HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: AL1A2 (O94788)
Retinal dehydrogenase 2 (RALDH 2) (RalDH2) (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (ALDH1A2) (Retinaldehyde-specific dehydrogenase type 2) (RALDH(II))
Gene: ALDH1A2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35987950
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010628 - positive regulation of gene expression GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 518
+	Hs
		226628 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AL1B1_HUMAN (1-518): 0: 681: 64.48
+	Hs
		226248 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ALDH2_HUMAN (6-518): 0: 663: 64.92
+	Hs
		226830 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AL9A1_HUMAN (41-518): 0: 550: 38.76
+	Hs
		228667 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AL8A1_HUMAN (41-513): 0: 526: 38.30
+	Hs
		475384 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AL1B1_HUMAN (1-518): 0: 681: 64.48
+	Sc
		477355 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		ALDH2_YEAST (36-517): 0: 568: 45.95
+	At
		1092390 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		AL2B4_ARATH (21-515): 0: 637: 56.36
+	At
		1091706 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		AL2C4_ARATH (33-513): 0: 593: 51.04
+	Hs
		475850 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AL1L2_HUMAN (37-513): 0: 571: 49.28