HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: VDAC2 (P45880)
Voltage-dependent anion-selective channel protein 2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2)
Gene: VDAC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.739

Property	Details
Experiments	32929329, 35509820, 35256949, 23068103, 23060438, 23503661, 32814053
Identification Methods	affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 294
+	Hs
		226516 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		VDAC1_HUMAN (12-294): 1.42e-110: 323: 74.56
+	Hs
		229093 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		VDAC3_HUMAN (12-294): 1.21e-108: 318: 73.50
+	Hs
		226184 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TOM40_HUMAN (12-290): 1.58e-72: 228: 12.63
+	Hs
		475333 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		VDAC1_HUMAN (12-294): 1.42e-110: 323: 74.56
+	Hs
		476591 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		VDAC3_HUMAN (12-294): 1.21e-108: 318: 73.50
+	At
		1092039 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		VDAC2_ARATH (13-293): 1.24e-75: 234: 19.72