Protein: TMOD3
Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod)

Gene: TMOD3
Organism: Homo sapiens
Interactions: 229
UniProt ID: Q9NYL9

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005523 - tropomyosin binding
GO:0005856 - cytoskeleton
GO:0005865 - striated muscle thin filament
GO:0005912 - adherens junction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

953144

ACTB
Actin, cytoplasmic 1

4

13

High-throughput

0.903

High

995853

ACTC
Actin, alpha cardiac muscle 1

3

11

High-throughput

0.867

High

442495

GELS
Gelsolin

2

12

High-throughput

0.811

High

1093322

FLII
Protein flightless-1 homolog

2

13

High-throughput

0.811

High

1452696

SCIN
Scinderin

2

12

High-throughput

0.811

High

336497

SVIL
Supervillin

2

12

High-throughput

0.726

High

506998

POTEI
POTE ankyrin domain family member I

2

12

High-throughput

0.726

High

977843

ACTA
Actin, aortic smooth muscle

2

12

High-throughput

0.726

High

1201077

ACTBL
Beta-actin-like protein 2

2

12

High-throughput

0.726

High

1447556

MYO5C
Unconventional myosin-Vc

3

7

High-throughput

0.675

High

1361636

SSH1
Protein phosphatase Slingshot homolog 1

3

5

High-throughput

0.662

High

1447355

ANLN
Anillin

3

3

High-throughput

0.656

High

955678

CDC42
Cell division control protein 42 homolog

3

9

High-throughput

0.641

High

273632

PHAR2
Phosphatase and actin regulator 2

2

2

High-throughput

0.628

High

560924

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

2

2

High-throughput

0.628

High

1065805

SPIR1
Protein spire homolog 1

2

1

High-throughput

0.628

High

1181286

LRRF1
Leucine-rich repeat flightless-interacting protein 1

2

7

High-throughput

0.628

High

1233724

TWF2
Twinfilin-2

2

4

High-throughput

0.628

High

1331369

ENAH
Protein enabled homolog

2

2

High-throughput

0.628

High

1359562

SPIR2
Protein spire homolog 2

2

1

High-throughput

0.628

High

1452688

MYO5B
Unconventional myosin-Vb

2

8

High-throughput

0.628

High

1452693

MYO5A
Unconventional myosin-Va

2

8

High-throughput

0.628

High

1177109

INF2
Inverted formin-2

2

0

High-throughput

0.602

High

1160779

DREB
Drebrin

2

2

High-throughput

0.601

High

564456

CFTR
Cystic fibrosis transmembrane conductance regulator

3

2

High-throughput

0.587

High

209345

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

2

2

High-throughput

0.574

High

247173

TBCD4
TBC1 domain family member 4

2

1

High-throughput

0.574

High

653617

HEMH
Ferrochelatase, mitochondrial

2

1

High-throughput

0.574

High

823919

PBX2
Pre-B-cell leukemia transcription factor 2

2

3

High-throughput

0.574

High

920514

DAPK1
Death-associated protein kinase 1

2

4

High-throughput

0.574

High

1394199

LRCH3
DISP complex protein LRCH3

2

4

High-throughput

0.574

High

1398853

DOCK7
Dedicator of cytokinesis protein 7

2

1

High-throughput

0.574

High

1436232

CSR2B
Cysteine-rich protein 2-binding protein

2

1

High-throughput

0.574

High

1452695

LRRF2
Leucine-rich repeat flightless-interacting protein 2

2

13

High-throughput

0.574

High

942926

BCAR1
Breast cancer anti-estrogen resistance protein 1

2

5

High-throughput

0.571

High

123854

MYO1C
Unconventional myosin-Ic

1

15

High-throughput

0.536

High

318406

MYO1D
Unconventional myosin-Id

1

15

High-throughput

0.536

High

530467

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.536

High

773050

MYH9
Myosin-9

1

2

High-throughput

0.536

High

1052110

CALD1
Caldesmon

1

14

High-throughput

0.536

High

1085932

TWF1
Twinfilin-1

1

4

High-throughput

0.536

High

1322392

ABRA
Actin-binding Rho-activating protein

1

2

High-throughput

0.536

High

1325458

SYNPO
Synaptopodin

1

1

High-throughput

0.536

High

1392682

MYO19
Unconventional myosin-XIX

1

10

High-throughput

0.536

High

1404909

PARK7
Parkinson disease protein 7

1

2

High-throughput

0.536

High

397088

ESR1
Estrogen receptor

2

8

Small-scale

0.533

High

425653

ISG15
Ubiquitin-like protein ISG15

2

3

High-throughput

0.533

High

277961

SH3L1
Adapter SH3BGRL

2

1

High-throughput

0.521

High

541720

FGFR1
Fibroblast growth factor receptor 1

2

4

High-throughput

0.521

High

635754

RASA1
Ras GTPase-activating protein 1

2

4

High-throughput

0.521

High

1095061

DUS4
Dual specificity protein phosphatase 4

2

5

High-throughput

0.521

High

998069

CSK21
Casein kinase II subunit alpha

1

3

High-throughput

0.502

High

163477

MEIS2
Homeobox protein Meis2

1

3

High-throughput

0.489

High

607663

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

1

High-throughput

0.489

High

637764

FLNA
Filamin-A

1

4

High-throughput

0.489

High

668047

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.489

High

732723

ARRB2
Beta-arrestin-2

1

1

High-throughput

0.489

High

823865

PBX1
Pre-B-cell leukemia transcription factor 1

1

3

High-throughput

0.489

High

823985

PBX3
Pre-B-cell leukemia transcription factor 3

1

3

High-throughput

0.489

High

863004

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

3

High-throughput

0.489

High

866843

CAZA2
F-actin-capping protein subunit alpha-2

1

4

High-throughput

0.489

High

882573

ARRB1
Beta-arrestin-1

1

1

High-throughput

0.489

High

968465

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

5

High-throughput

0.489

High

1110576

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

1

High-throughput

0.489

High

1258235

UBP45
Ubiquitin carboxyl-terminal hydrolase 45

1

2

High-throughput

0.489

High

1290229

PIM3
Serine/threonine-protein kinase pim-3

1

1

High-throughput

0.489

High

1352227

TBCK
TBC domain-containing protein kinase-like protein

1

2

High-throughput

0.489

High

1365603

MY18A
Unconventional myosin-XVIIIa

1

8

High-throughput

0.489

High

1452687

LIMA1
LIM domain and actin-binding protein 1

1

2

High-throughput

0.489

High

556378

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

765072

CTNB1
Catenin beta-1

1

2

High-throughput

0.479

High

867464

CAPZB
F-actin-capping protein subunit beta

1

4

High-throughput

0.479

High

962842

RND3
Rho-related GTP-binding protein RhoE

1

9

High-throughput

0.479

High

1114474

CUL3
Cullin-3

1

4

High-throughput

0.479

High

1116064

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

5

High-throughput

0.479

High

1209732

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

Small-scale

0.479

High

1253238

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

11

High-throughput

0.479

High

1255841

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

1396643

RHOV
Rho-related GTP-binding protein RhoV

1

10

High-throughput

0.479

High

1419425

RHBT2
Rho-related BTB domain-containing protein 2

1

12

High-throughput

0.479

High

1452685

HDAC6
Protein deacetylase HDAC6

1

4

High-throughput

0.479

High

390785

TFR1
Transferrin receptor protein 1

1

2

High-throughput

0.470

High

1360950

CLC4D
C-type lectin domain family 4 member D

1

5

High-throughput

0.470

High

164703

TNF11
Tumor necrosis factor ligand superfamily member 11

1

1

High-throughput

0.464

High

1415390

DUS23
Dual specificity protein phosphatase 23

1

7

High-throughput

0.464

High

1428392

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

1

High-throughput

0.464

High

1349775

FBX25
F-box only protein 25

1

0

High-throughput

0.458

High

1015850

RHOG
Rho-related GTP-binding protein RhoG

1

8

Small-scale

0.445

High

1452690

COR2B
Coronin-2B

1

6

High-throughput

0.445

High

106748

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

126835

RHOD
Rho-related GTP-binding protein RhoD

1

11

High-throughput

0.437

High

135366

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

1

High-throughput

0.437

High

189013

TMPS2
Transmembrane protease serine 2

1

1

High-throughput

0.437

High

1355905

DUS19
Dual specificity protein phosphatase 19

1

5

High-throughput

0.437

High

223383

PRC1
Protein regulator of cytokinesis 1

1

5

High-throughput

0.437

High

323582

TRI37
E3 ubiquitin-protein ligase TRIM37

1

8

High-throughput

0.437

High

331371

KI20A
Kinesin-like protein KIF20A

1

7

High-throughput

0.437

High

370792

FOS
Protein c-Fos

1

1

High-throughput

0.437

High

373330

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.437

High

376021

RASK
GTPase KRas

1

9

High-throughput

0.437

High

378195

TNFA
Tumor necrosis factor

1

1

High-throughput

0.437

High

406731

MYCN
N-myc proto-oncogene protein

1

7

High-throughput

0.437

High

473139

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

2

High-throughput

0.437

High

520410

ANDR
Androgen receptor

1

7

High-throughput

0.437

High

535604

BIP
Endoplasmic reticulum chaperone BiP

1

8

High-throughput

0.437

High

560540

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.437

High

583110

VATB1
V-type proton ATPase subunit B, kidney isoform

1

1

High-throughput

0.437

High

589880

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

643102

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.437

High

651444

CBL
E3 ubiquitin-protein ligase CBL

1

1

High-throughput

0.437

High

652591

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

7

Small-scale

0.437

High

681056

PSA1
Proteasome subunit alpha type-1

1

1

High-throughput

0.437

High

696698

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

714468

PML
Protein PML

1

4

High-throughput

0.437

High

786892

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

5

High-throughput

0.437

High

838189

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

1

High-throughput

0.437

High

862501

YAP1
Transcriptional coactivator YAP1

1

1

High-throughput

0.437

High

872816

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.437

High

898002

CDK9
Cyclin-dependent kinase 9

1

5

High-throughput

0.437

High

901615

RAB7A
Ras-related protein Rab-7a

1

4

High-throughput

0.437

High

903268

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

3

High-throughput

0.437

High

907604

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

2

High-throughput

0.437

High

908864

NEK2
Serine/threonine-protein kinase Nek2

1

4

Small-scale

0.437

High

930062

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

High-throughput

0.437

High

945109

RAB25
Ras-related protein Rab-25

1

4

High-throughput

0.437

High

976612

RB11A
Ras-related protein Rab-11A

1

4

High-throughput

0.437

High

1031567

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

1035956

KIF23
Kinesin-like protein KIF23

1

3

High-throughput

0.437

High

1085631

FOXO1
Forkhead box protein O1

1

1

High-throughput

0.437

High

1094638

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

2

High-throughput

0.437

High

1096838

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.437

High

1118177

DX39B
Spliceosome RNA helicase DDX39B

1

1

High-throughput

0.437

High

1127202

RBM39
RNA-binding protein 39

1

1

High-throughput

0.437

High

1138114

TNIP1
TNFAIP3-interacting protein 1

1

6

High-throughput

0.437

High

1140949

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.437

High

1155833

EZH2
Histone-lysine N-methyltransferase EZH2

1

4

High-throughput

0.437

High

1161718

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.437

High

1197579

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

3

High-throughput

0.437

High

1245069

TRI65
E3 ubiquitin-protein ligase TRIM65

1

6

Small-scale

0.437

High

1250001

CLC9A
C-type lectin domain family 9 member A

1

6

Small-scale

0.437

High

1286936

TM11B
Transmembrane protease serine 11B

1

1

High-throughput

0.437

High

1289665

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.437

High

1316597

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

2

Small-scale

0.437

High

1328728

FHI1B
FHF complex subunit HOOK-interacting protein 1B

1

1

High-throughput

0.437

High

1339811

TRI58
E3 ubiquitin-protein ligase TRIM58

1

5

Small-scale

0.437

High

1357992

RN138
E3 ubiquitin-protein ligase RNF138

1

7

High-throughput

0.437

High

1358122

NUDC2
NudC domain-containing protein 2

1

3

High-throughput

0.437

High

1360831

ASB11
Ankyrin repeat and SOCS box protein 11

1

7

High-throughput

0.437

High

1367437

ESR2
Estrogen receptor beta

1

7

High-throughput

0.437

High

1380209

FBXW7
F-box/WD repeat-containing protein 7

1

1

Small-scale

0.437

High

1385889

CHM4C
Charged multivesicular body protein 4c

1

5

High-throughput

0.437

High

1391810

AURKB
Aurora kinase B

1

3

High-throughput

0.437

High

1407247

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

1

High-throughput

0.437

High

1433093

CHM4B
Charged multivesicular body protein 4b

1

5

High-throughput

0.437

High

1434071

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.437

High

1436514

ECT2
Protein ECT2

1

11

High-throughput

0.437

High

1450904

RNF12
E3 ubiquitin-protein ligase RLIM

1

2

High-throughput

0.437

High

1452686

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.437

High

1452689

CLC4E
C-type lectin domain family 4 member E

1

5

High-throughput

0.437

High

1452692

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.437

High

255242

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.407

High

387150

TNNC2
Troponin C, skeletal muscle

1

1

High-throughput

0.407

High

765944

BMI1
Polycomb complex protein BMI-1

1

5

High-throughput

0.407

High

800579

VATA
V-type proton ATPase catalytic subunit A

1

3

High-throughput

0.407

High

987984

GRB2
Growth factor receptor-bound protein 2

1

7

High-throughput

0.407

High

1103415

CTBP1
C-terminal-binding protein 1

1

2

High-throughput

0.407

High

1234986

PKHA7
Pleckstrin homology domain-containing family A member 7

1

3

High-throughput

0.407

High

1357252

S38A5
Sodium-coupled neutral amino acid transporter 5

1

1

High-throughput

0.407

High

1429865

TOLIP
Toll-interacting protein

1

1

High-throughput

0.407

High

215200

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

2

0

High-throughput

0.328

High

271184

COBL
Protein cordon-bleu

2

0

High-throughput

0.328

High

1292240

LONP2
Lon protease homolog 2, peroxisomal

2

0

High-throughput

0.328

High

249790

DOK2
Docking protein 2

2

0

High-throughput

0.298

High

317011

MTA2
Metastasis-associated protein MTA2

2

0

High-throughput

0.298

High

186226

PPM1D
Protein phosphatase 1D

1

0

High-throughput

0.279

Low

1161834

ZSC26
Zinc finger and SCAN domain-containing protein 26

1

0

High-throughput

0.279

Low

1270662

COX15
Heme A synthase COX15

1

0

High-throughput

0.279

Low

1353795

HASP
Serine/threonine-protein kinase haspin

1

0

High-throughput

0.279

Low

1404464

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.279

Low

1414702

DHRS6
Dehydrogenase/reductase SDR family member 6

1

0

High-throughput

0.279

Low

1448501

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.279

Low

1451245

FBX34
F-box only protein 34

1

0

High-throughput

0.279

Low

693114

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.269

Low

178423

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.249

Low

248115

NUPR1
Nuclear protein 1

1

0

High-throughput

0.249

Low

277835

H2AY
Core histone macro-H2A.1

1

0

Small-scale

0.249

Low

488879

FURIN
Furin

1

0

High-throughput

0.249

Low

560121

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.249

Low

630061

BTF3
Transcription factor BTF3

1

0

High-throughput

0.249

Low

646953

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.249

Low

718849

CCND2
G1/S-specific cyclin-D2

1

0

Small-scale

0.249

Low

769357

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

831541

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

837874

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.249

Low

971195

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

972067

1433E
14-3-3 protein epsilon

1

0

Small-scale

0.249

Low

998881

H31
Histone H3.1

1

0

High-throughput

0.249

Low

1041707

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

0

Small-scale

0.249

Low

1060238

B2CL1
Bcl-2-like protein 1

1

0

High-throughput

0.249

Low

1086331

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.249

Low

1101064

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.249

Low

1126192

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1135138

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

1197725

MIDN
Midnolin

1

0

High-throughput

0.249

Low

1205496

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.249

Low

1214861

ARM12
Armadillo repeat-containing protein 12

1

0

Small-scale

0.249

Low

1229719

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

1247018

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.249

Low

1276878

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1352794

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.249

Low

1364629

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.249

Low

1390543

CDCA5
Sororin

1

0

High-throughput

0.249

Low

1411499

OVOL2
Transcription factor Ovo-like 2

1

0

Small-scale

0.249

Low

1420965

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.249

Low

1430604

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.249

Low

1438358

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.249

Low

1449229

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.249

Low

1451134

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.249

Low

1452684

SYLC
Leucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.249

Low

1452691

PHOCN
MOB-like protein phocein

1

0

High-throughput

0.249

Low

1452694

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.249

Low

87547

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low

1034075

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

High-throughput

0.232

Low

1214208

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low

1216633

LIN9
Protein lin-9 homolog

1

0

Small-scale

0.232

Low

1338785

NCKX4
Sodium/potassium/calcium exchanger 4

1

0

High-throughput

0.232

Low

1340575

MFSD8
Major facilitator superfamily domain-containing protein 8

1

0

High-throughput

0.232

Low

1405528

ZBT18
Zinc finger and BTB domain-containing protein 18

1

0

High-throughput

0.232

Low

1452414

SPHK1
Sphingosine kinase 1

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025