Protein: PYGO2
Pygopus homolog 2

Gene: PYGO2
Organism: Homo sapiens
Interactions: 52
UniProt ID: Q9BRQ0

Gene Ontology (top 5):
GO:0001822 - kidney development
GO:0002088 - lens development in camera-type eye
GO:0003682 - chromatin binding
GO:0005654 - nucleoplasm
GO:0007289 - spermatid nucleus differentiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

139021

BCL9
B-cell CLL/lymphoma 9 protein

4

4

Small-scale

0.691

High

161507

KMT2D
Histone-lysine N-methyltransferase 2D

1

0

Small-scale

0.687

High

1368469

CBP
CREB-binding protein

1

0

Small-scale

0.687

High

1369156

KAT2A
Histone acetyltransferase KAT2A

1

0

Small-scale

0.687

High

1289053

BCL9L
B-cell CLL/lymphoma 9-like protein

2

3

High-throughput

0.628

High

1411574

PYGO2
Pygopus homolog 2

1

0

Small-scale

0.586

High

1145516

RBBP5
Retinoblastoma-binding protein 5

1

1

Small-scale

0.561

High

728407

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

Small-scale

0.537

High

965197

WDR5
WD repeat-containing protein 5

1

0

Small-scale

0.537

High

1157892

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.537

High

1411575

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

0

Small-scale

0.537

High

1411581

DCAF1
DDB1- and CUL4-associated factor 1

1

1

Small-scale

0.501

High

283621

SUPT3
Transcription initiation protein SPT3 homolog

1

0

Small-scale

0.480

High

1411580

TRRAP
Transformation/transcription domain-associated protein

1

0

Small-scale

0.480

High

143222

NFIB
Nuclear factor 1 B-type

1

3

High-throughput

0.479

High

210106

CRX
Cone-rod homeobox protein

1

6

High-throughput

0.479

High

225094

TLX3
T-cell leukemia homeobox protein 3

1

4

High-throughput

0.479

High

474246

NFIC
Nuclear factor 1 C-type

1

3

High-throughput

0.479

High

540938

ERG
Transcriptional regulator ERG

1

1

High-throughput

0.479

High

765000

CTNB1
Catenin beta-1

1

2

Small-scale

0.479

High

776237

SOX6
Transcription factor SOX-6

1

3

High-throughput

0.479

High

846931

ETV4
ETS translocation variant 4

1

1

High-throughput

0.479

High

872689

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

877553

LHX1
LIM/homeobox protein Lhx1

1

10

High-throughput

0.479

High

938498

PAX9
Paired box protein Pax-9

1

2

High-throughput

0.479

High

1048079

TLE3
Transducin-like enhancer protein 3

1

1

High-throughput

0.479

High

1056641

PAX8
Paired box protein Pax-8

1

2

High-throughput

0.479

High

1087979

NFIA
Nuclear factor 1 A-type

1

3

High-throughput

0.479

High

1351142

SP7
Transcription factor Sp7

1

2

High-throughput

0.479

High

1379940

LHX4
LIM/homeobox protein Lhx4

1

11

High-throughput

0.479

High

1411577

LHX3
LIM/homeobox protein Lhx3

1

11

High-throughput

0.479

High

520333

ANDR
Androgen receptor

1

0

High-throughput

0.458

High

538462

EGR2
E3 SUMO-protein ligase EGR2

1

0

High-throughput

0.458

High

1045707

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1115033

CUL4A
Cullin-4A

1

0

Small-scale

0.458

High

1145836

IRF4
Interferon regulatory factor 4

1

0

High-throughput

0.458

High

1160887

TBR1
T-box brain protein 1

1

0

High-throughput

0.458

High

1339153

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1411578

KLF15
Krueppel-like factor 15

1

0

High-throughput

0.458

High

226592

TLX2
T-cell leukemia homeobox protein 2

1

3

High-throughput

0.437

High

286822

JERKY
Jerky protein homolog

1

1

Small-scale

0.437

High

662270

PAX7
Paired box protein Pax-7

1

3

High-throughput

0.437

High

725311

TLX1
T-cell leukemia homeobox protein 1

1

3

High-throughput

0.437

High

776118

SOX5
Transcription factor SOX-5

1

2

High-throughput

0.437

High

1133631

NFIX
Nuclear factor 1 X-type

1

3

High-throughput

0.437

High

1229369

LHX8
LIM/homeobox protein Lhx8

1

11

High-throughput

0.437

High

1240685

CDC73
Parafibromin

1

0

Small-scale

0.426

High

949199

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.279

Low

1411576

GRHPR
Glyoxylate reductase/hydroxypyruvate reductase

1

0

High-throughput

0.279

Low

1411579

SORC3
VPS10 domain-containing receptor SorCS3

1

0

High-throughput

0.268

Low

767319

MERL
Merlin

1

0

Small-scale

0.261

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025