Protein: AGRL1
Adhesion G protein-coupled receptor L1 (Calcium-independent alpha-latrotoxin receptor 1) (CIRL-1) (Latrophilin-1) (Lectomedin-2)

Gene: AGRL1, ADGRL1
Organism: Homo sapiens
Interactions: 77
UniProt ID: O94910

Gene Ontology (top 5):
GO:0004930 - G protein-coupled receptor activity
GO:0005886 - plasma membrane
GO:0007166 - cell surface receptor signaling pathway
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0007189 - adenylate cyclase-activating G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

321792

VSIG4
V-set and immunoglobulin domain-containing protein 4

4

2

High-throughput

0.892

High

321760

NRG1
Pro-neuregulin-1, membrane-bound isoform

3

1

High-throughput

0.861

High

321789

FLRT1
Leucine-rich repeat transmembrane protein FLRT1

2

13

High-throughput

0.811

High

321739

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

4

High-throughput

0.691

High

321740

GPIX
Platelet glycoprotein IX

1

17

High-throughput

0.691

High

321751

EVA1C
Protein eva-1 homolog C

1

1

High-throughput

0.691

High

321763

EREP1
Endosomal transmembrane epsin interactor 1

3

1

High-throughput

0.667

High

260817

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.656

High

321765

CC50B
Cell cycle control protein 50B

2

3

High-throughput

0.628

High

321779

GPR21
Probable G-protein coupled receptor 21

2

5

High-throughput

0.628

High

321790

CLC2D
C-type lectin domain family 2 member D

2

10

High-throughput

0.628

High

321791

PCDAC
Protocadherin alpha-12

2

7

High-throughput

0.628

High

321794

PCDGD
Protocadherin gamma-B1

2

10

High-throughput

0.628

High

321746

CD1B
T-cell surface glycoprotein CD1b

1

5

High-throughput

0.618

High

229858

EDIL3
EGF-like repeat and discoidin I-like domain-containing protein 3

3

4

High-throughput

0.609

High

321731

VNN2
Pantetheine hydrolase VNN2

2

0

High-throughput

0.602

High

321732

TSN15
Tetraspanin-15

2

14

High-throughput

0.601

High

219263

B4GA1
Beta-1,4-glucuronyltransferase 1

2

2

High-throughput

0.574

High

139671

CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

1

8

High-throughput

0.573

High

321743

APC
Adenomatous polyposis coli protein

1

1

High-throughput

0.541

High

321782

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

6

High-throughput

0.541

High

132544

UPK1A
Uroplakin-1a

1

17

High-throughput

0.536

High

139163

UPK2
Uroplakin-2

1

6

High-throughput

0.536

High

321742

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

4

High-throughput

0.536

High

321744

EDNRA
Endothelin-1 receptor

1

8

High-throughput

0.536

High

321748

SCN4A
Sodium channel protein type 4 subunit alpha

1

8

High-throughput

0.536

High

321758

EREP3
Protein ENTREP3

1

1

High-throughput

0.536

High

321761

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

11

High-throughput

0.536

High

321767

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

4

High-throughput

0.536

High

321771

TM11B
Transmembrane protease serine 11B

1

3

High-throughput

0.536

High

321773

TM130
Transmembrane protein 130

1

1

High-throughput

0.536

High

321783

TTYH1
Protein tweety homolog 1

1

2

High-throughput

0.536

High

284366

CLN5
Bis(monoacylglycero)phosphate synthase CLN5

1

0

High-throughput

0.513

High

321734

IL2RA
Interleukin-2 receptor subunit alpha

1

0

High-throughput

0.513

High

321754

VA0D1
V-type proton ATPase subunit d 1

1

0

High-throughput

0.513

High

321766

NKAI1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

1

0

High-throughput

0.513

High

321769

PCAT2
Lysophosphatidylcholine acyltransferase 2

1

0

High-throughput

0.513

High

321772

LSME2
Leucine-rich single-pass membrane protein 2

1

0

High-throughput

0.513

High

321781

TMM59
Transmembrane protein 59

1

0

High-throughput

0.513

High

321786

NRN1
Neuritin

1

0

High-throughput

0.513

High

321777

ZDH12
Palmitoyltransferase ZDHHC12

1

2

High-throughput

0.489

High

321793

TMED7
Transmembrane emp24 domain-containing protein 7

1

2

High-throughput

0.489

High

126411

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

321733

RASK
GTPase KRas

1

9

High-throughput

0.479

High

321735

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

14

High-throughput

0.479

High

321736

LYN
Tyrosine-protein kinase Lyn

1

7

High-throughput

0.479

High

321737

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

321738

HS90B
Heat shock protein HSP 90-beta

1

1

High-throughput

0.479

High

321741

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

321747

EPHA2
Ephrin type-A receptor 2

1

8

High-throughput

0.479

High

321749

BASI
Basigin

1

5

High-throughput

0.479

High

321752

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

321753

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

321755

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

321756

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

321757

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

321759

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

321784

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

321785

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

321788

CC50A
Cell cycle control protein 50A

1

3

High-throughput

0.479

High

254690

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

4

High-throughput

0.445

High

321750

OR1D4
Olfactory receptor 1D4

1

3

High-throughput

0.445

High

321762

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

8

High-throughput

0.445

High

321780

ZNT2
Proton-coupled zinc antiporter SLC30A2

1

7

High-throughput

0.445

High

321745

PSA3
Proteasome subunit alpha type-3

1

1

High-throughput

0.439

High

104997

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

321730

KI20A
Kinesin-like protein KIF20A

1

4

High-throughput

0.437

High

321778

SNX27
Sorting nexin-27

1

14

High-throughput

0.437

High

321764

SC5A9
Sodium/glucose cotransporter 4

1

0

High-throughput

0.426

High

321787

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.417

High

170593

CLGN
Calmegin

1

10

High-throughput

0.407

High

321775

TBC15
TBC1 domain family member 15

1

1

High-throughput

0.407

High

321776

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

0

High-throughput

0.328

High

124178

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.279

Low

321768

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.279

Low

321770

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

1

0

High-throughput

0.232

Low

321774

SPX3
Sugar phosphate exchanger 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025