HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.941

Property	Details
Experiments	32929329, 35509820, 35256949, 12676955, 20810900, 23503661
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	AAA~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:1901800 - positive regulation of proteasomal protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 406
+	Hs
		227060 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		226773 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Hs
		226693 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31
+	Ce
		183868 Q9XUS3_CAEEL (6-464): 2.19e-70: 230: 25.44		PRS4_CAEEL (73-396): 1.16e-109: 330: 50.31
+	Hs
		474950 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Sc
		477201 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		PRS7_YEAST (84-391): 1.53e-111: 336: 54.87
+	At
		1092308 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PRS6B_ARATH (2-403): 2.14e-137: 400: 40.05
+	Hs
		475570 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		475569 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		475459 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	At
		1092307 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PS10A_ARATH (16-403): 1.49e-121: 359: 43.22
+	Hs
		475422 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31
+	Hs
		227077 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64
+	At
		1092219 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CD48E_ARATH (135-382): 2.65e-82: 270: 40.32
+	At
		1092294 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CD48D_ARATH (135-382): 5.13e-82: 269: 39.11
+	Sc
		477414 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		PRS8_YEAST (8-110): 1.31e-09: 61.7: 7.77
+	At
		1092257 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PS10B_ARATH (8-125): 2.97e-11: 66.7: 6.78
+	Hs
		475580 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64
+	At
		1091926 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PRS8B_ARATH (9-123): 1.82e-10: 64.4: 6.96
+	At
		1091962 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PRS8A_ARATH (9-123): 1.96e-10: 64: 6.96