Protein: BRCC3
Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36)

Gene: BRCC3
Organism: Homo sapiens
Interactions: 94
UniProt ID: P46736

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000152 - nuclear ubiquitin ligase complex
GO:0000922 - spindle pole
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

475467

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

8

13

Small-scale

0.965

High

805530

ABRX2
BRISC complex subunit Abraxas 2

14

3

Small-scale

0.759

High

805537

ABRX1
BRCA1-A complex subunit Abraxas 1

11

3

Small-scale

0.758

High

805565

BABA2
BRISC and BRCA1-A complex member 2

11

1

Small-scale

0.758

High

749203

BRCA1
Breast cancer type 1 susceptibility protein

9

4

Small-scale

0.750

High

805554

UIMC1
BRCA1-A complex subunit RAP80

13

0

Small-scale

0.728

High

805564

BABA1
BRISC and BRCA1-A complex member 1

10

0

Small-scale

0.722

High

713477

GLYM
Serine hydroxymethyltransferase, mitochondrial

4

1

Small-scale

0.697

High

805545

UBL4B
Ubiquitin-like protein 4B

1

9

High-throughput

0.691

High

805553

NLRP3
NACHT, LRR and PYD domains-containing protein 3

4

4

Small-scale

0.676

High

805561

DEFI6
Differentially expressed in FDCP 6 homolog

3

5

High-throughput

0.667

High

125227

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

3

4

Small-scale

0.664

High

805556

BARD1
BRCA1-associated RING domain protein 1

3

5

Small-scale

0.650

High

474952

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

13

Small-scale

0.618

High

803427

BAG6
Large proline-rich protein BAG6

1

10

High-throughput

0.618

High

805510

BRCC3
Lys-63-specific deubiquitinase BRCC36

1

8

Small-scale

0.618

High

805526

CUL3
Cullin-3

1

12

High-throughput

0.618

High

805547

CSN5
COP9 signalosome complex subunit 5

1

16

Small-scale

0.618

High

386280

P53
Cellular tumor antigen p53

2

2

Small-scale

0.606

High

805514

BRCA2
Breast cancer type 2 susceptibility protein

2

0

Small-scale

0.595

High

805517

SUMO2
Small ubiquitin-related modifier 2

2

1

Small-scale

0.595

High

805534

TFDP3
Transcription factor Dp family member 3

2

0

High-throughput

0.585

High

805528

MDC1
Mediator of DNA damage checkpoint protein 1

2

8

High-throughput

0.584

High

666038

SHC1
SHC-transforming protein 1

2

3

High-throughput

0.571

High

805566

UVRAG
UV radiation resistance-associated gene protein

2

0

Small-scale

0.547

High

157186

BACH1
Transcription regulator protein BACH1

1

11

High-throughput

0.541

High

805532

ITSN1
Intersectin-1

1

4

High-throughput

0.541

High

174372

FANCG
Fanconi anemia group G protein

1

0

Small-scale

0.537

High

805529

NUMA1
Nuclear mitotic apparatus protein 1

1

5

Small-scale

0.536

High

331152

DNAL4
Dynein axonemal light chain 4

1

2

High-throughput

0.536

High

566736

JUNB
Transcription factor JunB

1

5

High-throughput

0.536

High

805518

1433G
14-3-3 protein gamma

1

6

High-throughput

0.536

High

805523

1433F
14-3-3 protein eta

1

6

High-throughput

0.536

High

805549

RN166
E3 ubiquitin-protein ligase RNF166

1

4

High-throughput

0.536

High

805563

TENS1
Tensin-1

1

2

High-throughput

0.536

High

280099

SNPC5
snRNA-activating protein complex subunit 5

1

0

High-throughput

0.518

High

805511

ATPO
ATP synthase subunit O, mitochondrial

1

1

High-throughput

0.515

High

805513

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.515

High

805541

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

7

High-throughput

0.515

High

805548

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

2

High-throughput

0.515

High

805570

SP16H
FACT complex subunit SPT16

1

3

High-throughput

0.515

High

471565

TFPT
TCF3 fusion partner

1

0

High-throughput

0.513

High

805512

CENPA
Histone H3-like centromeric protein A

1

0

High-throughput

0.513

High

805524

RAD51
DNA repair protein RAD51 homolog 1

1

0

Small-scale

0.513

High

805515

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

2

Small-scale

0.501

High

311217

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

1

0

High-throughput

0.493

High

805543

EXOC8
Exocyst complex component 8

1

0

High-throughput

0.493

High

805552

CI085
Uncharacterized protein C9orf85

1

1

High-throughput

0.489

High

805560

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.489

High

653087

CD82
CD82 antigen

1

1

Small-scale

0.481

High

805536

ANR11
Ankyrin repeat domain-containing protein 11

1

7

High-throughput

0.481

High

160436

AURKA
Aurora kinase A

1

1

Small-scale

0.479

High

205155

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

294498

RECQ4
ATP-dependent DNA helicase Q4

1

11

High-throughput

0.479

High

326498

SNAI1
Zinc finger protein SNAI1

1

3

Small-scale

0.479

High

373855

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

552168

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

610291

CBL
E3 ubiquitin-protein ligase CBL

1

3

High-throughput

0.479

High

668506

PML
Protein PML

1

5

High-throughput

0.479

High

716858

CTNB1
Catenin beta-1

1

7

Small-scale

0.479

High

719910

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

737637

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

2

High-throughput

0.479

High

805516

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.479

High

805519

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

805520

H4
Histone H4

1

2

High-throughput

0.479

High

805521

GRB2
Growth factor receptor-bound protein 2

1

4

High-throughput

0.479

High

805522

CDK5
Cyclin-dependent kinase 5

1

6

Small-scale

0.479

High

805525

TP53B
TP53-binding protein 1

1

8

High-throughput

0.479

High

805527

TRI14
Tripartite motif-containing protein 14

1

4

High-throughput

0.479

High

805531

E2F5
Transcription factor E2F5

1

2

High-throughput

0.479

High

805535

TENS2
Tensin-2

1

2

High-throughput

0.479

High

805538

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

805539

PAXI1
PAX-interacting protein 1

1

4

High-throughput

0.479

High

805540

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

805542

TRI50
E3 ubiquitin-protein ligase TRIM50

1

2

Small-scale

0.479

High

805546

ESR2
Estrogen receptor beta

1

6

High-throughput

0.479

High

805551

SNX27
Sorting nexin-27

1

6

High-throughput

0.479

High

805555

CRBN
Protein cereblon

1

1

Small-scale

0.479

High

805557

FANCJ
Fanconi anemia group J protein

1

1

Small-scale

0.479

High

805559

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

4

Small-scale

0.479

High

805562

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

805567

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

805568

HERC5
E3 ISG15--protein ligase HERC5

1

6

Small-scale

0.479

High

805571

X5D778
Ankyrin repeat domain 11 isoform A

1

6

High-throughput

0.470

High

176572

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.458

High

805550

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

0

High-throughput

0.458

High

566014

INAR1
Interferon alpha/beta receptor 1

1

3

Small-scale

0.457

High

805569

TNIK
TRAF2 and NCK-interacting protein kinase

1

5

High-throughput

0.457

High

805533

ODFP2
Outer dense fiber protein 2

1

4

High-throughput

0.445

High

87584

C9JYE9
E2F transcription factor 5

1

2

High-throughput

0.437

High

805544

CB073
Uncharacterized protein C2orf73

1

0

High-throughput

0.279

Low

805558

RM01
Large ribosomal subunit protein uL1m

1

0

High-throughput

0.279

Low

762923

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.269

Low


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Last updated: 15 Jul 2024