HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: TCAB1 (Q9BUR4)
Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta)
Gene: WRAP53

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0044877 - protein-containing complex binding GO:0051087 - protein-folding chaperone binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 548
+	Hs
		227540 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TAF5_HUMAN (263-535): 4.71e-59: 211: 15.44
+	Hs
		228612 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBL1R_HUMAN (274-548): 1.41e-51: 185: 15.41
+	Hs
		196917 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PRP4_HUMAN (305-548): 2.59e-40: 155: 14.74
+	Hs
		228745 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GBB4_HUMAN (103-353): 1.08e-34: 135: 14.63
+	Hs
		227099 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GBB2_HUMAN (341-546): 6.74e-33: 130: 12.62
+	Hs
		226765 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		LIS1_HUMAN (403-544): 1.49e-30: 125: 14.79
+	Hs
		228868 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NLE1_HUMAN (51-257): 2.3e-27: 117: 11.59
+	Hs
		227122 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RACK1_HUMAN (259-482): 1.47e-23: 103: 16.52
+	Hs
		227054 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WDR5_HUMAN (455-548): 1.44e-18: 88.9: 9.57
+	Hs
		228315 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SNR40_HUMAN (445-548): 4.84e-18: 87.7: 11.43
+	Hs
		1334930 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		GBB4_HUMAN (103-353): 1.08e-34: 135: 14.63
+	Sc
		477239 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		TAF5_YEAST (316-534): 2.78e-40: 157: 17.37
+	Hs
		1219356 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		SNR40_HUMAN (445-548): 4.84e-18: 87.7: 11.43
+	Hs
		196947 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PRP4_HUMAN (305-548): 2.59e-40: 155: 14.74
+	Hs
		476404 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		GBB4_HUMAN (103-353): 1.08e-34: 135: 14.63
+	Hs
		475589 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		GBB2_HUMAN (341-546): 6.74e-33: 130: 12.62
+	Hs
		475563 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		WDR5_HUMAN (455-548): 1.44e-18: 88.9: 9.57
+	Hs
		476181 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SNR40_HUMAN (445-548): 4.84e-18: 87.7: 11.43
+	At
		1091956 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		GPLPB_ARATH (140-352): 1.14e-18: 89.1: 18.44
+	At
		187391 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		O22826_ARATH (398-540): 3.65e-17: 85: 12.50