HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: MIRO1 (Q8IXI2)
Mitochondrial Rho GTPase 1 (MIRO-1) (hMiro-1) (EC 3.6.5.-) (Rac-GTP-binding protein-like protein) (Ras homolog gene family member T1)
Gene: RHOT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	0.60	0.762

Property	Details
Experiments	30504269, 22396657, 26254304, 25969509, 26116755, 28710279, 28414322, 27605430, 24647965, 28689991, 29676259, 30446597, 35509820, 23060438, 23503661, 22078885
Identification Methods	affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane GO:0007005 - mitochondrion organization GO:0010821 - regulation of mitochondrion organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 618
+	Hs
		227994 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MIRO2_HUMAN (1-618): 0: 764: 59.81
+	Dm
		1182252 PRKN_DROME (1-463): 3.5e-106: 325: 42.19		MIRO_DROME (2-614): 0: 712: 50.94
+	Hs
		476027 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		MIRO2_HUMAN (1-618): 0: 764: 59.81
+	Hs
		227111 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RAC1_HUMAN (3-181): 7.62e-73: 234: 23.83
+	Hs
		227513 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RAB35_HUMAN (5-168): 1.96e-72: 233: 25.90
+	Hs
		228651 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RAB1B_HUMAN (5-172): 2.1e-71: 230: 21.77
+	Hs
		227019 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RAC3_HUMAN (3-168): 4.28e-70: 226: 23.89
+	Hs
		227168 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RHOG_HUMAN (3-170): 8.87e-68: 220: 25.28
+	Hs
		918975 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		RAB1A_HUMAN (5-190): 5.36e-74: 237: 20.21
+	Ce
		975578 Q9XUS3_CAEEL (6-464): 2.19e-70: 230: 25.44		RAC1_CAEEL (3-177): 7.38e-72: 231: 23.81
+	Sc
		350834 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		YPT1_YEAST (5-182): 1.37e-74: 239: 19.44
+	Hs
		474987 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		RAC1_HUMAN (3-181): 7.62e-73: 234: 23.83
+	Hs
		475593 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RAC1_HUMAN (3-181): 7.62e-73: 234: 23.83
+	At
		656930 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		RAD2A_ARATH (5-187): 3.98e-73: 235: 20.54
+	Hs
		475625 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RHOG_HUMAN (3-170): 8.87e-68: 220: 25.28
+	Hs
		475558 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RHOA_HUMAN (6-186): 1.33e-65: 214: 23.59
+	Hs
		475199 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		RHOF_HUMAN (2-167): 3.85e-11: 64.7: 28.33
+	Hs
		474983 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		RHOB_HUMAN (6-168): 6.46e-10: 60.8: 25.99
+	Hs
		916013 RN19A_HUMAN (236-452): 6.6e-31: 128: 21.62		RHOB_HUMAN (6-168): 6.46e-10: 60.8: 25.99
+	Hs
		476409 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RHOF_HUMAN (2-167): 3.85e-11: 64.7: 28.33