HitPredict

Interactor 1: SI1L3 (O60292)
Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3)
Gene: SIPA1L3

Interactor 2: LZTS2 (Q9BRK4)
Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)
Gene: LZTS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	28514442, 29395067, 33961781
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1781 Hs			1 669
+	Hs
		1310197 SI1L2_HUMAN (1-1774): 0: 1393: 43.94		LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00
+	Hs
		1350316 SI1L2_HUMAN (1-1774): 0: 1393: 43.94		LZTS1_HUMAN (26-653): 2.54e-34: 140: 35.06
+	Hs
		165788 SI1L2_HUMAN (1-1774): 0: 1393: 43.94		N4BP3_HUMAN (17-640): 5.23e-34: 139: 27.16
+	Hs
		230555 SI1L2_HUMAN (1-1774): 0: 1393: 43.94		LZTS3_HUMAN (1-669): 7.26e-32: 133: 31.62
+	Hs
		230186 SI1L3_HUMAN (1-1781): 0: 1374: 100.00		LZTS3_HUMAN (1-669): 7.26e-32: 133: 31.62
+	Hs
		1145965 SI1L2_HUMAN (1-1774): 0: 1393: 43.94		CP135_HUMAN (300-610): 1.6e-09: 63.5: 21.52
+	Hs
		230265 SI1L3_HUMAN (1-1781): 0: 1374: 100.00		MY18A_HUMAN (329-637): 1.72e-11: 70: 17.67
+	Hs
		230253 SI1L3_HUMAN (1-1781): 0: 1374: 100.00		CP135_HUMAN (300-610): 1.6e-09: 63.5: 21.52
+	Hs
		196501 SI1L1_HUMAN (3-1774): 0: 1211: 45.79		LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00
+	Hs
		196381 SI1L1_HUMAN (3-1774): 0: 1211: 45.79		LZTS3_HUMAN (1-669): 7.26e-32: 133: 31.62
+	Hs
		196455 SI1L1_HUMAN (3-1774): 0: 1211: 45.79		CP135_HUMAN (300-610): 1.6e-09: 63.5: 21.52
+	Mm
		1142070 TSC2_MOUSE (227-876): 4.12e-154: 520: 15.87		TSC1_MOUSE (48-630): 3.36e-32: 135: 13.67
+	Rn
		835139 TSC2_RAT (227-876): 1.06e-156: 528: 16.00		TSC1_RAT (48-630): 5.02e-27: 119: 13.44
+	Hs
		148885 RGPA2_HUMAN (361-868): 3.58e-125: 437: 17.93		CTRO_HUMAN (327-578): 7.02e-09: 61.3: 16.36
+	Hs
		1061846 RGPA1_HUMAN (327-850): 4.76e-106: 379: 18.68		SLMAP_HUMAN (328-641): 1.08e-09: 63.9: 19.94
+	Mm
		1112023 Q3TQ10_MOUSE (655-876): 6.62e-81: 268: 20.00		TSC1_MOUSE (48-630): 3.36e-32: 135: 13.67
+	Hs
		1310230 MAST1_HUMAN (986-1524): 1.08e-41: 171: 14.29		LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00
+	Hs
		1291406 SIPA1_HUMAN (1448-1781): 4.85e-14: 80.2: 19.42		LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00
+	Hs
		148818 MDC1_HUMAN (1120-1713): 5.36e-10: 67: 13.41		CTRO_HUMAN (327-578): 7.02e-09: 61.3: 16.36
+	Hs
		1145855 DLG5_HUMAN (1042-1430): 3.08e-09: 64.4: 9.23		CP135_HUMAN (300-610): 1.6e-09: 63.5: 21.52