HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: MFN1 (Q8IWA4)
Mitofusin-1 (EC 3.6.5.-) (Fzo homolog) (Transmembrane GTPase MFN1)
Gene: MFN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.744

Property	Details
Experiments	29676259, 32246052, 33356389, 21615408, 23060438, 23503661, 24751536
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 741
+	Mm
		1193518 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		MFN2_MOUSE (1-737): 0: 1112: 64.55
+	Hs
		226123 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MFN2_HUMAN (1-737): 0: 1096: 63.46
+	Dm
		1182250 PRKN_DROME (1-463): 3.5e-106: 325: 42.19		MARF_DROME (6-736): 0: 1013: 47.12
+	Hs
		304779 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		MFN2_HUMAN (1-737): 0: 1096: 63.46
+	Dm
		1187269 Q9W418_DROME (1-77): 5.42e-30: 124: 32.47		MARF_DROME (6-736): 0: 1013: 47.12