Protein: GLI2
Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein)

Gene: GLI2
Organism: Homo sapiens
Interactions: 75
UniProt ID: P10070

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001501 - skeletal system development
GO:0001649 - osteoblast differentiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

517476

ZIC1
Zinc finger protein ZIC 1

1

19

Small-scale

0.724

High

517505

SUFU
Suppressor of fused homolog

4

11

Small-scale

0.696

High

227331

SPOP
Speckle-type POZ protein

4

5

Small-scale

0.680

High

517444

GLI3
Transcriptional activator GLI3

1

17

High-throughput

0.646

High

517478

KIF7
Kinesin-like protein KIF7

2

5

High-throughput

0.628

High

517507

FBW1A
F-box/WD repeat-containing protein 1A

2

10

Small-scale

0.619

High

336213

ZIC2
Zinc finger protein ZIC 2

1

18

Small-scale

0.618

High

517451

EGR1
Early growth response protein 1

1

17

High-throughput

0.618

High

517492

ZN521
Zinc finger protein 521

1

2

Small-scale

0.618

High

517500

STK36
Serine/threonine-protein kinase 36

1

5

Small-scale

0.618

High

517472

PTC1
Protein patched homolog 1

2

1

Small-scale

0.584

High

517445

ANDR
Androgen receptor

1

14

Small-scale

0.561

High

517490

OTUB2
Ubiquitin thioesterase OTUB2

1

0

Small-scale

0.537

High

517464

SMAD3
Mothers against decapentaplegic homolog 3

1

8

Small-scale

0.536

High

517482

CARM1
Histone-arginine methyltransferase CARM1

1

6

High-throughput

0.536

High

517497

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.536

High

517448

SKI
Ski oncogene

1

3

Small-scale

0.527

High

517495

ASHWN
Ashwin

1

0

High-throughput

0.513

High

517449

CREB1
Cyclic AMP-responsive element-binding protein 1

1

4

Small-scale

0.501

High

517477

TAF9
Transcription initiation factor TFIID subunit 9

1

2

Small-scale

0.501

High

517494

TS101
Tumor susceptibility gene 101 protein

1

1

High-throughput

0.501

High

343882

HS74L
Heat shock 70 kDa protein 4L

1

8

High-throughput

0.500

High

517450

PRS6A
26S proteasome regulatory subunit 6A

1

1

High-throughput

0.500

High

517474

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

7

High-throughput

0.500

High

517486

ZSC18
Zinc finger and SCAN domain-containing protein 18

1

19

High-throughput

0.500

High

517487

HS105
Heat shock protein 105 kDa

1

10

High-throughput

0.500

High

517475

SMAD2
Mothers against decapentaplegic homolog 2

1

8

Small-scale

0.484

High

517453

PSA3
Proteasome subunit alpha type-3

1

0

High-throughput

0.479

High

517455

PRS7
26S proteasome regulatory subunit 7

1

0

High-throughput

0.479

High

517479

MIDN
Midnolin

1

0

High-throughput

0.479

High

517493

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

0

High-throughput

0.479

High

63942

CNOT1
CCR4-NOT transcription complex subunit 1

1

1

High-throughput

0.479

High

273809

CNOT3
CCR4-NOT transcription complex subunit 3

1

2

High-throughput

0.479

High

324085

CE152
Centrosomal protein of 152 kDa

1

3

High-throughput

0.479

High

517454

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

7

High-throughput

0.479

High

517459

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

2

High-throughput

0.479

High

517460

SUMO1
Small ubiquitin-related modifier 1

1

1

High-throughput

0.479

High

517461

UBC9
SUMO-conjugating enzyme UBC9

1

4

High-throughput

0.479

High

517462

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

9

High-throughput

0.479

High

517463

RNF4
E3 ubiquitin-protein ligase RNF4

1

14

High-throughput

0.479

High

517465

XIAP
E3 ubiquitin-protein ligase XIAP

1

1

Small-scale

0.479

High

517467

TLE3
Transducin-like enhancer protein 3

1

8

High-throughput

0.479

High

517470

HDAC1
Histone deacetylase 1

1

11

Small-scale

0.479

High

517471

CUL3
Cullin-3

1

20

Small-scale

0.479

High

517480

A16L1
Autophagy-related protein 16-1

1

7

High-throughput

0.479

High

517481

CEP85
Centrosomal protein of 85 kDa

1

6

High-throughput

0.479

High

517484

KDM2B
Lysine-specific demethylase 2B

1

2

High-throughput

0.479

High

517485

COP1
E3 ubiquitin-protein ligase COP1

1

3

High-throughput

0.479

High

517489

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

11

Small-scale

0.479

High

517501

HDAC6
Protein deacetylase HDAC6

1

12

Small-scale

0.479

High

517502

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

1

Small-scale

0.479

High

517503

FBW1B
F-box/WD repeat-containing protein 11

1

9

Small-scale

0.479

High

517506

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

2

High-throughput

0.479

High

193188

SOCS1
Suppressor of cytokine signaling 1

1

0

Small-scale

0.458

High

289916

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

517446

BCL2
Apoptosis regulator Bcl-2

1

0

Small-scale

0.458

High

517452

FST
Follistatin

1

0

Small-scale

0.458

High

517473

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.458

High

517488

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.458

High

517498

GRPE1
GrpE protein homolog 1, mitochondrial

1

0

High-throughput

0.458

High

517499

M1IP1
Mid1-interacting protein 1

1

0

High-throughput

0.458

High

517468

LG3BP
Galectin-3-binding protein

1

5

High-throughput

0.457

High

346822

BAG2
BAG family molecular chaperone regulator 2

1

5

High-throughput

0.445

High

517447

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.445

High

517458

1433Z
14-3-3 protein zeta/delta

1

2

Small-scale

0.445

High

517466

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

2

High-throughput

0.445

High

517469

SMAD4
Mothers against decapentaplegic homolog 4

1

8

Small-scale

0.445

High

517504

PNMA2
Paraneoplastic antigen Ma2

1

3

High-throughput

0.445

High

517483

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

3

High-throughput

0.437

High

517457

MLH1
DNA mismatch repair protein Mlh1

1

0

High-throughput

0.426

High

517491

CPNE2
Copine-2

1

0

High-throughput

0.426

High

517496

CPVL
Probable serine carboxypeptidase CPVL

1

0

High-throughput

0.261

Low

477097

IL6RA
Interleukin-6 receptor subunit alpha

1

0

Small-scale

0.249

Low

515770

RGPD1
RANBP2-like and GRIP domain-containing protein 1

1

0

High-throughput

0.249

Low

517456

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025