HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: TBK1 (Q9UHD2)
Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)
Gene: TBK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	29903906, 35509820
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010629 - negative regulation of gene expression GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 729
+	Hs
		167425 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		IKKA_HUMAN (9-637): 4.09e-121: 381: 21.08
+	Hs
		226028 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ROCK2_HUMAN (7-724): 1.1e-114: 378: 16.52
+	Hs
		228139 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MK15_HUMAN (1-419): 3.82e-116: 362: 17.51
+	Hs
		226557 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CDK2_HUMAN (6-312): 1.71e-119: 361: 20.97
+	Hs
		475222 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		TBK1_HUMAN (1-729): 0: 564: 100.00
+	Hs
		226582 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MARK3_HUMAN (9-267): 1.86e-85: 287: 28.08
+	Hs
		476524 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		TBK1_HUMAN (1-729): 0: 564: 100.00
+	Mm
		841459 RN19A_MOUSE (236-452): 2.59e-30: 126: 21.62		TBK1_MOUSE (1-729): 0: 558: 94.10
+	Mm
		291482 HOIL1_MOUSE (12-448): 2.29e-67: 225: 17.50		IKKB_MOUSE (9-708): 1.02e-140: 433: 19.60
+	Mm
		1141262 HOIL1_MOUSE (12-448): 2.29e-67: 225: 17.50		IKKA_MOUSE (9-637): 1.7e-120: 379: 20.94
+	Hs
		475745 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		IKKE_HUMAN (1-716): 4.07e-146: 445: 48.33
+	Hs
		158377 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		IKKB_HUMAN (9-727): 1.01e-139: 430: 18.98
+	Hs
		228013 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ULK2_HUMAN (13-222): 2.85e-25: 114: 33.80
+	Hs
		167451 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		IKKA_HUMAN (9-637): 4.09e-121: 381: 21.08
+	At
		1091646 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		MPK4_ARATH (12-351): 8.93e-120: 365: 16.76
+	At
		1091641 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		KIN10_ARATH (8-395): 3.62e-117: 363: 20.05
+	Sc
		605977 HEL1_YEAST (204-463): 2e-41: 156: 19.78		RAD53_YEAST (10-221): 1.29e-22: 105: 31.65
+	Hs
		262227 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ULK1_HUMAN (13-222): 2.86e-26: 117: 34.10
+	At
		98421 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		RUK_ARATH (13-221): 2.64e-22: 105: 33.18