HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: CSN6 (Q7L5N1)
COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP)
Gene: COPS6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	JAB~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 327
+	Hs
		124687 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		EIF3F_HUMAN (10-306): 1.15e-110: 327: 22.07
+	Hs
		226913 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSMD7_HUMAN (37-317): 1.48e-97: 292: 24.48
+	Hs
		176889 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		EIF3H_HUMAN (33-305): 9.03e-59: 194: 14.38
+	Hs
		475966 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Sc
		477476 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		RPN8_YEAST (39-323): 1.95e-84: 260: 22.08
+	Hs
		124740 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		EIF3F_HUMAN (10-306): 1.15e-110: 327: 22.07
+	At
		1091969 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSD7B_ARATH (27-319): 2.9e-100: 299: 24.42
+	At
		188941 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSD7A_ARATH (27-319): 5.69e-100: 298: 24.42
+	At
		1091853 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CSN6A_ARATH (31-316): 2.44e-98: 294: 38.19
+	Hs
		475500 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSMD7_HUMAN (37-317): 1.48e-97: 292: 24.48
+	At
		137953 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		EIF3F_ARATH (28-307): 1.09e-83: 256: 22.34
+	Hs
		176926 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		EIF3H_HUMAN (33-305): 9.03e-59: 194: 14.38
+	At
		1091965 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		EIF3H_ARATH (18-252): 2.76e-52: 177: 14.84
+	At
		1092172 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSDE_ARATH (21-249): 2.46e-51: 173: 12.64