HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: AP1M1 (Q9BXS5)
AP-1 complex subunit mu-1 (AP-mu chain family member mu1A) (Adaptor protein complex AP-1 subunit mu-1) (Adaptor-related protein complex 1 subunit mu-1) (Clathrin assembly protein complex 1 mu-1 medium chain 1) (Clathrin coat assembly protein AP47) (Clathrin coat-associated protein AP47) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Mu-adaptin 1) (Mu1A-adaptin)
Gene: AP1M1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 423
+	Hs
		228309 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AP2M1_HUMAN (3-421): 3.27e-155: 447: 38.85
+	Hs
		229113 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AP3M1_HUMAN (3-422): 5.32e-127: 375: 26.73
+	Hs
		226952 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AP3M2_HUMAN (3-422): 2.67e-123: 365: 25.81
+	Hs
		119697 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AP4M1_HUMAN (3-422): 3.59e-119: 356: 25.83
+	Hs
		1168532 RN19B_HUMAN (220-460): 6.9e-59: 207: 19.18		AP1M1_HUMAN (1-423): 0: 528: 100.00
+	Hs
		476314 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AP1M1_HUMAN (1-423): 0: 528: 100.00
+	At
		187127 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		AP1M2_ARATH (2-422): 1.25e-171: 488: 60.47
+	Hs
		1168543 RN19B_HUMAN (220-460): 6.9e-59: 207: 19.18		AP3M1_HUMAN (3-422): 5.32e-127: 375: 26.73
+	Hs
		476177 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AP2M1_HUMAN (3-421): 3.27e-155: 447: 38.85
+	Hs
		226813 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		COPD_HUMAN (8-165): 1.23e-18: 89.7: 17.72
+	Hs
		476116 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		STON2_HUMAN (125-422): 2.26e-71: 243: 21.85
+	At
		1091884 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		COPD_ARATH (1-178): 6.67e-35: 137: 17.98
+	Hs
		475474 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		COPD_HUMAN (8-165): 1.23e-18: 89.7: 17.72