Protein: TMOD1
Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod)

Gene: TMOD1
Organism: Homo sapiens
Interactions: 162
UniProt ID: P28289

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005523 - tropomyosin binding
GO:0005829 - cytosol
GO:0005856 - cytoskeleton
GO:0005865 - striated muscle thin filament

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

701975

FLII
Protein flightless-1 homolog

5

14

High-throughput

0.919

High

442240

GELS
Gelsolin

4

13

High-throughput

0.892

High

702069

SCIN
Scinderin

4

13

High-throughput

0.892

High

701965

ACTB
Actin, cytoplasmic 1

2

14

High-throughput

0.789

High

336354

SVIL
Supervillin

2

13

High-throughput

0.737

High

701992

LRRF1
Leucine-rich repeat flightless-interacting protein 1

5

7

High-throughput

0.712

High

702046

MYO5C
Unconventional myosin-Vc

4

7

High-throughput

0.699

High

701969

ACTG
Actin, cytoplasmic 2

1

13

High-throughput

0.691

High

702058

MYO5B
Unconventional myosin-Vb

4

8

High-throughput

0.691

High

247085

TBCD4
TBC1 domain family member 4

3

1

High-throughput

0.667

High

701977

SNX1
Sorting nexin-1

3

3

High-throughput

0.667

High

701990

DREB
Drebrin

3

2

High-throughput

0.662

High

702068

LRRF2
Leucine-rich repeat flightless-interacting protein 2

5

12

High-throughput

0.650

High

123598

MYO1C
Unconventional myosin-Ic

2

14

High-throughput

0.628

High

702063

CBPC1
Cytosolic carboxypeptidase 1

3

0

High-throughput

0.622

High

447682

TPM3
Tropomyosin alpha-3 chain

1

6

High-throughput

0.618

High

482837

TPM1
Tropomyosin alpha-1 chain

1

6

High-throughput

0.618

High

701967

ACTA
Actin, aortic smooth muscle

1

13

High-throughput

0.618

High

701970

TPM4
Tropomyosin alpha-4 chain

1

6

High-throughput

0.618

High

702045

ANLN
Anillin

2

3

High-throughput

0.611

High

702014

NIN
Ninein

3

8

High-throughput

0.609

High

177364

ARHGB
Rho guanine nucleotide exchange factor 11

2

9

High-throughput

0.571

High

224088

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

1

3

High-throughput

0.541

High

252327

TLR2
Toll-like receptor 2

1

1

High-throughput

0.541

High

555889

CADH1
Cadherin-1

1

2

High-throughput

0.541

High

668510

APC
Adenomatous polyposis coli protein

1

1

High-throughput

0.541

High

702027

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.541

High

702035

RHG07
Rho GTPase-activating protein 7

1

3

High-throughput

0.541

High

227806

MYO1B
Unconventional myosin-Ib

1

14

High-throughput

0.536

High

637357

FLNA
Filamin-A

1

4

High-throughput

0.536

High

667549

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.536

High

701949

LSP1
Lymphocyte-specific protein 1

1

1

High-throughput

0.536

High

701951

MYH9
Myosin-9

1

1

High-throughput

0.536

High

701952

ADDA
Alpha-adducin

1

1

High-throughput

0.536

High

701957

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

5

High-throughput

0.536

High

701958

CAZA2
F-actin-capping protein subunit alpha-2

1

4

High-throughput

0.536

High

701959

CAPZB
F-actin-capping protein subunit beta

1

4

High-throughput

0.536

High

701966

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

5

High-throughput

0.536

High

701973

CALD1
Caldesmon

1

13

High-throughput

0.536

High

701993

PKHG6
Pleckstrin homology domain-containing family G member 6

1

11

High-throughput

0.536

High

702007

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.536

High

702012

ABRA
Actin-binding Rho-activating protein

1

2

High-throughput

0.536

High

702013

SYNPO
Synaptopodin

1

2

High-throughput

0.536

High

702024

MY18A
Unconventional myosin-XVIIIa

1

7

High-throughput

0.536

High

702030

ZMY19
Zinc finger MYND domain-containing protein 19

1

1

High-throughput

0.536

High

702032

MYO19
Unconventional myosin-XIX

1

9

High-throughput

0.536

High

702047

PDLI7
PDZ and LIM domain protein 7

1

2

High-throughput

0.536

High

702054

LIMA1
LIM domain and actin-binding protein 1

1

2

High-throughput

0.536

High

701974

NEXN
Nexilin

2

1

High-throughput

0.521

High

549947

DCOR
Ornithine decarboxylase

1

0

High-throughput

0.518

High

701954

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

0

High-throughput

0.518

High

701956

DCC
Netrin receptor DCC

1

0

High-throughput

0.518

High

561109

GILT
Gamma-interferon-inducible lysosomal thiol reductase

1

0

High-throughput

0.513

High

611773

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

647425

SCP2
Sterol carrier protein 2

1

0

High-throughput

0.513

High

701953

PSB10
Proteasome subunit beta type-10

1

0

High-throughput

0.513

High

701961

CACB3
Voltage-dependent L-type calcium channel subunit beta-3

1

0

High-throughput

0.513

High

701980

PDE7A
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A

1

0

High-throughput

0.513

High

701981

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.513

High

701988

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

701989

SMAD2
Mothers against decapentaplegic homolog 2

1

0

High-throughput

0.513

High

701991

SAMTR
S-adenosylmethionine sensor upstream of mTORC1

1

0

High-throughput

0.513

High

701998

RRAGB
Ras-related GTP-binding protein B

1

0

High-throughput

0.513

High

702031

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.513

High

702049

PNO1
RNA-binding protein PNO1

1

0

High-throughput

0.513

High

635495

NEBU
Nebulin

1

3

Small-scale

0.501

High

701960

DAPK1
Death-associated protein kinase 1

1

4

High-throughput

0.489

High

701983

HLX
H2.0-like homeobox protein

1

1

High-throughput

0.489

High

702002

RSLBA
Ras-like protein family member 11A

1

1

High-throughput

0.489

High

702015

S2541
Mitochondrial carrier protein SCaMC-3L

1

2

High-throughput

0.489

High

702034

BIRC8
Baculoviral IAP repeat-containing protein 8

1

6

High-throughput

0.489

High

702037

GA2L1
GAS2-like protein 1

1

1

High-throughput

0.489

High

702041

LPAR2
Lysophosphatidic acid receptor 2

1

1

High-throughput

0.489

High

702044

C1QR1
Complement component C1q receptor

1

3

High-throughput

0.489

High

702052

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

1

High-throughput

0.489

High

701955

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

4

High-throughput

0.481

High

701963

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

2

Small-scale

0.481

High

137979

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

3

High-throughput

0.479

High

159154

ABLM1
Actin-binding LIM protein 1

1

1

High-throughput

0.479

High

228550

STRN
Striatin

1

4

High-throughput

0.479

High

281004

TACC1
Transforming acidic coiled-coil-containing protein 1

1

1

High-throughput

0.479

High

315160

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

324092

CE152
Centrosomal protein of 152 kDa

1

2

High-throughput

0.479

High

340088

PCNT
Pericentrin

1

9

High-throughput

0.479

High

584480

VAV
Proto-oncogene vav

1

10

High-throughput

0.479

High

701962

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

High-throughput

0.479

High

701968

H4
Histone H4

1

1

High-throughput

0.479

High

701976

GOGA4
Golgin subfamily A member 4

1

7

High-throughput

0.479

High

701978

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

6

High-throughput

0.479

High

701982

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

1

High-throughput

0.479

High

701984

GOGB1
Golgin subfamily B member 1

1

7

High-throughput

0.479

High

701985

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

2

High-throughput

0.479

High

701986

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.479

High

701994

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

4

High-throughput

0.479

High

701995

RHG21
Rho GTPase-activating protein 21

1

2

High-throughput

0.479

High

701997

ECM29
Proteasome adapter and scaffold protein ECM29

1

1

High-throughput

0.479

High

702003

MPRIP
Myosin phosphatase Rho-interacting protein

1

5

High-throughput

0.479

High

702005

CRACD
Capping protein-inhibiting regulator of actin dynamics

1

7

High-throughput

0.479

High

702010

GCC2
GRIP and coiled-coil domain-containing protein 2

1

5

High-throughput

0.479

High

702016

ARFG2
ADP-ribosylation factor GTPase-activating protein 2

1

4

High-throughput

0.479

High

702020

LMO7
LIM domain only protein 7

1

4

High-throughput

0.479

High

702021

ASB11
Ankyrin repeat and SOCS box protein 11

1

6

High-throughput

0.479

High

702023

TSC1
Hamartin

1

11

High-throughput

0.479

High

702036

NEB2
Neurabin-2

1

3

High-throughput

0.479

High

702043

CPAP
Centrosomal P4.1-associated protein

1

4

High-throughput

0.479

High

702051

RNF12
E3 ubiquitin-protein ligase RLIM

1

2

High-throughput

0.479

High

702059

CLC4E
C-type lectin domain family 4 member E

1

4

High-throughput

0.479

High

702061

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

4

High-throughput

0.479

High

702062

CP131
Centrosomal protein of 131 kDa

1

3

High-throughput

0.479

High

702066

WIPI4
WD repeat domain phosphoinositide-interacting protein 4

1

3

High-throughput

0.479

High

213073

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.458

High

215258

TXNL1
Thioredoxin-like protein 1

1

0

High-throughput

0.458

High

289931

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

400326

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

538883

EPB41
Protein 4.1

1

0

High-throughput

0.458

High

702011

S35F2
Solute carrier family 35 member F2

1

0

Small-scale

0.458

High

702038

HAUS8
HAUS augmin-like complex subunit 8

1

0

High-throughput

0.458

High

51043

PKHG3
Pleckstrin homology domain-containing family G member 3

1

11

High-throughput

0.445

High

387101

TNNC2
Troponin C, skeletal muscle

1

1

High-throughput

0.445

High

701950

BMI1
Polycomb complex protein BMI-1

1

4

High-throughput

0.445

High

701964

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

4

High-throughput

0.445

High

701987

CNN3
Calponin-3

1

5

High-throughput

0.445

High

702000

PKHA7
Pleckstrin homology domain-containing family A member 7

1

3

High-throughput

0.445

High

702006

SSH2
Protein phosphatase Slingshot homolog 2

1

5

High-throughput

0.445

High

702022

SSH1
Protein phosphatase Slingshot homolog 1

1

5

High-throughput

0.445

High

702026

CSN5
COP9 signalosome complex subunit 5

1

3

Small-scale

0.445

High

702028

Q96D37
VAV1 protein

1

10

High-throughput

0.445

High

702060

MYO6
Unconventional myosin-VI

1

10

High-throughput

0.445

High

702064

COR2B
Coronin-2B

1

7

High-throughput

0.445

High

702017

ARF
Tumor suppressor ARF

1

0

High-throughput

0.438

High

105394

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

230505

KIF1C
Kinesin-like protein KIF1C

1

3

High-throughput

0.437

High

293249

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.437

High

371235

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.437

High

411409

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

701972

VIGLN
Vigilin

1

3

High-throughput

0.437

High

701996

CCD18
Coiled-coil domain-containing protein 18

1

8

High-throughput

0.437

High

701999

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

5

High-throughput

0.437

High

702008

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

8

High-throughput

0.437

High

702009

LRC49
Leucine-rich repeat-containing protein 49

1

1

High-throughput

0.437

High

702018

DLG5
Disks large homolog 5

1

1

High-throughput

0.437

High

702048

STRN4
Striatin-4

1

3

High-throughput

0.437

High

702067

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.437

High

254824

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.407

High

702019

S38A5
Sodium-coupled neutral amino acid transporter 5

1

1

High-throughput

0.407

High

702025

COR2A
Coronin-2A

1

5

High-throughput

0.407

High

702056

SH3L2
SH3 domain-binding glutamic acid-rich-like protein 2

1

1

High-throughput

0.407

High

702055

MLH3
DNA mismatch repair protein Mlh3

1

0

High-throughput

0.282

High

431519

AP2A
Transcription factor AP-2-alpha

1

0

High-throughput

0.279

Low

701971

RT05
Small ribosomal subunit protein uS5m

1

0

High-throughput

0.279

Low

702001

KLH10
Kelch-like protein 10

1

0

High-throughput

0.279

Low

702029

ERLEC
Endoplasmic reticulum lectin 1

1

0

High-throughput

0.279

Low

702039

ASHWN
Ashwin

1

0

High-throughput

0.279

Low

702042

PROK2
Prokineticin-2

1

0

High-throughput

0.279

Low

702050

GKN1
Gastrokine-1

1

0

High-throughput

0.279

Low

702053

FXL17
F-box/LRR-repeat protein 17

1

0

Small-scale

0.251

Low

701979

TBB2A
Tubulin beta-2A chain

1

0

High-throughput

0.249

Low

702004

TPGS1
Tubulin polyglutamylase complex subunit 1

1

0

High-throughput

0.249

Low

702033

CC138
Coiled-coil domain-containing protein 138

1

0

High-throughput

0.249

Low

702040

K1671
Uncharacterized protein KIAA1671

1

0

High-throughput

0.249

Low

702057

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

702065

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025