HitPredict

Interactor 1: SI1L3 (O60292)
Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3)
Gene: SIPA1L3

Interactor 2: ZO2 (Q9UDY2)
Tight junction protein ZO-2 (Tight junction protein 2) (Zona occludens protein 2) (Zonula occludens protein 2)
Gene: TJP2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, PDZ~PDZ, PDZ~SH3_2
Common GO terms	GO:0005654 - nucleoplasm GO:0005886 - plasma membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1781 Hs			1 1190
+	Hs
		196521 SI1L1_HUMAN (3-1774): 0: 1211: 45.79		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		230241 SI1L3_HUMAN (1-1781): 0: 1374: 100.00		ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80
+	Hs
		196434 SI1L1_HUMAN (3-1774): 0: 1211: 45.79		ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80
+	Hs
		196430 SI1L1_HUMAN (3-1774): 0: 1211: 45.79		DLG4_HUMAN (3-423): 2.31e-52: 199: 18.89
+	Mm
		1143412 SI1L1_MOUSE (3-1774): 0: 1206: 46.26		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Hs
		1255142 DLG5_HUMAN (1042-1430): 3.08e-09: 64.4: 9.23		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		1102434 RGPA2_HUMAN (361-868): 3.58e-125: 437: 17.93		DLG3_HUMAN (2-318): 5.99e-23: 107: 16.61
+	Hs
		990892 DLG5_HUMAN (1042-1430): 3.08e-09: 64.4: 9.23		ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80
+	Hs
		1151770 RGPA1_HUMAN (327-850): 4.76e-106: 379: 18.68		DLG3_HUMAN (2-318): 5.99e-23: 107: 16.61
+	Ce
		105545 H2L055_CAEEL (491-887): 2.84e-120: 401: 35.26		DLG1_CAEEL (339-611): 2.49e-14: 80.2: 14.98
+	Mm
		1143433 SYNJ1_MOUSE (1350-1764): 1.35e-09: 65.5: 12.33		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Ce
		103468 TTN1_CAEEL (985-1749): 6.14e-28: 126: 10.03		DLG1_CAEEL (339-611): 2.49e-14: 80.2: 14.98