HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	32929329, 35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032092 - positive regulation of protein binding
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 216
+	Hs
		227513 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RAB35_HUMAN (6-188): 1.31e-87: 258: 29.19
+	Hs
		228651 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RAB1B_HUMAN (4-195): 1.12e-80: 240: 28.72
+	Hs
		227028 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RAB10_HUMAN (11-177): 3.9e-29: 109: 33.14
+	Hs
		226899 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RAB7A_HUMAN (8-166): 7.44e-29: 108: 33.13
+	Hs
		918975 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		RAB1A_HUMAN (1-196): 3.67e-82: 244: 28.00
+	Sc
		350834 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		YPT1_YEAST (4-187): 6.68e-83: 247: 26.74
+	At
		784986 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		RAN1_ARATH (1-216): 1.39e-95: 279: 73.52
+	At
		784997 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		RAN2_ARATH (1-215): 1.36e-88: 261: 74.77
+	At
		1091766 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		RAN3_ARATH (1-215): 9.1e-84: 249: 74.31
+	At
		656930 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		RAD2A_ARATH (4-209): 4.44e-81: 242: 26.79
+	Zm
		24708 A0A1D6IJX7_MAIZE (233-459): 1.19e-26: 116: 21.70		B4FNJ6_MAIZE (6-206): 3.7e-78: 235: 25.37
+	Hs
		475035 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		RAB30_HUMAN (11-171): 6.76e-30: 111: 35.37
+	Hs
		475812 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RAB30_HUMAN (11-171): 6.76e-30: 111: 35.37