Interactor 1: SPOP (O43791)
Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1)
Gene: SPOP
Interactor 2: GLI3 (P10071)
Transcriptional activator GLI3 (GLI3 form of 190 kDa) (GLI3-190) (GLI3 full-length protein) (GLI3FL) [Cleaved into: Transcriptional repressor GLI3R (GLI3 C-terminally truncated form) (GLI3 form of 83 kDa) (GLI3-83)]
Gene: GLI3
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.92 | 0.60 | 0.745 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 26475525, 27220849, 28805822, 29996942, 31911863, 34021128, 35140242, 34610962 |
| Identification Methods | x-ray crystallography, unspecified method, enzymatic study, two hybrid, affinity chromatography technology |
| Interaction Type | association, direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016607 - nuclear speck |
| Homologous interactions | 5 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
