HitPredict

Interactor 1: PHLP1 (O60346)
PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP)
Gene: PHLPP1

Interactor 2: SNX27 (Q96L92)
Sorting nexin-27
Gene: SNX27

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.839

Property	Details
Experiments	34315543, 33397691, 19615732
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PX, PH~RA
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1717 Hs			1 541
+	Hs
		232891 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		NHRF2_HUMAN (9-207): 1.8e-24: 106: 21.78
+	Hs
		153848 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		NHRF1_HUMAN (12-209): 7.91e-23: 101: 22.89
+	Hs
		232854 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		ZO1_HUMAN (4-254): 7.48e-12: 70.3: 13.97
+	Hs
		1172965 PHLP2_HUMAN (469-1717): 0: 884: 53.15		SNX27_HUMAN (1-541): 0: 625: 100.00
+	Hs
		1075423 PHLP2_HUMAN (469-1717): 0: 884: 53.15		NHRF2_HUMAN (9-207): 1.8e-24: 106: 21.78
+	Hs
		153932 PHLP2_HUMAN (469-1717): 0: 884: 53.15		NHRF1_HUMAN (12-209): 7.91e-23: 101: 22.89
+	Hs
		1130458 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		SNX27_HUMAN (1-541): 0: 625: 100.00
+	Hs
		1296886 LRRC1_HUMAN (896-1143): 8.91e-09: 62: 28.74		SNX27_HUMAN (1-541): 0: 625: 100.00
+	Dm
		677695 SCRIB_DROME (739-1116): 5.3e-16: 86.7: 28.29		DLG1_DROME (44-160): 1.73e-12: 72.3: 19.49