Protein: PLPP1
Phospholipid phosphatase 1 (EC 3.1.3.-) (EC 3.1.3.106) (EC 3.1.3.4) (EC 3.6.1.75) (Lipid phosphate phosphohydrolase 1) (PAP2-alpha) (Phosphatidate phosphohydrolase type 2a) (Phosphatidic acid phosphatase 2a) (PAP-2a) (PAP2a)

Gene: PLPP1
Organism: Homo sapiens
Interactions: 27
UniProt ID: O14494

Gene Ontology (top 5):
GO:0000810 - diacylglycerol diphosphate phosphatase activity
GO:0005886 - plasma membrane
GO:0005901 - caveola
GO:0006644 - phospholipid metabolic process
GO:0006670 - sphingosine metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

154519

PLPP2
Phospholipid phosphatase 2

2

11

Small-scale

0.789

High

154516

PLPP1
Phospholipid phosphatase 1

1

11

Small-scale

0.618

High

154517

PLPP3
Phospholipid phosphatase 3

1

11

Small-scale

0.618

High

154536

SSMM1
Serine-rich single-pass membrane protein 1

2

2

High-throughput

0.606

High

154520

CREB3
Cyclic AMP-responsive element-binding protein 3

2

2

High-throughput

0.590

High

154526

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

2

High-throughput

0.536

High

154518

GPR42
G-protein coupled receptor 42

1

2

High-throughput

0.515

High

154523

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.515

High

64925

ARRD5
Arrestin domain-containing protein 5

1

0

High-throughput

0.513

High

154524

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

0

High-throughput

0.493

High

154525

CASP1
Caspase-1

1

0

High-throughput

0.493

High

154527

KC1D
Casein kinase I isoform delta

1

0

High-throughput

0.493

High

154528

PSN1
Presenilin-1

1

0

High-throughput

0.493

High

154530

TGIF1
Homeobox protein TGIF1

1

0

High-throughput

0.493

High

154529

RAB2A
Ras-related protein Rab-2A

1

1

High-throughput

0.479

High

154540

LAMP3
Lysosome-associated membrane glycoprotein 3

1

3

High-throughput

0.479

High

154521

LAT3
Large neutral amino acids transporter small subunit 3

1

2

High-throughput

0.445

High

154522

NPT2B
Sodium-dependent phosphate transport protein 2B

1

2

High-throughput

0.445

High

154533

ZNT10
Calcium/manganese antiporter SLC30A10

1

2

High-throughput

0.445

High

154535

MOT10
Monocarboxylate transporter 10

1

4

High-throughput

0.445

High

154537

SO1B3
Solute carrier organic anion transporter family member 1B3

1

1

High-throughput

0.445

High

154538

FLVC2
Choline/ethanolamine transporter FLVCR2

1

2

High-throughput

0.445

High

154534

VGLU3
Vesicular glutamate transporter 3

1

0

High-throughput

0.426

High

154531

TRI68
E3 ubiquitin-protein ligase TRIM68

2

0

High-throughput

0.319

High

154539

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

0

High-throughput

0.268

Low

154532

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025