HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PI42B (P78356)
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta)
Gene: PIP4K2B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0010506 - regulation of autophagy
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 416
+	Hs
		228128 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PI42C_HUMAN (2-415): 4.34e-169: 481: 64.05
+	Hs
		226812 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PI42A_HUMAN (14-416): 5.22e-164: 468: 77.92
+	Hs
		228480 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PI51A_HUMAN (10-415): 1.41e-159: 463: 30.64
+	Hs
		1306336 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		PI51A_HUMAN (10-415): 1.41e-159: 463: 30.64
+	Hs
		231370 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PI51C_HUMAN (2-415): 1.52e-159: 466: 28.23
+	At
		1092313 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PI5K6_ARATH (3-415): 8.11e-147: 435: 25.46
+	At
		1091827 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PI5K8_ARATH (42-415): 7.18e-131: 396: 28.87