HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: SUMO4 (Q6EEV6)
Small ubiquitin-related modifier 4 (SUMO-4) (Small ubiquitin-like protein 4)
Gene: SUMO4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35987950, 35256949
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0034599 - cellular response to oxidative stress GO:0043388 - positive regulation of DNA binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 95
+	Hs
		227117 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SUMO1_HUMAN (1-93): 4.7e-35: 116: 38.14
+	Hs
		474981 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		SUMO2_HUMAN (1-95): 4.5e-41: 132: 85.26
+	Hs
		475562 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SUMO2_HUMAN (1-95): 4.5e-41: 132: 85.26
+	Hs
		475534 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SUMO3_HUMAN (1-94): 3.49e-38: 124: 82.98
+	Hs
		475598 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SUMO1_HUMAN (1-93): 4.7e-35: 116: 38.14