Protein: PER2
Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2)

Gene: PER2
Organism: Homo sapiens
Interactions: 139
UniProt ID: O15055

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000976 - transcription cis-regulatory region binding
GO:0001222 - transcription corepressor binding
GO:0002931 - response to ischemia
GO:0003713 - transcription coactivator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

165986

CRY1
Cryptochrome-1

9

20

Small-scale

0.968

High

165988

CRY2
Cryptochrome-2

5

20

Small-scale

0.922

High

165890

PER1
Period circadian protein homolog 1

2

20

High-throughput

0.793

High

165951

KC1E
Casein kinase I isoform epsilon

8

20

Small-scale

0.750

High

165949

KC1D
Casein kinase I isoform delta

5

20

Small-scale

0.719

High

166018

FBW1A
F-box/WD repeat-containing protein 1A

5

12

Small-scale

0.711

High

165968

MDM2
E3 ubiquitin-protein ligase Mdm2

3

3

Small-scale

0.674

High

111450

J3QSH9
Period circadian regulator 1

1

19

High-throughput

0.665

High

165903

P53
Cellular tumor antigen p53

2

8

Small-scale

0.651

High

165889

CLOCK
Circadian locomoter output cycles protein kaput

1

19

High-throughput

0.621

High

126088

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

19

Small-scale

0.618

High

165957

PER3
Period circadian protein homolog 3

1

20

Small-scale

0.618

High

166016

FBW1B
F-box/WD repeat-containing protein 11

2

13

High-throughput

0.611

High

165916

UBL4A
Ubiquitin-like protein 4A

2

7

High-throughput

0.606

High

165960

LMO4
LIM domain transcription factor LMO4

2

4

High-throughput

0.606

High

165977

ELOA1
Elongin-A

2

1

High-throughput

0.606

High

165942

MLH1
DNA mismatch repair protein Mlh1

2

0

High-throughput

0.580

High

166005

LENG8
Leukocyte receptor cluster member 8

2

0

High-throughput

0.580

High

165906

JUN
Transcription factor Jun

1

13

High-throughput

0.536

High

165934

CRCM
Colorectal mutant cancer protein

1

11

High-throughput

0.536

High

165969

KIF23
Kinesin-like protein KIF23

1

5

High-throughput

0.536

High

165972

GOGA3
Golgin subfamily A member 3

1

10

High-throughput

0.536

High

165976

PLD1
Phospholipase D1

1

2

High-throughput

0.536

High

165981

GAPD1
GTPase-activating protein and VPS9 domain-containing protein 1

1

4

High-throughput

0.536

High

165989

CEP78
Centrosomal protein of 78 kDa

1

1

High-throughput

0.536

High

165990

ZN618
Zinc finger protein 618

1

2

High-throughput

0.536

High

165994

ACD11
Acyl-CoA dehydrogenase family member 11

1

1

High-throughput

0.536

High

165996

DZIP1
Cilium assembly protein DZIP1

1

11

High-throughput

0.536

High

166000

ASPM
Abnormal spindle-like microcephaly-associated protein

1

11

High-throughput

0.536

High

166001

APBP2
Amyloid protein-binding protein 2

1

4

High-throughput

0.536

High

166004

REXO5
RNA exonuclease 5

1

1

High-throughput

0.536

High

166008

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

1

1

High-throughput

0.536

High

166011

SAV1
Protein salvador homolog 1

1

2

High-throughput

0.536

High

165935

MCM3
DNA replication licensing factor MCM3

1

5

Small-scale

0.515

High

165936

PML
Protein PML

1

13

Small-scale

0.515

High

51089

CBAR1
CBY1-interacting BAR domain-containing protein 1

1

0

High-throughput

0.513

High

165974

WASC5
WASH complex subunit 5

1

0

High-throughput

0.513

High

165987

WASC4
WASH complex subunit 4

1

0

High-throughput

0.513

High

165992

TTLL5
Tubulin polyglutamylase TTLL5

1

0

High-throughput

0.513

High

165993

FA83H
Protein FAM83H

1

0

High-throughput

0.513

High

165917

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

Small-scale

0.493

High

165927

HXK1
Hexokinase-1

1

0

Small-scale

0.493

High

165980

SLMAP
Sarcolemmal membrane-associated protein

1

10

High-throughput

0.489

High

165953

RORG
Nuclear receptor ROR-gamma

1

20

High-throughput

0.481

High

165965

CSK2B
Casein kinase II subunit beta

1

7

High-throughput

0.481

High

166010

BHE41
Class E basic helix-loop-helix protein 41

1

19

High-throughput

0.481

High

159112

CSKP
Peripheral plasma membrane protein CASK

1

0

High-throughput

0.480

High

165891

ACTN4
Alpha-actinin-4

1

3

Small-scale

0.479

High

165893

MAGC1
Melanoma-associated antigen C1

1

13

Small-scale

0.479

High

165895

KPCD3
Serine/threonine-protein kinase D3

1

8

Small-scale

0.479

High

165896

GFPT2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

1

1

Small-scale

0.479

High

165897

NB5R3
NADH-cytochrome b5 reductase 3

1

1

Small-scale

0.479

High

165898

PGK1
Phosphoglycerate kinase 1

1

1

Small-scale

0.479

High

165900

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

3

Small-scale

0.479

High

165904

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

4

Small-scale

0.479

High

165905

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

3

Small-scale

0.479

High

165907

LA
Lupus La protein

1

1

Small-scale

0.479

High

165908

GELS
Gelsolin

1

4

Small-scale

0.479

High

165911

H2B1J
Histone H2B type 1-J

1

1

Small-scale

0.479

High

165912

PDIA1
Protein disulfide-isomerase

1

2

Small-scale

0.479

High

165913

HS90A
Heat shock protein HSP 90-alpha

1

17

Small-scale

0.479

High

165914

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

3

Small-scale

0.479

High

165918

ACTN1
Alpha-actinin-1

1

3

Small-scale

0.479

High

165919

EF2
Elongation factor 2

1

2

Small-scale

0.479

High

165921

ENPL
Endoplasmin

1

17

Small-scale

0.479

High

165922

EZRI
Ezrin

1

2

Small-scale

0.479

High

165923

NDKA
Nucleoside diphosphate kinase A

1

1

Small-scale

0.479

High

165924

HMGA1
High mobility group protein HMG-I/HMG-Y

1

2

Small-scale

0.479

High

165925

KPCA
Protein kinase C alpha type

1

7

Small-scale

0.479

High

165926

EGR1
Early growth response protein 1

1

4

High-throughput

0.479

High

165928

FLNA
Filamin-A

1

4

Small-scale

0.479

High

165931

NDKB
Nucleoside diphosphate kinase B

1

1

Small-scale

0.479

High

165932

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

3

Small-scale

0.479

High

165933

SFPQ
Splicing factor, proline- and glutamine-rich

1

7

Small-scale

0.479

High

165937

HNRH3
Heterogeneous nuclear ribonucleoprotein H3

1

2

Small-scale

0.479

High

165938

SPRE
Sepiapterin reductase

1

1

Small-scale

0.479

High

165939

TAGL2
Transgelin-2

1

2

Small-scale

0.479

High

165943

MDHM
Malate dehydrogenase, mitochondrial

1

2

Small-scale

0.479

High

165945

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

2

Small-scale

0.479

High

165946

MATR3
Matrin-3

1

3

Small-scale

0.479

High

165947

PRS6B
26S proteasome regulatory subunit 6B

1

7

Small-scale

0.479

High

165950

FAS
Fatty acid synthase

1

2

Small-scale

0.479

High

165952

TCPQ
T-complex protein 1 subunit theta

1

3

Small-scale

0.479

High

165954

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

3

Small-scale

0.479

High

165955

TERA
Transitional endoplasmic reticulum ATPase

1

1

Small-scale

0.479

High

165956

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

3

Small-scale

0.479

High

165958

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

2

Small-scale

0.479

High

165962

RAB1A
Ras-related protein Rab-1A

1

1

Small-scale

0.479

High

165964

1433Z
14-3-3 protein zeta/delta

1

4

Small-scale

0.479

High

165966

TCPB
T-complex protein 1 subunit beta

1

5

Small-scale

0.479

High

165967

CLH1
Clathrin heavy chain 1

1

1

Small-scale

0.479

High

165970

K1C17
Keratin, type I cytoskeletal 17

1

1

Small-scale

0.479

High

165971

CKAP4
Cytoskeleton-associated protein 4

1

13

Small-scale

0.479

High

165973

AHNK
Neuroblast differentiation-associated protein AHNAK

1

1

Small-scale

0.479

High

165975

ACACA
Acetyl-CoA carboxylase 1

1

4

Small-scale

0.479

High

165978

FLNC
Filamin-C

1

5

Small-scale

0.479

High

165979

IMB1
Importin subunit beta-1

1

3

Small-scale

0.479

High

165982

PDIA6
Protein disulfide-isomerase A6

1

2

Small-scale

0.479

High

165983

KPCD1
Serine/threonine-protein kinase D1

1

8

Small-scale

0.479

High

165984

PLEC
Plectin

1

3

Small-scale

0.479

High

165985

SEPT7
Septin-7

1

2

Small-scale

0.479

High

165995

MYH14
Myosin-14

1

9

Small-scale

0.479

High

166006

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

4

Small-scale

0.479

High

166007

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

Small-scale

0.479

High

166009

TCPH
T-complex protein 1 subunit eta

1

3

Small-scale

0.479

High

166012

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

3

Small-scale

0.479

High

166017

RALY
RNA-binding protein Raly

1

1

Small-scale

0.479

High

166021

TLN1
Talin-1

1

4

Small-scale

0.479

High

165920

TCTP
Translationally-controlled tumor protein

1

0

Small-scale

0.460

High

165892

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

Small-scale

0.458

High

165894

CISY
Citrate synthase, mitochondrial

1

0

Small-scale

0.458

High

165899

K2C6A
Keratin, type II cytoskeletal 6A

1

0

Small-scale

0.458

High

165901

TFR1
Transferrin receptor protein 1

1

0

Small-scale

0.458

High

165902

ALDOA
Fructose-bisphosphate aldolase A

1

0

Small-scale

0.458

High

165909

ENOA
Alpha-enolase

1

0

Small-scale

0.458

High

165910

G6PI
Glucose-6-phosphate isomerase

1

0

Small-scale

0.458

High

165915

G6PD
Glucose-6-phosphate 1-dehydrogenase

1

0

Small-scale

0.458

High

165929

VDAC1
Voltage-dependent anion-selective channel protein 1

1

0

Small-scale

0.458

High

165930

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

Small-scale

0.458

High

165940

RS19
Small ribosomal subunit protein eS19

1

0

Small-scale

0.458

High

165948

CAPZB
F-actin-capping protein subunit beta

1

0

Small-scale

0.458

High

165961

1433E
14-3-3 protein epsilon

1

0

Small-scale

0.458

High

165963

RL39
Large ribosomal subunit protein eL39

1

0

Small-scale

0.458

High

165998

HID1
Protein HID1

1

0

Small-scale

0.458

High

166014

AKIP
Small ribosomal subunit protein mS38

1

0

Small-scale

0.458

High

166020

RL36
Large ribosomal subunit protein eL36

1

0

Small-scale

0.458

High

166015

DEC1
Deleted in esophageal cancer 1

1

4

High-throughput

0.439

High

165959

RAB5B
Ras-related protein Rab-5B

1

1

Small-scale

0.437

High

165997

CPNE8
Copine-8

1

2

Small-scale

0.437

High

165999

CPNE9
Copine-9

1

2

Small-scale

0.437

High

86495

WASH3
Putative WAS protein family homolog 3

1

0

High-throughput

0.426

High

165991

WAC2A
WASH complex subunit 2A

1

0

High-throughput

0.426

High

166019

WASC3
WASH complex subunit 3

1

0

High-throughput

0.279

Low

62839

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

0

Small-scale

0.249

Low

165941

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

Small-scale

0.249

Low

165944

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

Small-scale

0.249

Low

166002

TNR14
Tumor necrosis factor receptor superfamily member 14

1

0

High-throughput

0.249

Low

166003

ERO1A
ERO1-like protein alpha

1

0

Small-scale

0.249

Low

166013

APMAP
Adipocyte plasma membrane-associated protein

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024