL (2-94): 2.82e-16: 82: 42.86
+	Ce
		220343 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		Q86PI8_CAEEL (5-88): 1.73e-15: 77.8: 38.10