Interactor 1: DPH2 (O58832)
2-(3-amino-3-carboxypropyl)histidine synthase (EC 2.5.1.108) (Diphthamide biosynthesis protein Dph2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase)
Gene: DPH2

Interactor 2: DPH2 (O58832)
2-(3-amino-3-carboxypropyl)histidine synthase (EC 2.5.1.108) (Diphthamide biosynthesis protein Dph2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase)
Gene: DPH2

Species: Pyrococcus horikoshii OT3

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.41 1.00 0.647

The method score is based on:

Property Details
Experiments 29590073
Identification Methods x-ray crystallography
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Diphthamide_syn~Diphthamide_syn
Common GO terms GO:0016765 - transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0017183 - protein histidyl modification to diphthamide
GO:0046872 - metal ion binding
GO:0050843 - S-adenosylmethionine catabolic process
GO:0051539 - 4 iron, 4 sulfur cluster binding
and 1 others

more...

Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 342
Ph

1 342
+ Dm
+ Mm
+ Hs
+ Sp
+ Sc
+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024