HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: MIRO2 (Q8IXI1)
Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2)
Gene: RHOT2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.680

Property	Details
Experiments	27605430, 35509820, 23060438, 23503661
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane GO:0007005 - mitochondrion organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 618
+	Hs
		227995 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MIRO1_HUMAN (1-618): 0: 763: 59.65
+	Dm
		1182252 PRKN_DROME (1-463): 3.5e-106: 325: 42.19		MIRO_DROME (2-616): 0: 720: 47.21
+	Hs
		227019 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RAC3_HUMAN (3-168): 9.6e-79: 249: 27.22
+	Hs
		227024 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54
+	Hs
		227513 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RAB35_HUMAN (5-168): 3.51e-76: 242: 24.70
+	Hs
		227168 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RHOG_HUMAN (3-170): 1.68e-74: 238: 27.47
+	Hs
		227111 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RAC1_HUMAN (3-181): 3.15e-74: 237: 26.43
+	Hs
		228651 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RAB1B_HUMAN (416-578): 8.51e-39: 143: 19.05
+	Hs
		226298 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RHOC_HUMAN (6-168): 3.86e-11: 64.3: 28.25
+	Ce
		975578 Q9XUS3_CAEEL (6-464): 2.19e-70: 230: 25.44		RAC1_CAEEL (3-177): 2.15e-73: 235: 25.40
+	Hs
		474987 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		RAC1_HUMAN (3-181): 3.15e-74: 237: 26.43
+	Hs
		918975 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		RAB1A_HUMAN (416-593): 1.56e-40: 148: 18.28
+	Hs
		475548 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54
+	Hs
		475625 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RHOG_HUMAN (3-170): 1.68e-74: 238: 27.47
+	Hs
		475593 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RAC1_HUMAN (3-181): 3.15e-74: 237: 26.43
+	Sc
		350834 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		YPT1_YEAST (416-588): 9.61e-32: 123: 18.54
+	Hs
		474983 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		RHOB_HUMAN (6-168): 4.57e-13: 70.1: 29.38
+	Hs
		475199 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		RHOF_HUMAN (2-167): 3.37e-11: 65.1: 26.67
+	Hs
		916013 RN19A_HUMAN (236-452): 6.6e-31: 128: 21.62		RHOB_HUMAN (6-168): 4.57e-13: 70.1: 29.38
+	Hs
		475558 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RHOA_HUMAN (6-168): 1.74e-11: 65.5: 28.25