HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PSB6 (P28072)
Proteasome subunit beta type-6 (EC 3.4.25.1) (Macropain delta chain) (Multicatalytic endopeptidase complex delta chain) (Proteasome delta chain) (Proteasome subunit Y)
Gene: PSMB6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 23503661
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 239
+	Hs
		228452 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSB7_HUMAN (28-229): 2.05e-84: 254: 30.69
+	Hs
		226590 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSA5_HUMAN (3-230): 3.68e-84: 252: 18.75
+	Hs
		226567 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSA4_HUMAN (6-232): 2.37e-82: 248: 15.19
+	Hs
		156176 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSA7_HUMAN (8-231): 4.14e-80: 242: 18.03
+	Hs
		226730 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSB10_HUMAN (28-236): 9.34e-80: 242: 27.62
+	Hs
		226593 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSB5_HUMAN (13-235): 4.14e-75: 230: 30.36
+	Sc
		477138 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		PSA3_YEAST (5-235): 1.1e-79: 241: 16.94
+	Hs
		474931 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		PSA4_HUMAN (6-232): 2.37e-82: 248: 15.19
+	Zm
		35351 Q42415_MAIZE (1-153): 8.84e-50: 179: 20.13		A0A1D6LKR2_MAIZE (11-232): 5.1e-83: 249: 47.79
+	At
		286456 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSA4A_ARATH (6-235): 2.27e-87: 260: 17.08
+	Hs
		476251 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSB7_HUMAN (28-229): 2.05e-84: 254: 30.69
+	Hs
		475369 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSA5_HUMAN (3-230): 3.68e-84: 252: 18.75
+	At
		188702 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSB7A_ARATH (31-235): 1.06e-82: 249: 30.73
+	Hs
		156205 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSA7_HUMAN (8-231): 4.14e-80: 242: 18.03
+	Hs
		475370 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSB6_HUMAN (1-239): 1.24e-79: 240: 100.00
+	At
		189234 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSA7B_ARATH (8-229): 4.66e-79: 239: 18.70
+	At
		188696 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSA2A_ARATH (8-232): 9.94e-79: 238: 16.81
+	At
		286449 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSA6A_ARATH (8-234): 3.01e-78: 237: 16.88
+	At
		188713 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSB5A_ARATH (20-239): 1.66e-76: 233: 30.49
+	Hs
		475371 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSB5_HUMAN (13-235): 4.14e-75: 230: 30.36