Protein: DDIT3
DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA damage-inducible protein GADD153)

Gene: DDIT3
Organism: Homo sapiens
Interactions: 126
UniProt ID: P35638

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

617129

ATF3
Cyclic AMP-dependent transcription factor ATF-3

10

15

Small-scale

0.759

High

775406

CEBPG
CCAAT/enhancer-binding protein gamma

7

16

Small-scale

0.751

High

606334

CEBPB
CCAAT/enhancer-binding protein beta

8

14

Small-scale

0.749

High

370590

FOS
Protein c-Fos

7

16

Small-scale

0.744

High

775475

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

6

14

High-throughput

0.735

High

584071

FOSL2
Fos-related antigen 2

5

14

High-throughput

0.725

High

775426

BATF
Basic leucine zipper transcriptional factor ATF-like

5

12

Small-scale

0.721

High

775401

CEBPA
CCAAT/enhancer-binding protein alpha

4

11

Small-scale

0.701

High

775466

DHB14
L-fucose dehydrogenase

5

0

High-throughput

0.697

High

775414

EP300
Histone acetyltransferase p300

4

2

Small-scale

0.690

High

617201

ATF4
Cyclic AMP-dependent transcription factor ATF-4

4

1

Small-scale

0.687

High

775438

EMSY
BRCA2-interacting transcriptional repressor EMSY

3

1

High-throughput

0.675

High

775424

CEBPE
CCAAT/enhancer-binding protein epsilon

3

14

Small-scale

0.661

High

775440

TEDC1
Tubulin epsilon and delta complex protein 1

3

0

Small-scale

0.646

High

775468

MCMBP
Mini-chromosome maintenance complex-binding protein

3

0

High-throughput

0.639

High

429413

JUN
Transcription factor Jun

2

12

Small-scale

0.629

High

775415

DBP
D site-binding protein

2

16

High-throughput

0.619

High

605240

ATF7
Cyclic AMP-dependent transcription factor ATF-7

2

6

High-throughput

0.619

High

63173

VP37C
Vacuolar protein sorting-associated protein 37C

3

1

High-throughput

0.616

High

775421

PCM1
Pericentriolar material 1 protein

2

0

High-throughput

0.612

High

775450

JDP2
Jun dimerization protein 2

2

14

High-throughput

0.606

High

775425

NF2L2
Nuclear factor erythroid 2-related factor 2

1

8

Small-scale

0.603

High

166499

BACH1
Transcription regulator protein BACH1

2

2

High-throughput

0.602

High

230273

CREB3
Cyclic AMP-responsive element-binding protein 3

2

3

High-throughput

0.602

High

583483

ATF2
Cyclic AMP-dependent transcription factor ATF-2

2

6

High-throughput

0.602

High

603620

JUNB
Transcription factor JunB

2

6

High-throughput

0.602

High

775427

HLF
Hepatic leukemia factor

2

16

High-throughput

0.602

High

775429

NFIL3
Nuclear factor interleukin-3-regulated protein

2

12

High-throughput

0.602

High

775461

TRIB3
Tribbles homolog 3

2

0

Small-scale

0.598

High

219403

TNF12
Tumor necrosis factor ligand superfamily member 12

3

1

High-throughput

0.597

High

775402

CEBPD
CCAAT/enhancer-binding protein delta

2

16

Small-scale

0.595

High

227404

SPOP
Speckle-type POZ protein

2

0

Small-scale

0.588

High

775418

HDAC1
Histone deacetylase 1

2

1

Small-scale

0.584

High

251278

CRBL2
cAMP-responsive element-binding protein-like 2

2

0

High-throughput

0.580

High

775443

TXND2
Thioredoxin domain-containing protein 2

2

0

High-throughput

0.580

High

775448

LNX1
E3 ubiquitin-protein ligase LNX

2

0

High-throughput

0.580

High

775463

THIOM
Thioredoxin, mitochondrial

2

0

High-throughput

0.580

High

775467

EFC4B
EF-hand calcium-binding domain-containing protein 4B

2

0

High-throughput

0.580

High

605054

JUND
Transcription factor JunD

1

5

Small-scale

0.573

High

775400

DDIT3
DNA damage-inducible transcript 3 protein

2

0

High-throughput

0.560

High

296853

GABR2
Gamma-aminobutyric acid type B receptor subunit 2

1

1

Small-scale

0.552

High

299816

SNPC5
snRNA-activating protein complex subunit 5

1

0

High-throughput

0.549

High

664367

ZBT25
Zinc finger and BTB domain-containing protein 25

1

0

High-throughput

0.549

High

681761

RBTN2
Rhombotin-2

1

0

High-throughput

0.549

High

775430

DRC12
Dynein regulatory complex protein 12

1

0

High-throughput

0.549

High

775436

ZC3HE
Zinc finger CCCH domain-containing protein 14

1

0

High-throughput

0.549

High

775445

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

1

0

High-throughput

0.549

High

775483

AMOL2
Angiomotin-like protein 2

1

0

High-throughput

0.549

High

775407

RS3A
Small ribosomal subunit protein eS1

1

0

Small-scale

0.537

High

775422

MTFR1
Mitochondrial fission regulator 1

1

1

High-throughput

0.536

High

775442

TLK2
Serine/threonine-protein kinase tousled-like 2

1

1

High-throughput

0.536

High

775472

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

1

High-throughput

0.536

High

775480

TLK1
Serine/threonine-protein kinase tousled-like 1

1

1

High-throughput

0.536

High

658004

RS3
Small ribosomal subunit protein uS3

1

0

Small-scale

0.529

High

775410

CDK6
Cyclin-dependent kinase 6

1

0

Small-scale

0.527

High

366098

THRB
Prothrombin

1

0

High-throughput

0.518

High

634827

HXA5
Homeobox protein Hox-A5

1

0

High-throughput

0.518

High

775439

RAI1
Retinoic acid-induced protein 1

1

0

High-throughput

0.518

High

775460

ZSC31
Zinc finger and SCAN domain-containing protein 31

1

0

High-throughput

0.518

High

775465

SSX3
Protein SSX3

1

0

High-throughput

0.518

High

775485

NEMO
NF-kappa-B essential modulator

1

0

High-throughput

0.518

High

775408

CSK21
Casein kinase II subunit alpha

1

0

Small-scale

0.513

High

171189

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

0

High-throughput

0.513

High

775413

HSF2
Heat shock factor protein 2

1

0

High-throughput

0.513

High

775484

RBGP1
Rab GTPase-activating protein 1

1

0

High-throughput

0.513

High

193331

MAFG
Transcription factor MafG

1

1

High-throughput

0.501

High

584002

FOSL1
Fos-related antigen 1

1

13

High-throughput

0.501

High

775444

BATF2
Basic leucine zipper transcriptional factor ATF-like 2

1

2

High-throughput

0.501

High

775458

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

1

7

High-throughput

0.501

High

775469

BACH2
Transcription regulator protein BACH2

1

2

High-throughput

0.501

High

775481

MAFF
Transcription factor MafF

1

1

High-throughput

0.501

High

570368

GFAP
Glial fibrillary acidic protein

1

0

High-throughput

0.493

High

775434

MTFR2
Mitochondrial fission regulator 2

1

1

High-throughput

0.489

High

167578

GIPC1
PDZ domain-containing protein GIPC1

1

0

Small-scale

0.486

High

775428

MK14
Mitogen-activated protein kinase 14

1

0

Small-scale

0.480

High

775464

EPAS1
Endothelial PAS domain-containing protein 1

1

0

High-throughput

0.480

High

775471

SRA1
Steroid receptor RNA activator 1

1

0

Small-scale

0.480

High

775479

DNM3L
DNA

1

0

Small-scale

0.480

High

154636

ARI1A
AT-rich interactive domain-containing protein 1A

1

1

Small-scale

0.479

High

774884

FUS
RNA-binding protein FUS

1

2

Small-scale

0.479

High

775403

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

1

Small-scale

0.479

High

775404

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

1

Small-scale

0.479

High

775412

EWS
RNA-binding protein EWS

1

2

Small-scale

0.479

High

775419

CUL1
Cullin-1

1

1

Small-scale

0.479

High

775420

CUL3
Cullin-3

1

1

Small-scale

0.479

High

775423

SSXT
Protein SSXT

1

2

Small-scale

0.479

High

775432

ARID2
AT-rich interactive domain-containing protein 2

1

1

Small-scale

0.479

High

775437

SMRD3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

1

2

Small-scale

0.479

High

775441

PB1
Protein polybromo-1

1

2

Small-scale

0.479

High

775446

ARI1B
AT-rich interactive domain-containing protein 1B

1

2

Small-scale

0.479

High

775447

SMRC2
SWI/SNF complex subunit SMARCC2

1

1

Small-scale

0.479

High

775451

DPF3
Zinc finger protein DPF3

1

1

Small-scale

0.479

High

775452

REQU
Zinc finger protein ubi-d4

1

1

Small-scale

0.479

High

775453

CBP
CREB-binding protein

1

2

Small-scale

0.479

High

775454

RBP56
TATA-binding protein-associated factor 2N

1

2

Small-scale

0.479

High

775455

SMRC1
SWI/SNF complex subunit SMARCC1

1

1

Small-scale

0.479

High

775456

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

2

Small-scale

0.479

High

775459

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

2

Small-scale

0.479

High

775476

HDAC6
Protein deacetylase HDAC6

1

2

Small-scale

0.479

High

775477

GABR1
Gamma-aminobutyric acid type B receptor subunit 1

1

1

Small-scale

0.479

High

775482

HDAC5
Histone deacetylase 5

1

2

Small-scale

0.479

High

775431

Q4ACW9
Tumor necrosis factor ligand superfamily member 12

1

1

High-throughput

0.470

High

456966

GP1BA
Platelet glycoprotein Ib alpha chain

1

0

High-throughput

0.460

High

775405

IMA1
Importin subunit alpha-1

1

0

High-throughput

0.460

High

775435

GIMA6
GTPase IMAP family member 6

1

0

High-throughput

0.460

High

187477

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.458

High

294664

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

Small-scale

0.458

High

330710

KI20A
Kinesin-like protein KIF20A

1

0

High-throughput

0.458

High

355149

ACL6A
Actin-like protein 6A

1

0

Small-scale

0.458

High

442618

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.458

High

534715

BIP
Endoplasmic reticulum chaperone BiP

1

0

Small-scale

0.458

High

656055

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

0

Small-scale

0.458

High

775411

E2F1
Transcription factor E2F1

1

0

Small-scale

0.458

High

775416

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

Small-scale

0.458

High

775417

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

Small-scale

0.458

High

775457

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

0

Small-scale

0.458

High

775462

CSN8
COP9 signalosome complex subunit 8

1

0

Small-scale

0.458

High

775470

ATG5
Autophagy protein 5

1

0

Small-scale

0.458

High

775473

MLXPL
Carbohydrate-responsive element-binding protein

1

0

Small-scale

0.458

High

775474

IL23A
Interleukin-23 subunit alpha

1

0

Small-scale

0.458

High

775478

CSN7A
COP9 signalosome complex subunit 7a

1

0

Small-scale

0.458

High

516821

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.438

High

775433

RTL6
Retrotransposon Gag-like protein 6

2

0

High-throughput

0.328

High

775409

IDD
Integral membrane protein DGCR2/IDD

1

0

High-throughput

0.282

High

775449

JPH3
Junctophilin-3

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025