HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: LONP2 (Q86WA8)
Lon protease homolog 2, peroxisomal (EC 3.4.21.53) (Lon protease-like protein 2) (Lon protease 2) (Peroxisomal Lon protease) (pLon)
Gene: LONP2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0019899 - enzyme binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 852
+	Hs
		226700 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		LONM_HUMAN (1-835): 0: 602: 31.18
+	At
		955705 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		LONM1_ARATH (13-835): 0: 613: 31.58
+	At
		249521 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		LONP2_ARATH (7-848): 0: 594: 42.99
+	Hs
		229169 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AFG32_HUMAN (332-733): 7.31e-86: 292: 15.14
+	Hs
		228450 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		YMEL1_HUMAN (121-725): 3.35e-84: 287: 11.95
+	Hs
		226773 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PRS6B_HUMAN (181-592): 2.97e-85: 280: 17.32
+	Hs
		226466 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PRS6A_HUMAN (155-588): 6.85e-83: 274: 13.81
+	Hs
		475255 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AFG32_HUMAN (332-733): 7.31e-86: 292: 15.14
+	Hs
		474950 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		PRS6B_HUMAN (181-592): 2.97e-85: 280: 17.32
+	Sc
		477159 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		CDC48_YEAST (157-635): 2.85e-78: 272: 13.54
+	Hs
		476248 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		YMEL1_HUMAN (121-725): 3.35e-84: 287: 11.95
+	At
		1092294 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CD48D_ARATH (297-788): 2.46e-84: 288: 14.29
+	At
		1091926 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PRS8B_ARATH (211-588): 2.04e-86: 283: 14.07
+	At
		1092219 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CD48E_ARATH (297-788): 2.35e-82: 283: 14.29
+	At
		1091962 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PRS8A_ARATH (226-588): 3.89e-86: 282: 15.69
+	Hs
		475459 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PRS6B_HUMAN (181-592): 2.97e-85: 280: 17.32
+	At
		1092308 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PRS6B_ARATH (203-592): 8.64e-86: 281: 19.17
+	Hs
		475318 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PRS6A_HUMAN (155-588): 6.85e-83: 274: 13.81
+	At
		870955 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CD48A_ARATH (297-788): 4.41e-77: 268: 14.48
+	At
		1092019 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		FTSH5_ARATH (342-716): 4.87e-25: 113: 16.79