Protein: RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor)

Gene: RPR1B, RPRD1B
Organism: Homo sapiens
Interactions: 193
UniProt ID: Q9NQG5

Gene Ontology (top 5):
GO:0000993 - RNA polymerase II complex binding
GO:0001111 - RNA polymerase II promoter clearance
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0008284 - positive regulation of cell population proliferation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1399361

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

9

13

Small-scale

0.975

High

667471

RPB1
DNA-directed RNA polymerase II subunit RPB1

7

17

Small-scale

0.968

High

1217620

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

5

16

High-throughput

0.925

High

1447079

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

3

12

Small-scale

0.873

High

1313056

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

6

3

Small-scale

0.739

High

723103

RPB2
DNA-directed RNA polymerase II subunit RPB2

6

14

High-throughput

0.735

High

621759

RPB3
DNA-directed RNA polymerase II subunit RPB3

6

12

High-throughput

0.732

High

192863

RPB4
DNA-directed RNA polymerase II subunit RPB4

5

6

High-throughput

0.716

High

316323

RECQ5
ATP-dependent DNA helicase Q5

5

8

High-throughput

0.716

High

912242

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

5

3

High-throughput

0.716

High

976158

RPB7
DNA-directed RNA polymerase II subunit RPB7

5

8

High-throughput

0.716

High

959063

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

5

4

High-throughput

0.712

High

621978

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

4

5

High-throughput

0.699

High

787794

RPB9
DNA-directed RNA polymerase II subunit RPB9

4

8

High-throughput

0.699

High

983712

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

4

3

High-throughput

0.694

High

1270336

SPT6H
Transcription elongation factor SPT6

4

4

High-throughput

0.691

High

1439332

GPN1
GPN-loop GTPase 1

4

6

High-throughput

0.691

High

1447107

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

4

2

High-throughput

0.691

High

130619

SPT5H
Transcription elongation factor SPT5

3

5

High-throughput

0.667

High

355305

ACL6A
Actin-like protein 6A

3

4

High-throughput

0.667

High

316447

RMP
Unconventional prefoldin RPB5 interactor 1

3

2

Small-scale

0.633

High

681933

RBTN2
Rhombotin-2

2

3

High-throughput

0.628

High

1358204

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

1

High-throughput

0.628

High

1395771

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

2

1

High-throughput

0.628

High

1447105

STRAP
Serine-threonine kinase receptor-associated protein

2

3

High-throughput

0.628

High

326381

SCAF4
SR-related and CTD-associated factor 4

1

3

High-throughput

0.618

High

1232025

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

4

3

High-throughput

0.617

High

506033

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

3

3

High-throughput

0.611

High

923545

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

2

4

High-throughput

0.611

High

1447100

GPN3
GPN-loop GTPase 3

3

6

High-throughput

0.609

High

63265

VP37C
Vacuolar protein sorting-associated protein 37C

2

4

High-throughput

0.606

High

164648

TNPO2
Transportin-2

2

1

High-throughput

0.606

High

478342

HXC4
Homeobox protein Hox-C4

2

1

High-throughput

0.606

High

965586

NTF2
Nuclear transport factor 2

2

1

High-throughput

0.606

High

1210148

VAX1
Ventral anterior homeobox 1

2

2

High-throughput

0.606

High

1445889

HM20A
High mobility group protein 20A

2

8

High-throughput

0.606

High

912133

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

2

4

High-throughput

0.601

High

1435878

SFR19
Splicing factor, arginine/serine-rich 19

2

10

High-throughput

0.601

High

1435175

RPAP3
RNA polymerase II-associated protein 3

3

3

High-throughput

0.593

High

1447085

PDRG1
p53 and DNA damage-regulated protein 1

3

2

High-throughput

0.593

High

260495

BRD4
Bromodomain-containing protein 4

2

4

High-throughput

0.584

High

373231

MYC
Myc proto-oncogene protein

2

8

High-throughput

0.584

High

980386

H4
Histone H4

2

3

High-throughput

0.584

High

633804

PSB1
Proteasome subunit beta type-1

2

0

High-throughput

0.580

High

1006174

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

2

0

High-throughput

0.580

High

1200151

BOREA
Borealin

2

0

High-throughput

0.580

High

1434734

STEEP
STING ER exit protein

2

0

High-throughput

0.580

High

321876

PCF11
Pre-mRNA cleavage complex 2 protein Pcf11

1

5

High-throughput

0.575

High

387900

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

1

High-throughput

0.574

High

1447089

ASB6
Ankyrin repeat and SOCS box protein 6

2

2

High-throughput

0.574

High

1447088

PIHD1
PIH1 domain-containing protein 1

2

2

High-throughput

0.571

High

1447096

UXT
Protein UXT

2

2

High-throughput

0.571

High

827935

STAT3
Signal transducer and activator of transcription 3

1

0

Small-scale

0.537

High

132319

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

4

High-throughput

0.536

High

180937

TIF1A
Transcription intermediary factor 1-alpha

1

10

High-throughput

0.536

High

478219

SNRPA
U1 small nuclear ribonucleoprotein A

1

10

High-throughput

0.536

High

480317

RU1C
U1 small nuclear ribonucleoprotein C

1

3

High-throughput

0.536

High

542234

TOP1
DNA topoisomerase 1

1

3

High-throughput

0.536

High

574484

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

3

High-throughput

0.536

High

775327

FUS
RNA-binding protein FUS

1

11

High-throughput

0.536

High

861793

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

4

High-throughput

0.536

High

974057

RUXF
Small nuclear ribonucleoprotein F

1

4

High-throughput

0.536

High

1025229

HXC5
Homeobox protein Hox-C5

1

1

High-throughput

0.536

High

1065444

SSRP1
FACT complex subunit SSRP1

1

8

High-throughput

0.536

High

1160313

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

5

High-throughput

0.536

High

1163226

H2B2E
Histone H2B type 2-E

1

8

High-throughput

0.536

High

1315653

RN168
E3 ubiquitin-protein ligase RNF168

1

1

High-throughput

0.536

High

1316999

FAM9B
Protein FAM9B

1

1

High-throughput

0.536

High

1334958

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.536

High

1338772

ARI1B
AT-rich interactive domain-containing protein 1B

1

1

High-throughput

0.536

High

1368393

REQU
Zinc finger protein ubi-d4

1

6

High-throughput

0.536

High

1407422

EPAS1
Endothelial PAS domain-containing protein 1

1

2

High-throughput

0.536

High

1434429

GSX1
GS homeobox 1

1

2

High-throughput

0.536

High

1447080

ANLN
Anillin

1

1

High-throughput

0.536

High

1447084

CENPM
Centromere protein M

1

1

High-throughput

0.536

High

1150000

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.529

High

1398614

DAA10
Dynein axonemal assembly factor 10

2

2

High-throughput

0.521

High

1447095

PHRF1
PHD and RING finger domain-containing protein 1

2

13

High-throughput

0.521

High

442813

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.513

High

1109397

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

High-throughput

0.513

High

276726

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

1

1

High-throughput

0.489

High

347354

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.489

High

451451

NFM
Neurofilament medium polypeptide

1

1

High-throughput

0.489

High

611984

RL35A
Large ribosomal subunit protein eL33

1

1

High-throughput

0.489

High

706323

S10A2
Protein S100-A2

1

4

High-throughput

0.489

High

1447101

DJC12
DnaJ homolog subfamily C member 12

1

3

High-throughput

0.489

High

1447108

WIF1
Wnt inhibitory factor 1

1

2

High-throughput

0.489

High

186664

HMGB3
High mobility group protein B3

1

5

High-throughput

0.481

High

993763

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.481

High

165096

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

17

High-throughput

0.479

High

180408

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

12

High-throughput

0.479

High

191111

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

5

High-throughput

0.479

High

243021

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

248101

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

256996

H2B1K
Histone H2B type 1-K

1

8

High-throughput

0.479

High

287483

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

2

High-throughput

0.479

High

316046

RECQ4
ATP-dependent DNA helicase Q4

1

8

High-throughput

0.479

High

340040

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

17

High-throughput

0.479

High

404452

GCR
Glucocorticoid receptor

1

11

High-throughput

0.479

High

430650

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

2

High-throughput

0.479

High

520394

ANDR
Androgen receptor

1

11

High-throughput

0.479

High

566052

EF2
Elongation factor 2

1

3

High-throughput

0.479

High

589777

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

607132

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

656245

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

4

High-throughput

0.479

High

696593

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

715797

MARCS
Myristoylated alanine-rich C-kinase substrate

1

2

High-throughput

0.479

High

754998

H2B1B
Histone H2B type 1-B

1

8

High-throughput

0.479

High

769262

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

786867

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

3

High-throughput

0.479

High

799496

BRCA1
Breast cancer type 1 susceptibility protein

1

9

High-throughput

0.479

High

831483

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

891810

GSK3B
Glycogen synthase kinase-3 beta

1

4

High-throughput

0.479

High

964465

SUMO2
Small ubiquitin-related modifier 2

1

3

High-throughput

0.479

High

981118

H2B1C
Histone H2B type 1-C/E/F/G/I

1

8

High-throughput

0.479

High

1010380

BASP1
Brain acid soluble protein 1

1

1

High-throughput

0.479

High

1033251

EWS
RNA-binding protein EWS

1

9

High-throughput

0.479

High

1067748

EP300
Histone acetyltransferase p300

1

5

Small-scale

0.479

High

1107241

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

1125236

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

4

Small-scale

0.479

High

1196917

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

1

High-throughput

0.479

High

1276830

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

1280525

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

4

High-throughput

0.479

High

1329891

SIR6
NAD-dependent protein deacylase sirtuin-6

1

4

High-throughput

0.479

High

1367360

ESR2
Estrogen receptor beta

1

11

High-throughput

0.479

High

1368762

SYMPK
Symplekin

1

3

High-throughput

0.479

High

1385633

DCPS
m7GpppX diphosphatase

1

2

High-throughput

0.479

High

1410699

BCL7B
B-cell CLL/lymphoma 7 protein family member B

1

1

High-throughput

0.479

High

1413632

MED10
Mediator of RNA polymerase II transcription subunit 10

1

3

High-throughput

0.479

High

1428637

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

2

High-throughput

0.479

High

1436803

WDR76
WD repeat-containing protein 76

1

5

High-throughput

0.479

High

1437311

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

14

High-throughput

0.479

High

1447086

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

2

High-throughput

0.479

High

1447087

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

14

High-throughput

0.479

High

1447090

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

2

High-throughput

0.479

High

1447091

WWOX
WW domain-containing oxidoreductase

1

5

High-throughput

0.479

High

1447094

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

8

High-throughput

0.479

High

1447097

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1447099

PFD2
Prefoldin subunit 2

1

2

High-throughput

0.479

High

1447103

FBW1A
F-box/WD repeat-containing protein 1A

1

1

High-throughput

0.479

High

1447106

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

8

High-throughput

0.479

High

1270729

Q7KZS0
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.470

High

1447083

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.460

High

361360

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.458

High

459762

PROF1
Profilin-1

1

0

High-throughput

0.458

High

635805

PTMS
Parathymosin

1

0

High-throughput

0.458

High

698037

CALR
Calreticulin

1

0

High-throughput

0.458

High

785862

8ODP
Oxidized purine nucleoside triphosphate hydrolase

1

0

Small-scale

0.458

High

1095812

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.458

High

1122354

SCRIB
Protein scribble homolog

1

0

Small-scale

0.458

High

1438353

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

330329

VENTX
Homeobox protein VENTX

1

1

High-throughput

0.445

High

564412

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

911395

IMA5
Importin subunit alpha-5

1

2

High-throughput

0.445

High

1007788

RAE1L
mRNA export factor RAE1

1

2

High-throughput

0.445

High

1405499

SCAFB
Protein SCAF11

1

8

High-throughput

0.445

High

1437341

LN28A
Protein lin-28 homolog A

1

6

High-throughput

0.445

High

1447102

CHIP
E3 ubiquitin-protein ligase CHIP

1

3

High-throughput

0.445

High

1447098

GCP4
Gamma-tubulin complex component 4

1

1

High-throughput

0.439

High

375985

RASK
GTPase KRas

1

3

High-throughput

0.437

High

566846

PDIA4
Protein disulfide-isomerase A4

1

1

High-throughput

0.437

High

1255673

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.437

High

1433973

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

369211

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.426

High

1385394

ARMC5
Armadillo repeat-containing protein 5

1

0

High-throughput

0.426

High

1416720

OSB11
Oxysterol-binding protein-related protein 11

1

0

High-throughput

0.426

High

1415622

Q9BVR6
Gamma-tubulin complex component

1

1

High-throughput

0.417

High

142422

PEX7
Peroxisomal targeting signal 2 receptor

1

5

High-throughput

0.407

High

505982

MYZAP
Myocardial zonula adherens protein

1

3

High-throughput

0.407

High

1227514

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.407

High

1396581

C170L
Cep170-like protein

1

1

High-throughput

0.407

High

1447104

KLH20
Kelch-like protein 20

2

0

High-throughput

0.328

High

1328447

S2541
Mitochondrial carrier protein SCaMC-3L

2

0

High-throughput

0.318

High

182189

PFD6
Prefoldin subunit 6

2

0

High-throughput

0.316

High

1292472

RASF3
Ras association domain-containing protein 3

2

0

High-throughput

0.316

High

1386889

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.316

High

1447082

BIN3
Bridging integrator 3

2

0

High-throughput

0.316

High

1447092

SPG21
Maspardin

2

0

High-throughput

0.316

High

1436870

ARMT1
Damage-control phosphatase ARMT1

2

0

High-throughput

0.305

High

343160

CXL14
C-X-C motif chemokine 14

1

0

High-throughput

0.279

Low

476197

ANXA5
Annexin A5

1

0

High-throughput

0.279

Low

1214379

SYT6
Synaptotagmin-6

1

0

High-throughput

0.279

Low

1410529

KXDL1
KxDL motif-containing protein 1

1

0

High-throughput

0.279

Low

157889

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

599629

STMN1
Stathmin

1

0

High-throughput

0.249

Low

959264

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.249

Low

1252984

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low

1447093

CHMP5
Charged multivesicular body protein 5

1

0

High-throughput

0.249

Low

1104121

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

1382669

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.232

Low

1401198

OR4K3
Olfactory receptor 4K3

1

0

High-throughput

0.232

Low

1447081

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025