HitPredict

Interactor 1: SMCA5 (O60264)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H)
Gene: SMARCA5

Interactor 2: CENPA (P49450)
Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)
Gene: CENPA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	34079125, 15009096
Identification Methods	proximity labelling technology, biochemical
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005721 - pericentric heterochromatin
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1052 Hs			1 140
+	Hs
		229359 SMCA5_HUMAN (19-1052): 0: 1097: 100.00		H31_HUMAN (5-134): 1.29e-52: 164: 48.86
+	Hs
		229363 SMCA5_HUMAN (19-1052): 0: 1097: 100.00		H33_HUMAN (5-134): 1.57e-51: 161: 49.62
+	Mm
		935460 SMCA5_MOUSE (33-1052): 0: 1094: 98.33		H31_MOUSE (5-134): 1.29e-52: 164: 48.86
+	Mm
		952266 SMCA5_MOUSE (33-1052): 0: 1094: 98.33		H32_MOUSE (5-134): 1.73e-51: 161: 48.86
+	Mm
		952763 SMCA5_MOUSE (33-1052): 0: 1094: 98.33		H33_MOUSE (5-134): 1.57e-51: 161: 49.62
+	Hs
		658641 SMCA1_HUMAN (71-1030): 0: 1042: 85.29		CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00
+	Hs
		658647 SMCA1_HUMAN (71-1030): 0: 1042: 85.29		H31_HUMAN (5-134): 1.29e-52: 164: 48.86
+	Hs
		658651 SMCA1_HUMAN (71-1030): 0: 1042: 85.29		H33_HUMAN (5-134): 1.57e-51: 161: 49.62
+	Sc
		902117 ISW2_YEAST (1-1052): 0: 848: 45.67		H3_YEAST (5-134): 5.26e-46: 147: 46.57
+	Hs
		935016 CHD5_HUMAN (5-1050): 0: 809: 26.28		H31_HUMAN (5-134): 1.29e-52: 164: 48.86
+	Hs
		828213 CHD3_HUMAN (8-1052): 0: 801: 26.23		CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00
+	Hs
		1086233 CHD5_HUMAN (5-1050): 0: 809: 26.28		H31T_HUMAN (5-134): 1.01e-51: 162: 48.09
+	Mm
		56901 CHD5_MOUSE (5-1050): 0: 810: 26.45		H33_MOUSE (5-134): 1.57e-51: 161: 49.62
+	Hs
		828410 CHD7_HUMAN (9-1049): 0: 800: 25.86		CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00
+	Hs
		934705 CHD3_HUMAN (8-1052): 0: 801: 26.23		H31_HUMAN (5-134): 1.29e-52: 164: 48.86
+	Hs
		935324 CHD7_HUMAN (9-1049): 0: 800: 25.86		H31_HUMAN (5-134): 1.29e-52: 164: 48.86
+	Hs
		952302 CHD3_HUMAN (8-1052): 0: 801: 26.23		H33_HUMAN (5-134): 1.57e-51: 161: 49.62
+	Hs
		952670 CHD7_HUMAN (9-1049): 0: 800: 25.86		H33_HUMAN (5-134): 1.57e-51: 161: 49.62
+	Sc
		744893 ISW1_YEAST (2-1046): 0: 790: 43.78		H3_YEAST (5-134): 5.26e-46: 147: 46.57
+	Hs
		934770 CHD4_HUMAN (14-945): 0: 769: 26.95		H31_HUMAN (5-134): 1.29e-52: 164: 48.86