Protein: SYNC
Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS) (Asparaginyl-tRNA synthetase 1)

Gene: SYNC, NARS1
Organism: Homo sapiens
Interactions: 117
UniProt ID: O43776

Gene Ontology (top 5):
GO:0003676 - nucleic acid binding
GO:0004816 - asparagine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

227144

KLH20
Kelch-like protein 20

3

1

High-throughput

0.667

High

227115

PXL2B
Prostamide/prostaglandin F synthase

3

0

High-throughput

0.638

High

227116

DUS19
Dual specificity protein phosphatase 19

3

0

High-throughput

0.638

High

227045

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

1

High-throughput

0.628

High

227059

3BHS2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

2

1

High-throughput

0.628

High

227125

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

2

2

High-throughput

0.628

High

227127

CDK15
Cyclin-dependent kinase 15

2

2

High-throughput

0.628

High

227072

ATX1
Ataxin-1

2

2

High-throughput

0.620

High

227037

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

14

High-throughput

0.618

High

227062

T2EB
Transcription initiation factor IIE subunit beta

2

0

High-throughput

0.602

High

227104

TRM11
tRNA

2

0

High-throughput

0.602

High

227117

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

0

High-throughput

0.602

High

227141

DD19B
ATP-dependent RNA helicase DDX19B

2

0

High-throughput

0.585

High

227038

PRKN
E3 ubiquitin-protein ligase parkin

2

9

High-throughput

0.584

High

227047

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

4

High-throughput

0.584

High

227074

DSRAD
Double-stranded RNA-specific adenosine deaminase

2

2

High-throughput

0.584

High

227098

A16L1
Autophagy-related protein 16-1

2

8

High-throughput

0.571

High

227094

NEXMI
Neurite extension and migration factor

2

0

High-throughput

0.559

High

227061

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.553

High

227063

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.553

High

227052

TAU
Microtubule-associated protein tau

2

1

High-throughput

0.552

High

227040

DNJB6
DnaJ homolog subfamily B member 6

1

2

High-throughput

0.536

High

227046

FINC
Fibronectin

1

2

High-throughput

0.536

High

227055

AATC
Aspartate aminotransferase, cytoplasmic

1

1

High-throughput

0.536

High

227057

RL35A
Large ribosomal subunit protein eL33

1

1

High-throughput

0.536

High

227093

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.536

High

227103

HAKAI
E3 ubiquitin-protein ligase Hakai

1

3

Small-scale

0.536

High

227107

DDX60
Probable ATP-dependent RNA helicase DDX60

1

2

High-throughput

0.536

High

227119

HDAC2
Histone deacetylase 2

1

2

High-throughput

0.536

High

227123

OPTN
Optineurin

1

3

High-throughput

0.536

High

227049

JUN
Transcription factor Jun

2

4

High-throughput

0.521

High

227083

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.513

High

227106

CBCO1
Ciliary-associated calcium-binding coiled-coil protein 1

1

0

High-throughput

0.513

High

227120

BAD
Bcl2-associated agonist of cell death

1

0

High-throughput

0.513

High

227129

SRRT
Serrate RNA effector molecule homolog

1

0

High-throughput

0.513

High

227136

CENPM
Centromere protein M

1

0

High-throughput

0.513

High

177978

LSM1
U6 snRNA-associated Sm-like protein LSm1

1

4

High-throughput

0.508

High

227077

S10AA
Protein S100-A10

1

0

High-throughput

0.493

High

227128

CPPED
Serine/threonine-protein phosphatase CPPED1

1

0

High-throughput

0.493

High

227066

MAGA9
Melanoma-associated antigen 9

1

1

High-throughput

0.489

High

227090

CD226
CD226 antigen

1

4

High-throughput

0.489

High

227108

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

3

High-throughput

0.489

High

227124

RMC1
Regulator of MON1-CCZ1 complex

1

1

High-throughput

0.489

High

227143

NTNG1
Netrin-G1

1

1

High-throughput

0.489

High

227092

HSPB2
Heat shock protein beta-2

1

0

High-throughput

0.486

High

156730

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.479

High

227044

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

227048

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

227050

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

227051

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

6

High-throughput

0.479

High

227053

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

1

High-throughput

0.479

High

227065

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

227069

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

2

High-throughput

0.479

High

227071

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.479

High

227073

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

6

High-throughput

0.479

High

227075

HDAC4
Histone deacetylase 4

1

4

High-throughput

0.479

High

227081

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

227086

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

2

High-throughput

0.479

High

227088

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

2

High-throughput

0.479

High

227089

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

227096

CE170
Centrosomal protein of 170 kDa

1

3

High-throughput

0.479

High

227097

RN123
E3 ubiquitin-protein ligase RNF123

1

2

High-throughput

0.479

High

227099

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

227101

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

227109

RHG24
Rho GTPase-activating protein 24

1

2

High-throughput

0.479

High

227118

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

227121

ARHG2
Rho guanine nucleotide exchange factor 2

1

1

High-throughput

0.479

High

227126

SCLT1
Sodium channel and clathrin linker 1

1

4

High-throughput

0.479

High

227130

ATG5
Autophagy protein 5

1

1

High-throughput

0.479

High

227131

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.479

High

227133

ANLN
Anillin

1

2

High-throughput

0.479

High

227135

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

227139

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

123515

MYO1C
Unconventional myosin-Ic

1

0

High-throughput

0.458

High

184251

NPHP1
Nephrocystin-1

1

0

High-throughput

0.458

High

227056

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

227064

SPB5
Serpin B5

1

0

High-throughput

0.458

High

227067

RL21
Large ribosomal subunit protein eL21

1

0

High-throughput

0.458

High

227078

MGN
Protein mago nashi homolog

1

0

High-throughput

0.458

High

227082

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

227122

FERM2
Fermitin family homolog 2

1

0

High-throughput

0.458

High

227079

SUMO2
Small ubiquitin-related modifier 2

1

4

High-throughput

0.457

High

142243

PEX7
Peroxisomal targeting signal 2 receptor

1

7

High-throughput

0.445

High

227095

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

227134

ITM2C
Integral membrane protein 2C

1

2

High-throughput

0.445

High

227137

DDX28
Probable ATP-dependent RNA helicase DDX28

1

1

High-throughput

0.445

High

227142

GAB2
GRB2-associated-binding protein 2

1

3

High-throughput

0.445

High

104906

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

227039

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.437

High

227041

RHBT1
Rho-related BTB domain-containing protein 1

1

4

High-throughput

0.437

High

227054

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

227058

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.437

High

227068

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.437

High

227080

WDR5
WD repeat-containing protein 5

1

5

High-throughput

0.437

High

227084

TIF1B
Transcription intermediary factor 1-beta

1

5

High-throughput

0.437

High

227091

EZH2
Histone-lysine N-methyltransferase EZH2

1

4

High-throughput

0.437

High

227102

CE128
Centrosomal protein of 128 kDa

1

2

High-throughput

0.437

High

227132

SUV92
Histone-lysine N-methyltransferase SUV39H2

1

1

High-throughput

0.437

High

227140

COR1C
Coronin-1C

1

4

High-throughput

0.437

High

227145

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.437

High

227114

POC5
Centrosomal protein POC5

1

0

Small-scale

0.426

High

227076

DSCR9
Down syndrome critical region protein 9

1

1

High-throughput

0.417

High

227060

CD27
CD27 antigen

1

2

High-throughput

0.407

High

227070

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.373

High

227113

LIRA3
Leukocyte immunoglobulin-like receptor subfamily A member 3

3

0

High-throughput

0.347

High

227042

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.279

Low

227100

AMTN
Amelotin

1

0

High-throughput

0.279

Low

227105

CNDG2
Condensin-2 complex subunit G2

1

0

High-throughput

0.279

Low

227112

FA24B
Protein FAM24B

1

0

High-throughput

0.279

Low

227138

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

227087

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

227110

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

62423

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low

227043

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

227085

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

227111

RP25L
Ribonuclease P protein subunit p25-like protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025