HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: UN45A (Q9H3U1)
Protein unc-45 homolog A (Unc-45A) (GCUNC-45) (Smooth muscle cell-associated protein 1) (SMAP-1)
Gene: UNC45A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0016607 - nuclear speck GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 944
+	Hs
		226943 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PPP5_HUMAN (10-180): 3.77e-39: 154: 23.98
+	Hs
		229059 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CHIP_HUMAN (8-159): 1.54e-35: 139: 29.30
+	Hs
		174471 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		OGT1_HUMAN (3-192): 2.53e-24: 112: 12.63
+	Hs
		226646 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		STIP1_HUMAN (4-228): 9.18e-17: 86.8: 15.32
+	Hs
		226108 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TOM70_HUMAN (12-220): 4.6e-09: 62.2: 13.08
+	Dm
		1180619 PRKN_DROME (1-463): 3.5e-106: 325: 42.19		Q7KJA9_DROME (48-469): 9.79e-18: 90.7: 11.87
+	Dm
		1214030 LUBEL_DROME (55-453): 1.14e-66: 234: 16.95		Q9VH81_DROME (6-180): 1.39e-38: 153: 22.29
+	Hs
		1078489 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		TOM34_HUMAN (2-139): 4.73e-31: 126: 27.54
+	Hs
		174509 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		OGT1_HUMAN (3-192): 2.53e-24: 112: 12.63
+	Dm
		284375 ARI2_DROME (228-464): 7.29e-69: 229: 20.92		Q7KJA9_DROME (48-469): 9.79e-18: 90.7: 11.87
+	Hs
		475516 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TTC3_HUMAN (7-436): 6.41e-44: 175: 13.17
+	Hs
		1317095 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		FKBPL_HUMAN (25-135): 1.26e-11: 69.3: 37.93
+	Hs
		213459 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SGTA_HUMAN (1-141): 4.45e-39: 149: 27.66
+	Hs
		476568 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		CHIP_HUMAN (8-159): 1.54e-35: 139: 29.30
+	Hs
		475662 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SPAG1_HUMAN (16-201): 1.08e-25: 116: 22.61
+	Pf
		1181548 Q7KQK2_PLAF7 (1-76): 8.17e-31: 124: 28.95		HSOP_PLAF7 (22-305): 4.91e-25: 112: 12.67
+	Hs
		174570 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		OGT1_HUMAN (3-192): 2.53e-24: 112: 12.63
+	Hs
		476533 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		FKBPL_HUMAN (25-135): 1.26e-11: 69.3: 37.93