HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: TMTC3 (Q6ZXV5)
Protein O-mannosyl-transferase TMTC3 (EC 2.4.1.109) (Protein SMILE) (Transmembrane O-mannosyltransferase targeting cadherins 3) (Transmembrane and tetratricopeptide repeat-containing 3)
Gene: TMTC3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35509820
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0034976 - response to endoplasmic reticulum stress GO:1901800 - positive regulation of proteasomal protein catabolic process
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 915
+	Hs
		228427 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		BBS4_HUMAN (381-683): 3.48e-26: 115: 14.85
+	Hs
		228468 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DNJC7_HUMAN (384-668): 2.67e-22: 103: 13.62
+	Hs
		174471 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		OGT1_HUMAN (363-565): 1.36e-20: 99: 9.22
+	Hs
		227343 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DNJC3_HUMAN (706-894): 1.45e-12: 73.3: 8.42
+	Hs
		226646 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		STIP1_HUMAN (561-914): 2.34e-12: 72.6: 12.47
+	Dm
		1180619 PRKN_DROME (1-463): 3.5e-106: 325: 42.19		Q7KJA9_DROME (380-675): 2.69e-36: 150: 17.28
+	Hs
		226108 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TOM70_HUMAN (380-585): 2.52e-10: 66: 10.63
+	Hs
		227803 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CTR9_HUMAN (376-578): 1.15e-09: 64.5: 12.38
+	Dm
		284375 ARI2_DROME (228-464): 7.29e-69: 229: 20.92		Q7KJA9_DROME (380-675): 2.69e-36: 150: 17.28
+	Hs
		174509 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		OGT1_HUMAN (363-565): 1.36e-20: 99: 9.22
+	Pf
		1181548 Q7KQK2_PLAF7 (1-76): 8.17e-31: 124: 28.95		HSOP_PLAF7 (371-878): 4.54e-44: 170: 14.49
+	Hs
		476163 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TTC28_HUMAN (327-797): 3.93e-28: 124: 13.17
+	At
		1091830 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		Y2245_ARATH (598-804): 2.04e-21: 102: 21.23
+	At
		187645 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		Y1515_ARATH (598-804): 2.45e-21: 102: 20.76
+	Hs
		174570 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		OGT1_HUMAN (363-565): 1.36e-20: 99: 9.22
+	Hs
		475702 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		DNJC3_HUMAN (706-894): 1.45e-12: 73.3: 8.42