HitPredict

Interactor 1: MED14 (O60244)
Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150)
Gene: MED14

Interactor 2: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1454 Hs			1 377
+	Hs
		225333 MED14_HUMAN (1-1454): 0: 1560: 100.00		FYN_HUMAN (7-173): 7.47e-21: 96: 15.39
+	Hs
		225367 MED14_HUMAN (1-1454): 0: 1560: 100.00		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Rn
		192744 SYNJ1_RAT (909-1337): 2.07e-14: 81.1: 11.93		SRBS2_RAT (3-162): 4.86e-25: 109: 28.05
+	Hs
		195974 PLXB1_HUMAN (986-1225): 9.69e-23: 108: 18.39		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		442866 CBP_HUMAN (900-1355): 2.7e-13: 77.7: 10.70		HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24
+	Hs
		924632 TENS2_HUMAN (905-1243): 1.16e-17: 91.8: 14.14		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		782795 TENS2_HUMAN (905-1243): 1.16e-17: 91.8: 14.14		CSK_HUMAN (4-143): 1.92e-12: 70.2: 14.38
+	Hs
		523092 CBP_HUMAN (900-1355): 2.7e-13: 77.7: 10.70		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		522749 MUC1_HUMAN (958-1293): 3.26e-12: 73.7: 15.23		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		554292 MUC1_HUMAN (958-1293): 3.26e-12: 73.7: 15.23		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		624856 RPB1_HUMAN (1059-1159): 8.88e-09: 62.5: 23.30		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		924760 PRG4_HUMAN (985-1206): 9.56e-09: 62.5: 16.14		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Mm
		101430 F8VPR5_MOUSE (836-1217): 4.53e-09: 63.8: 7.75		CSK_MOUSE (4-143): 1.65e-12: 70.2: 14.38