HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: WEE1 (P30291)
Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase)
Gene: WEE1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 646
+	Hs
		226638 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKT2_HUMAN (188-643): 1.6e-125: 381: 18.01
+	Hs
		226637 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKT1_HUMAN (181-634): 2.52e-123: 376: 16.17
+	Hs
		227381 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KCC2D_HUMAN (293-630): 2.17e-106: 332: 21.25
+	Hs
		229082 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KCC2A_HUMAN (293-630): 4.62e-102: 320: 21.47
+	Hs
		682055 RNF14_HUMAN (161-464): 6.69e-69: 229: 21.56		AKT1_HUMAN (181-634): 2.52e-123: 376: 16.17
+	Hs
		474936 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AKT2_HUMAN (188-643): 1.6e-125: 381: 18.01
+	Hs
		474935 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AKT1_HUMAN (181-634): 2.52e-123: 376: 16.17
+	At
		1091642 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CDPKB_ARATH (274-641): 6.19e-127: 385: 20.05
+	At
		1091641 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		KIN10_ARATH (298-642): 1.19e-125: 382: 19.32
+	Hs
		475390 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AKT1_HUMAN (181-634): 2.52e-123: 376: 16.17
+	At
		1091676 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CDPK3_ARATH (299-641): 1.87e-123: 377: 20.33
+	Hs
		228945 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		STK26_HUMAN (299-577): 3.87e-19: 92: 28.18
+	Hs
		227317 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		STK4_HUMAN (286-572): 1.36e-17: 88.2: 26.89
+	At
		955189 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		KIN11_ARATH (298-642): 1.9e-120: 369: 19.32
+	Hs
		228149 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NEK7_HUMAN (303-558): 5.18e-18: 87: 25.55
+	Hs
		475723 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		KCC2D_HUMAN (293-630): 2.17e-106: 332: 21.25
+	Hs
		475012 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		STK4_HUMAN (286-572): 1.36e-17: 88.2: 26.89
+	Sp
		477564 UBI4P_SCHPO (1-76): 1.1e-29: 121: 31.58		MIK1_SCHPO (165-576): 4.92e-22: 102: 24.89