HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: NEDD8 (Q15843)
NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)
Gene: NEDD8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	34642328
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ubiquitin~ubiquitin, ubiquitin~zf-RING_12, ubiquitin~zf-RING_14
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 81
+	Hs
		227107 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14
+	Hs
		227108 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RL40_HUMAN (1-76): 3.79e-33: 112: 57.90
+	Hs
		226334 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		UBB_HUMAN (1-76): 2.4e-30: 107: 57.90
+	Hs
		475094 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		UBB_HUMAN (1-76): 2.4e-30: 107: 57.90
+	Hs
		1079540 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	Hs
		1079643 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	Hs
		312457 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		UBB_HUMAN (1-76): 2.4e-30: 107: 57.90
+	Hs
		312613 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	Hs
		475069 RN19B_HUMAN (220-460): 6.9e-59: 207: 19.18		UBB_HUMAN (1-76): 2.4e-30: 107: 57.90
+	Sc
		408224 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		RS31_YEAST (1-70): 3.03e-30: 105: 52.86
+	Hs
		474985 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		RL40_HUMAN (1-76): 3.79e-33: 112: 57.90
+	Hs
		474899 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		UBB_HUMAN (1-76): 2.4e-30: 107: 57.90
+	Hs
		475036 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	Hs
		475590 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RS27A_HUMAN (1-77): 6.66e-37: 122: 57.14
+	Hs
		475591 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RL40_HUMAN (1-76): 3.79e-33: 112: 57.90
+	Dm
		574862 Q9W418_DROME (1-77): 5.42e-30: 124: 32.47		RL40_DROME (1-76): 1.76e-33: 112: 57.90
+	Pf
		1181539 Q7KQK2_PLAF7 (1-76): 8.17e-31: 124: 28.95		Q7KQK2_PLAF7 (1-76): 5.8e-29: 107: 59.21
+	Hs
		475818 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	At
		96040 UBQ10_ARATH (1-76): 2.29e-29: 121: 31.58		F4I9X6_ARATH (1-77): 3.29e-22: 88.7: 43.96