HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: HIF1A (Q16665)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
Gene: HIF1A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.634

The method score is based on:

Property	Details
Experiments	29180628, 30784061
Identification Methods	affinity chromatography technology, pull down, enzymatic study
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010628 - positive regulation of gene expression GO:0010629 - negative regulation of gene expression and 10 others more... GO:0016607 - nuclear speck GO:0019899 - enzyme binding GO:0019901 - protein kinase binding GO:0031625 - ubiquitin protein ligase binding GO:0034599 - cellular response to oxidative stress GO:0042826 - histone deacetylase binding GO:0045944 - positive regulation of transcription by RNA polymerase II GO:1901526 - positive regulation of mitophagy GO:1903377 - negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:2000378 - negative regulation of reactive oxygen species metabolic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	465
Hs

1	826

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024