HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PDIA4 (P13667)
Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72)
Gene: PDIA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 24244333
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0034976 - response to endoplasmic reticulum stress
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 645
+	Hs
		227992 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47
+	Hs
		226279 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PDIA1_HUMAN (4-165): 4.25e-32: 132: 27.11
+	Hs
		227501 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PDIA6_HUMAN (57-283): 2.92e-31: 128: 28.51
+	Hs
		226618 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PDIA3_HUMAN (7-188): 4.76e-28: 120: 28.35
+	Hs
		228073 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TXND5_HUMAN (547-631): 1.03e-21: 100: 34.48
+	Hs
		312626 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47
+	At
		1092003 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PDI14_ARATH (38-546): 4.17e-47: 177: 18.17