HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: SNCAP (Q9Y6H5)
Synphilin-1 (Sph1) (Alpha-synuclein-interacting protein)
Gene: SNCAIP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.752

Property	Details
Experiments	11590439, 16049031, 15603737, 16096643, 15944382, 20089136, 21590270, 15894486, 32814053
Identification Methods	affinity chromatography technology, enzymatic study, two hybrid, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0042417 - dopamine metabolic process
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 919
+	Hs
		1377914 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		SNCAP_HUMAN (1-919): 0: 553: 100.00
+	Hs
		1346318 RN19A_HUMAN (236-452): 6.6e-31: 128: 21.62		SNCAP_HUMAN (1-919): 0: 553: 100.00
+	Hs
		227985 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ANKH1_HUMAN (3-865): 3.17e-65: 242: 12.01
+	Hs
		227310 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ANK3_HUMAN (356-833): 6.59e-51: 197: 13.26
+	Hs
		474885 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		POTEJ_HUMAN (318-892): 1.19e-80: 284: 16.26
+	Hs
		226081 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSD10_HUMAN (324-540): 1.21e-36: 139: 22.37
+	Hs
		228609 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		UACA_HUMAN (207-439): 3.69e-18: 92.3: 12.03
+	Hs
		229176 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ASB3_HUMAN (418-541): 9.11e-15: 80.2: 23.66
+	Xl
		1151527 Q7SY79_XENLA (1-149): 2.25e-49: 179: 19.33		MIB1_XENLA (321-736): 1.49e-48: 189: 12.21
+	Hs
		476024 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ANKH1_HUMAN (3-865): 3.17e-65: 242: 12.01
+	Hs
		476011 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		MIB1_HUMAN (309-736): 2.35e-48: 188: 11.82
+	Hs
		312683 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		ASB3_HUMAN (418-541): 9.11e-15: 80.2: 23.66
+	Hs
		475511 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		DAPK1_HUMAN (212-439): 1.26e-36: 151: 17.60
+	Hs
		276134 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSD10_HUMAN (324-540): 1.21e-36: 139: 22.37
+	Hs
		475980 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ANS1B_HUMAN (220-389): 8.43e-18: 91.1: 9.33
+	Hs
		476634 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		ASB3_HUMAN (418-541): 9.11e-15: 80.2: 23.66