Protein: GLI3
Transcriptional activator GLI3 (GLI3 form of 190 kDa) (GLI3-190) (GLI3 full-length protein) (GLI3FL) [Cleaved into: Transcriptional repressor GLI3R (GLI3 C-terminally truncated form) (GLI3 form of 83 kDa) (GLI3-83)]

Gene: GLI3
Organism: Homo sapiens
Interactions: 73
UniProt ID: P10071

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001649 - osteoblast differentiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

249333

ZIC3
Zinc finger protein ZIC 3

2

20

Small-scale

0.778

High

227332

SPOP
Speckle-type POZ protein

8

5

Small-scale

0.745

High

336214

ZIC2
Zinc finger protein ZIC 2

1

18

Small-scale

0.724

High

517533

ZIC1
Zinc finger protein ZIC 1

1

18

Small-scale

0.724

High

517562

SUFU
Suppressor of fused homolog

4

11

Small-scale

0.697

High

517514

CSK22
Casein kinase II subunit alpha'

1

4

High-throughput

0.691

High

517565

FBW1A
F-box/WD repeat-containing protein 1A

3

9

Small-scale

0.670

High

517558

STK36
Serine/threonine-protein kinase 36

1

5

Small-scale

0.665

High

517549

CBP
CREB-binding protein

3

15

Small-scale

0.665

High

517513

KPCA
Protein kinase C alpha type

1

2

Small-scale

0.647

High

517519

KC1A
Casein kinase I isoform alpha

1

3

Small-scale

0.647

High

517520

GSK3A
Glycogen synthase kinase-3 alpha

1

2

Small-scale

0.647

High

517444

GLI2
Zinc finger protein GLI2

1

17

High-throughput

0.646

High

517517

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.646

High

289109

PRDM1
PR domain zinc finger protein 1

1

18

Small-scale

0.618

High

466619

GLI1
Zinc finger protein GLI1

1

18

Small-scale

0.618

High

517563

CELA1
Chymotrypsin-like elastase family member 1

2

0

High-throughput

0.602

High

517511

SKI
Ski oncogene

1

3

Small-scale

0.573

High

64847

RCCD1
RCC1 domain-containing protein 1

1

1

High-throughput

0.536

High

517518

SOX2
Transcription factor SOX-2

1

14

High-throughput

0.536

High

517535

KIF7
Kinesin-like protein KIF7

1

4

High-throughput

0.536

High

517555

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.536

High

517551

MED12
Mediator of RNA polymerase II transcription subunit 12

1

5

Small-scale

0.527

High

517534

TAF9
Transcription initiation factor TFIID subunit 9

1

2

Small-scale

0.501

High

517542

RHOU
Rho-related GTP-binding protein RhoU

1

6

High-throughput

0.501

High

517524

RS11
Small ribosomal subunit protein uS17

1

1

High-throughput

0.500

High

517526

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

1

3

High-throughput

0.500

High

517529

EMX1
Homeobox protein EMX1

1

9

Small-scale

0.500

High

517553

WDR11
WD repeat-containing protein 11

1

1

Small-scale

0.500

High

517509

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.479

High

517521

NU107
Nuclear pore complex protein Nup107

1

0

High-throughput

0.479

High

63943

CNOT1
CCR4-NOT transcription complex subunit 1

1

1

High-throughput

0.479

High

160041

CHD1
Chromodomain-helicase-DNA-binding protein 1

1

5

High-throughput

0.479

High

273810

CNOT3
CCR4-NOT transcription complex subunit 3

1

2

High-throughput

0.479

High

274085

ANR17
Ankyrin repeat domain-containing protein 17

1

3

High-throughput

0.479

High

342092

BRD1
Bromodomain-containing protein 1

1

6

High-throughput

0.479

High

371007

MYC
Myc proto-oncogene protein

1

2

Small-scale

0.479

High

517508

ANDR
Androgen receptor

1

11

Small-scale

0.479

High

517510

IRF1
Interferon regulatory factor 1

1

1

Small-scale

0.479

High

517512

SKIL
Ski-like protein

1

3

Small-scale

0.479

High

517515

TAF1
Transcription initiation factor TFIID subunit 1

1

12

High-throughput

0.479

High

517516

SP100
Nuclear autoantigen Sp-100

1

10

High-throughput

0.479

High

517522

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

7

High-throughput

0.479

High

517525

RNF4
E3 ubiquitin-protein ligase RNF4

1

15

High-throughput

0.479

High

517527

OTUD4
OTU domain-containing protein 4

1

1

High-throughput

0.479

High

517528

TF65
Transcription factor p65

1

4

High-throughput

0.479

High

517531

HDAC1
Histone deacetylase 1

1

11

Small-scale

0.479

High

517538

CEP85
Centrosomal protein of 85 kDa

1

6

High-throughput

0.479

High

517539

BCOR
BCL-6 corepressor

1

6

High-throughput

0.479

High

517541

SYNE3
Nesprin-3

1

6

High-throughput

0.479

High

517543

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

3

High-throughput

0.479

High

517544

KLHL7
Kelch-like protein 7

1

3

High-throughput

0.479

High

517546

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

6

High-throughput

0.479

High

517547

KDM2B
Lysine-specific demethylase 2B

1

2

High-throughput

0.479

High

517548

PHIP
PH-interacting protein

1

2

High-throughput

0.479

High

517550

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

11

Small-scale

0.479

High

517552

YTHD1
YTH domain-containing family protein 1

1

2

High-throughput

0.479

High

517559

HDAC6
Protein deacetylase HDAC6

1

12

Small-scale

0.479

High

517560

XPO7
Exportin-7

1

7

High-throughput

0.479

High

517561

FBW1B
F-box/WD repeat-containing protein 11

1

8

High-throughput

0.479

High

517564

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

2

High-throughput

0.479

High

517566

YTHD2
YTH domain-containing family protein 2

1

2

High-throughput

0.479

High

517567

MAGD1
Melanoma-associated antigen D1

1

4

High-throughput

0.479

High

517537

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.458

High

517554

CEP44
Centrosomal protein of 44 kDa

1

0

High-throughput

0.458

High

517556

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.458

High

517557

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

517530

LG3BP
Galectin-3-binding protein

1

5

High-throughput

0.457

High

517523

1433E
14-3-3 protein epsilon

1

1

Small-scale

0.445

High

517536

PRC2B
Protein PRRC2B

1

2

High-throughput

0.437

High

517540

THSD4
Thrombospondin type-1 domain-containing protein 4

1

0

High-throughput

0.279

Low

517532

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

High-throughput

0.249

Low

517545

ARL10
ADP-ribosylation factor-like protein 10

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025