HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: REL (Q04864)
Proto-oncogene c-Rel
Gene: REL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	35509820, 24722188
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0010629 - negative regulation of gene expression GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 619
+	Hs
		312581 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		REL_HUMAN (1-619): 0: 692: 100.00
+	Hs
		227227 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TF65_HUMAN (2-576): 4.74e-158: 466: 37.89
+	Hs
		226494 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NFKB1_HUMAN (1-375): 2e-145: 447: 37.47
+	Hs
		227186 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NFKB2_HUMAN (2-385): 2.1e-133: 414: 34.88
+	Hs
		978884 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		TF65_HUMAN (2-576): 4.74e-158: 466: 37.89
+	Hs
		475001 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		TF65_HUMAN (2-576): 4.74e-158: 466: 37.89
+	Hs
		474999 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		RELB_HUMAN (2-479): 1.52e-143: 430: 35.04
+	Hs
		474996 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		NFKB2_HUMAN (2-385): 2.1e-133: 414: 34.88
+	Hs
		475649 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TF65_HUMAN (2-576): 4.74e-158: 466: 37.89
+	Hs
		226120 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SC31A_HUMAN (266-590): 1.42e-36: 148: 11.11
+	Hs
		475636 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		NFKB2_HUMAN (2-385): 2.1e-133: 414: 34.88
+	Hs
		229228 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PCLO_HUMAN (274-525): 1.16e-09: 63.8: 11.46
+	Hs
		475771 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		NFAC4_HUMAN (1-491): 7.19e-90: 299: 14.43
+	Hs
		302333 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		SC31A_HUMAN (266-590): 1.42e-36: 148: 11.11
+	Hs
		302245 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SC31A_HUMAN (266-590): 1.42e-36: 148: 11.11
+	At
		1092316 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		SC24A_ARATH (295-553): 7.09e-11: 67.7: 7.90