HitPredict

Interactor 1: RAD21 (O60216)
Double-strand-break repair protein rad21 homolog (hHR21) (Nuclear matrix protein 1) (NXP-1) (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product) (65-kDa carboxy-terminal product)]
Gene: RAD21

Interactor 2: SMC1A (Q14683)
Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8)
Gene: SMC1A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.984

The method score is based on:

Property Details
Experiments 26496610, 31010829, 11590136, 31807710, 35271311, 23242214, 17112726, 28514442, 24981860, 33961781, 22145905, 21043528, 15737063, 22885700, 20818333
Identification Methods affinity chromatography technology, biochemical, two hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Rad21_Rec8~SMC_N, Rad21_Rec8_N~SMC_N
Common GO terms GO:0000775 - chromosome, centromeric region
GO:0000794 - condensed nuclear chromosome
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0005634 - nucleus
and 11 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 631
Hs

1 1233
+ Mm
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+ Xl
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+ Mm
+ Xl
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+ Dm
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+ Sc
+ Sp
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+ Sc

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Last updated: 15 Jul 2024