HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: TCPE (P48643)
T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon) (Chaperonin containing T-complex polypeptide 1 subunit 5)
Gene: CCT5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	25959826, 32929329, 35509820, 35256949
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0050821 - protein stabilization
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 541
+	Hs
		226839 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TCPG_HUMAN (14-540): 0: 572: 33.15
+	Hs
		228487 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TCPH_HUMAN (12-539): 0: 570: 29.64
+	Hs
		226467 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TCPA_HUMAN (26-541): 0: 545: 32.08
+	Hs
		475476 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TCPE_HUMAN (1-541): 0: 635: 100.00
+	Hs
		226892 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TCPD_HUMAN (36-533): 1.62e-107: 333: 39.80
+	At
		138353 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		TCPE_ARATH (6-538): 0: 606: 68.29
+	Hs
		475479 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TCPG_HUMAN (14-540): 0: 572: 33.15
+	Hs
		476269 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TCPH_HUMAN (12-539): 0: 570: 29.64
+	Hs
		475319 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TCPA_HUMAN (26-541): 0: 545: 32.08
+	Hs
		475496 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TCPD_HUMAN (36-533): 1.62e-107: 333: 39.80
+	At
		1092187 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		TCPD_ARATH (36-533): 1.54e-103: 323: 40.04