Protein: CBLB
E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)

Gene: CBLB
Organism: Mus musculus
Interactions: 70
UniProt ID: Q3TTA7

Gene Ontology (top 5):
GO:0001784 - phosphotyrosine residue binding
GO:0002669 - positive regulation of T cell anergy
GO:0002870 - T cell anergy
GO:0004842 - ubiquitin-protein transferase activity
GO:0005509 - calcium ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

509053

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]

2

8

Small-scale

0.778

High

1189570

CBLB
E3 ubiquitin-protein ligase CBL-B

2

11

Small-scale

0.768

High

651520

CBL
E3 ubiquitin-protein ligase CBL

2

11

Small-scale

0.737

High

957270

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

11

Small-scale

0.647

High

648050

MYD88
Myeloid differentiation primary response protein MyD88

2

2

Small-scale

0.621

High

1189576

DTX1
E3 ubiquitin-protein ligase DTX1

1

1

Small-scale

0.618

High

1189583

CBLC
E3 ubiquitin-protein ligase CBL-C

1

5

Small-scale

0.618

High

868836

CRKL
Crk-like protein

2

20

Small-scale

0.588

High

767014

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

12

Small-scale

0.584

High

1189595

UBE2C
Ubiquitin-conjugating enzyme E2 C

1

12

Small-scale

0.579

High

1016752

H32
Histone H3.2

1

12

High-throughput

0.575

High

204543

SMAD7
Mothers against decapentaplegic homolog 7

1

4

Small-scale

0.561

High

1189581

TCAM1
TIR domain-containing adapter molecule 1

1

6

Small-scale

0.554

High

236827

LAT
Linker for activation of T-cells family member 1

2

2

High-throughput

0.552

High

1189573

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.552

High

440278

LCK
Proto-oncogene tyrosine-protein kinase LCK

1

20

Small-scale

0.501

High

561280

CD5
T-cell surface glycoprotein CD5

1

2

High-throughput

0.489

High

834251

CSK
Tyrosine-protein kinase CSK

1

20

High-throughput

0.484

High

711223

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

13

Small-scale

0.479

High

869540

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.479

High

1034935

KPCT
Protein kinase C theta type

1

6

Small-scale

0.479

High

1189577

SRBS1
Sorbin and SH3 domain-containing protein 1

1

20

Small-scale

0.479

High

1189578

CRK
Adapter molecule crk

1

20

Small-scale

0.479

High

1189586

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

2

Small-scale

0.479

High

1189589

EED
Polycomb protein EED

1

8

High-throughput

0.479

High

1189597

ARHG7
Rho guanine nucleotide exchange factor 7

1

20

Small-scale

0.479

High

1189588

S12A5
Solute carrier family 12 member 5

1

0

Small-scale

0.458

High

237074

NCK2
Cytoplasmic protein NCK2

1

20

High-throughput

0.445

High

313432

GRAP2
GRB2-related adaptor protein 2

1

20

High-throughput

0.445

High

625173

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

1

High-throughput

0.445

High

849097

ZAP70
Tyrosine-protein kinase ZAP-70

1

20

High-throughput

0.445

High

954339

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.445

High

961905

RL37A
Large ribosomal subunit protein eL43

1

2

High-throughput

0.445

High

969742

RS15A
Small ribosomal subunit protein uS8

1

2

High-throughput

0.445

High

972631

RS14
Small ribosomal subunit protein uS11

1

2

High-throughput

0.445

High

973666

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.445

High

984606

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.445

High

986951

PROF1
Profilin-1

1

5

High-throughput

0.445

High

989244

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.445

High

993480

RS17
Small ribosomal subunit protein eS17

1

1

High-throughput

0.445

High

993963

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.445

High

1189572

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

1

20

High-throughput

0.445

High

1189574

LCP2
Lymphocyte cytosolic protein 2

1

8

High-throughput

0.445

High

1189575

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

18

High-throughput

0.445

High

1189594

RS19
Small ribosomal subunit protein eS19

1

2

High-throughput

0.445

High

1189598

RL38
Large ribosomal subunit protein eL38

1

2

High-throughput

0.445

High

1189601

ITSN2
Intersectin-2

1

20

High-throughput

0.445

High

1189571

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

3

Small-scale

0.437

High

1189580

Q6P7T9
Nuclear factor of activated T-cells c1 isoform IA-IXS

1

10

Small-scale

0.437

High

570332

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.426

High

868921

RLA1
Large ribosomal subunit protein P1

1

0

High-throughput

0.426

High

974883

SMD3
Small nuclear ribonucleoprotein Sm D3

1

0

High-throughput

0.426

High

982051

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.426

High

995515

RL22
Large ribosomal subunit protein eL22

1

0

High-throughput

0.426

High

1189585

LAX1
Lymphocyte transmembrane adapter 1

1

0

High-throughput

0.426

High

801619

HSPA9
Stress-70 protein, mitochondrial

1

9

High-throughput

0.407

High

969107

PRS8
26S proteasome regulatory subunit 8

1

4

High-throughput

0.407

High

1189579

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

7

High-throughput

0.407

High

1189582

AN13A
Ankyrin repeat domain-containing protein 13A

1

8

High-throughput

0.407

High

1189584

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

20

High-throughput

0.407

High

1189587

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

3

High-throughput

0.407

High

1189591

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

4

High-throughput

0.407

High

1189592

GRAP
GRB2-related adapter protein

1

20

High-throughput

0.407

High

551426

A4
Amyloid-beta precursor protein

1

2

Small-scale

0.373

High

1189590

PSMD6
26S proteasome non-ATPase regulatory subunit 6

2

0

Small-scale

0.298

High

1189599

TLR4
Toll-like receptor 4

1

0

Small-scale

0.249

Low

1189593

GAPR1
Golgi-associated plant pathogenesis-related protein 1

1

0

High-throughput

0.232

Low

1189596

ATPD
ATP synthase F(1) complex subunit delta, mitochondrial

1

0

High-throughput

0.232

Low

1189600

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025