HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	35509820, 35987950, 35256949
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 551
+	Hs
		226905 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93
+	Hs
		228053 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		227354 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		226120 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SC31A_HUMAN (127-488): 4.72e-28: 121: 14.25
+	Hs
		226375 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		312615 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		228678 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP3_HUMAN (82-518): 1.28e-22: 103: 15.56
+	Hs
		227642 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PAP1L_HUMAN (81-485): 1.03e-19: 94.6: 12.53
+	Hs
		229228 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PCLO_HUMAN (131-447): 2.08e-14: 78.8: 12.23
+	Hs
		226957 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SC24C_HUMAN (233-440): 1.79e-12: 72.2: 17.05
+	Hs
		228623 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WDR33_HUMAN (180-396): 5.21e-09: 61.5: 24.69
+	Hs
		228928 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		OGFR_HUMAN (170-417): 4.4e-09: 61.1: 21.76
+	Hs
		1031383 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		312519 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98
+	Hs
		302333 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		SC31A_HUMAN (127-488): 4.72e-28: 121: 14.25
+	Hs
		312462 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		312672 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		OGFR_HUMAN (170-417): 4.4e-09: 61.1: 21.76
+	Hs
		475708 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		302245 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SC31A_HUMAN (127-488): 4.72e-28: 121: 14.25
+	Hs
		475288 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40