Protein: C5AR1
C5a anaphylatoxin chemotactic receptor 1 (C5a anaphylatoxin chemotactic receptor) (C5a-R) (C5aR) (CD antigen CD88)

Gene: C5AR1
Organism: Homo sapiens
Interactions: 151
UniProt ID: P21730

Gene Ontology (top 5):
GO:0001774 - microglial cell activation
GO:0002430 - complement receptor mediated signaling pathway
GO:0004878 - complement component C5a receptor activity
GO:0004930 - G protein-coupled receptor activity
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

640386

MTR1L
Melatonin-related receptor

1

17

High-throughput

0.691

High

369967

CO5
Complement C5

1

8

Small-scale

0.647

High

640367

ARRB2
Beta-arrestin-2

1

13

Small-scale

0.618

High

640375

ARRB1
Beta-arrestin-1

1

13

Small-scale

0.618

High

640467

GOLP3
Golgi phosphoprotein 3

2

6

High-throughput

0.601

High

418592

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

15

Small-scale

0.575

High

475892

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

16

Small-scale

0.575

High

640370

WASP
Actin nucleation-promoting factor WAS

1

3

Small-scale

0.573

High

610985

PTN1
Tyrosine-protein phosphatase non-receptor type 1

2

16

High-throughput

0.549

High

640393

RABL3
Rab-like protein 3

2

6

High-throughput

0.549

High

65333

TCAF2
TRPM8 channel-associated factor 2

1

3

High-throughput

0.536

High

178183

NPC1
NPC intracellular cholesterol transporter 1

1

4

High-throughput

0.536

High

184117

RER1
Protein RER1

1

3

High-throughput

0.536

High

252657

TSN3
Tetraspanin-3

1

16

High-throughput

0.536

High

255977

S19A2
Thiamine transporter 1

1

9

High-throughput

0.536

High

297145

PRAF3
PRA1 family protein 3

1

5

High-throughput

0.536

High

565555

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

20

High-throughput

0.536

High

640366

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

20

High-throughput

0.536

High

640368

ATP7B
Copper-transporting ATPase 2

1

20

High-throughput

0.536

High

640372

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

3

High-throughput

0.536

High

640374

AGRE5
Adhesion G protein-coupled receptor E5

1

11

High-throughput

0.536

High

640376

CAV2
Caveolin-2

1

4

High-throughput

0.536

High

640377

CTR2
Cationic amino acid transporter 2

1

14

High-throughput

0.536

High

640379

AT12A
Potassium-transporting ATPase alpha chain 2

1

20

High-throughput

0.536

High

640380

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

20

High-throughput

0.536

High

640383

CLN3
Battenin

1

1

High-throughput

0.536

High

640384

ATM
Serine-protein kinase ATM

1

18

High-throughput

0.536

High

640385

PKD2
Polycystin-2

1

1

High-throughput

0.536

High

640387

ITPR2
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2

1

2

High-throughput

0.536

High

640388

AT2B3
Plasma membrane calcium-transporting ATPase 3

1

20

High-throughput

0.536

High

640389

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

12

High-throughput

0.536

High

640396

TM63B
Mechanosensitive cation channel TMEM63B

1

5

High-throughput

0.536

High

640398

AB17B
Alpha/beta hydrolase domain-containing protein 17B

1

11

High-throughput

0.536

High

640400

LMBD2
G-protein coupled receptor-associated protein LMBRD2

1

10

High-throughput

0.536

High

640403

S39A4
Zinc transporter ZIP4

1

12

High-throughput

0.536

High

640406

AN13D
Ankyrin repeat domain-containing protein 13D

1

6

High-throughput

0.536

High

640422

T161B
Transmembrane protein 161B

1

8

High-throughput

0.536

High

640424

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

7

High-throughput

0.536

High

640426

S35G2
Solute carrier family 35 member G2

1

8

High-throughput

0.536

High

640428

CIP2A
Protein CIP2A

1

5

High-throughput

0.536

High

640429

SPPL3
Signal peptide peptidase-like 3

1

5

High-throughput

0.536

High

640434

LMBR1
Limb region 1 protein homolog

1

3

High-throughput

0.536

High

640436

CTR3
Cationic amino acid transporter 3

1

14

High-throughput

0.536

High

640438

YLAT2
Y+L amino acid transporter 2

1

15

High-throughput

0.536

High

640440

CDS1
Phosphatidate cytidylyltransferase 1

1

2

High-throughput

0.536

High

640451

RADIL
Ras-associating and dilute domain-containing protein

1

16

High-throughput

0.536

High

640453

XPO6
Exportin-6

1

4

High-throughput

0.536

High

640456

TTYH2
Protein tweety homolog 2

1

5

High-throughput

0.536

High

640461

YIPF3
Protein YIPF3

1

9

High-throughput

0.536

High

640468

XKR8
XK-related protein 8

1

1

High-throughput

0.536

High

640473

GPC5C
G-protein coupled receptor family C group 5 member C

1

6

High-throughput

0.536

High

640474

SERC1
Serine incorporator 1

1

4

High-throughput

0.536

High

640479

S39A1
Zinc transporter ZIP1

1

12

High-throughput

0.536

High

640482

S39AA
Zinc transporter ZIP10

1

12

High-throughput

0.536

High

640486

AGRG1
Adhesion G-protein coupled receptor G1

1

11

High-throughput

0.536

High

403125

APOB
Apolipoprotein B-100

1

0

High-throughput

0.513

High

615476

NELFE
Negative elongation factor E

1

0

High-throughput

0.513

High

640382

NTCP7
Sodium/bile acid cotransporter 7

1

0

High-throughput

0.513

High

640435

CANT1
Soluble calcium-activated nucleotidase 1

1

0

High-throughput

0.513

High

47904

S12A8
Solute carrier family 12 member 8

1

20

High-throughput

0.489

High

165530

SCAM3
Secretory carrier-associated membrane protein 3

1

6

High-throughput

0.489

High

173655

BTAF1
TATA-binding protein-associated factor 172

1

10

High-throughput

0.489

High

178902

SCAM2
Secretory carrier-associated membrane protein 2

1

6

High-throughput

0.489

High

186403

TM9S1
Transmembrane 9 superfamily member 1

1

7

High-throughput

0.489

High

226399

SNG2
Synaptogyrin-2

1

5

High-throughput

0.489

High

273161

CAND2
Cullin-associated NEDD8-dissociated protein 2

1

11

High-throughput

0.489

High

295905

SC5D
Lathosterol oxidase

1

10

High-throughput

0.489

High

318112

IPO13
Importin-13

1

16

High-throughput

0.489

High

350524

CF047
Uncharacterized protein C6orf47

1

2

High-throughput

0.489

High

360249

COX1
Cytochrome c oxidase subunit 1

1

2

High-throughput

0.489

High

536233

PPAL
Lysosomal acid phosphatase

1

2

High-throughput

0.489

High

640369

FDFT
Squalene synthase

1

1

High-throughput

0.489

High

640373

PTSS1
Phosphatidylserine synthase 1

1

8

High-throughput

0.489

High

640381

KDSR
3-ketodihydrosphingosine reductase

1

5

High-throughput

0.489

High

640391

MBRL
Membralin

1

3

High-throughput

0.489

High

640392

AG10A
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

1

6

High-throughput

0.489

High

640394

TT39A
Tetratricopeptide repeat protein 39A

1

1

High-throughput

0.489

High

640395

S35F1
Solute carrier family 35 member F1

1

7

High-throughput

0.489

High

640397

TM164
Transmembrane protein 164

1

2

High-throughput

0.489

High

640399

RN213
E3 ubiquitin-protein ligase RNF213

1

1

High-throughput

0.489

High

640401

RINT1
RAD50-interacting protein 1

1

5

High-throughput

0.489

High

640402

ZNT6
Zinc transporter 6

1

7

High-throughput

0.489

High

640404

PAQR3
Progestin and adipoQ receptor family member 3

1

2

High-throughput

0.489

High

640405

THADA
tRNA

1

4

High-throughput

0.489

High

640407

DPH6
Diphthine--ammonia ligase

1

3

High-throughput

0.489

High

640408

DYM
Dymeclin

1

6

High-throughput

0.489

High

640411

RETR3
Reticulophagy regulator 3

1

5

High-throughput

0.489

High

640412

DAAF5
Dynein axonemal assembly factor 5

1

6

High-throughput

0.489

High

640413

S35F2
Solute carrier family 35 member F2

1

7

High-throughput

0.489

High

640414

K2013
Uncharacterized protein KIAA2013

1

4

High-throughput

0.489

High

640415

CKLF4
CKLF-like MARVEL transmembrane domain-containing protein 4

1

6

High-throughput

0.489

High

640416

VKORL
Vitamin K epoxide reductase complex subunit 1-like protein 1

1

5

High-throughput

0.489

High

640417

VPS8
Vacuolar protein sorting-associated protein 8 homolog

1

1

High-throughput

0.489

High

640418

STAG2
Cohesin subunit SA-2

1

2

High-throughput

0.489

High

640419

FITM2
Acyl-coenzyme A diphosphatase FITM2

1

4

High-throughput

0.489

High

640420

ARL10
ADP-ribosylation factor-like protein 10

1

10

High-throughput

0.489

High

640421

S38A9
Neutral amino acid transporter 9

1

1

High-throughput

0.489

High

640423

MFSD8
Major facilitator superfamily domain-containing protein 8

1

11

High-throughput

0.489

High

640425

GOGA5
Golgin subfamily A member 5

1

5

High-throughput

0.489

High

640427

TBC15
TBC1 domain family member 15

1

6

High-throughput

0.489

High

640430

PIGO
GPI ethanolamine phosphate transferase 3, catalytic subunit

1

12

High-throughput

0.489

High

640431

CHPT1
Cholinephosphotransferase 1

1

5

High-throughput

0.489

High

640432

S35F5
Solute carrier family 35 member F5

1

7

High-throughput

0.489

High

640433

STAG1
Cohesin subunit SA-1

1

2

High-throughput

0.489

High

640437

BRI3B
BRI3-binding protein

1

1

High-throughput

0.489

High

640439

ALG3
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

1

1

High-throughput

0.489

High

640441

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

20

High-throughput

0.489

High

640442

RFT1
Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1

1

1

High-throughput

0.489

High

640443

S2546
Mitochondrial outer membrane protein SLC25A46

1

4

High-throughput

0.489

High

640444

EVI5L
EVI5-like protein

1

3

High-throughput

0.489

High

640445

F241B
Protein FAM241B

1

4

High-throughput

0.489

High

640446

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

1

High-throughput

0.489

High

640448

TV23C
Golgi apparatus membrane protein TVP23 homolog C

1

4

High-throughput

0.489

High

640449

CERS2
Ceramide synthase 2

1

19

High-throughput

0.489

High

640450

RN185
E3 ubiquitin-protein ligase RNF185

1

8

High-throughput

0.489

High

640452

MBOA7
Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7

1

8

High-throughput

0.489

High

640454

SGMR1
Sigma non-opioid intracellular receptor 1

1

6

High-throughput

0.489

High

640455

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

3

High-throughput

0.489

High

640457

GCP2
Gamma-tubulin complex component 2

1

14

High-throughput

0.489

High

640458

FACD2
Fanconi anemia group D2 protein

1

6

High-throughput

0.489

High

640459

FUT8
Alpha-(1,6)-fucosyltransferase

1

1

High-throughput

0.489

High

640460

XPO4
Exportin-4

1

16

High-throughput

0.489

High

640462

UN93B
Protein unc-93 homolog B1

1

4

High-throughput

0.489

High

640463

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

3

High-throughput

0.489

High

640464

TM245
Transmembrane protein 245

1

1

High-throughput

0.489

High

640466

GLP3L
Golgi phosphoprotein 3-like

1

6

High-throughput

0.489

High

640469

REEP4
Receptor expression-enhancing protein 4

1

7

High-throughput

0.489

High

640470

AT133
Polyamine-transporting ATPase 13A3

1

20

High-throughput

0.489

High

640471

CERS4
Ceramide synthase 4

1

19

High-throughput

0.489

High

640472

RRAGC
Ras-related GTP-binding protein C

1

4

High-throughput

0.489

High

640475

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

1

4

High-throughput

0.489

High

640476

RMND1
Required for meiotic nuclear division protein 1 homolog

1

3

High-throughput

0.489

High

640477

T161A
Transmembrane protein 161A

1

8

High-throughput

0.489

High

640478

ELOV2
Very long chain fatty acid elongase 2

1

8

High-throughput

0.489

High

640480

B4GT7
Beta-1,4-galactosyltransferase 7

1

1

High-throughput

0.489

High

640483

TPC1
Two pore channel protein 1

1

2

High-throughput

0.489

High

640484

CIA30
Complex I intermediate-associated protein 30, mitochondrial

1

1

High-throughput

0.489

High

640485

TNPO3
Transportin-3

1

14

High-throughput

0.489

High

640378

SC5A3
Sodium/myo-inositol cotransporter

1

4

High-throughput

0.445

High

506551

GPHRB
Golgi pH regulator B

1

18

High-throughput

0.437

High

85334

GPHRA
Golgi pH regulator A

1

18

High-throughput

0.407

High

179820

BET1
BET1 homolog

1

0

High-throughput

0.279

Low

301338

WFS1
Wolframin

1

0

High-throughput

0.279

Low

322003

ENDD1
Endonuclease domain-containing 1 protein

1

0

High-throughput

0.279

Low

640371

MSS4
Guanine nucleotide exchange factor MSS4

1

0

High-throughput

0.279

Low

640390

GNPTA
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta

1

0

High-throughput

0.279

Low

640409

SETX
Probable helicase senataxin

1

0

High-throughput

0.279

Low

640410

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

640447

SAAL1
Protein SAAL1

1

0

High-throughput

0.279

Low

640465

PIGM
GPI alpha-1,4-mannosyltransferase I, catalytic subunit

1

0

High-throughput

0.279

Low

640481

GNPTG
N-acetylglucosamine-1-phosphotransferase subunit gamma

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025