HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: CDK16 (Q00536)
Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1)
Gene: CDK16

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043005 - neuron projection
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 496
+	Hs
		226557 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CDK2_HUMAN (162-456): 6.05e-145: 418: 53.54
+	Hs
		226265 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CDK1_HUMAN (162-451): 2.98e-136: 397: 51.88
+	Hs
		226887 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CDK7_HUMAN (160-481): 5.55e-132: 387: 37.69
+	Hs
		227181 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CDK5_HUMAN (162-452): 9.2e-133: 387: 55.97
+	Rn
		974746 PRKN_RAT (1-465): 2.14e-136: 402: 85.16		CDK5_RAT (162-452): 3.18e-132: 386: 55.63
+	Hs
		475633 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		CDK17_HUMAN (4-490): 2.31e-154: 451: 68.67
+	At
		1091646 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		MPK4_ARATH (131-490): 4.77e-137: 402: 29.35
+	Hs
		414696 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		CDK1_HUMAN (162-451): 2.98e-136: 397: 51.88
+	At
		1091645 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		MPK3_ARATH (148-483): 4.83e-134: 393: 29.65
+	At
		621654 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CDKA1_ARATH (162-450): 3.28e-135: 393: 54.11