HitPredict

Interactor 1: PEPL (O60437)
Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)
Gene: PPL

Interactor 2: K2C8 (P05787)
Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8)
Gene: KRT8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	0.60	0.527

Property	Details
Experiments	12366696
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005882 - intermediate filament GO:0031424 - keratinization GO:0070062 - extracellular exosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1756 Hs			1 483
+	Hs
		444536 GOGA4_HUMAN (2-1336): 6.16e-43: 175: 9.40		K2C7_HUMAN (1-464): 4.13e-154: 448: 60.34
+	Hs
		580132 NUMA1_HUMAN (2-783): 1.46e-15: 85.3: 10.87		K2C4_HUMAN (55-420): 5.63e-110: 337: 61.96
+	Hs
		821662 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		K2C6C_HUMAN (56-405): 2.63e-66: 225: 70.74
+	Hs
		409080 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		K2C8_HUMAN (1-483): 2.44e-63: 215: 100.00
+	Hs
		318809 NUMA1_HUMAN (2-783): 1.46e-15: 85.3: 10.87		K2C75_HUMAN (2-405): 3.9e-79: 258: 64.04
+	Hs
		408987 MYH1_HUMAN (1062-1756): 6.26e-27: 122: 12.25		K2C8_HUMAN (1-483): 2.44e-63: 215: 100.00
+	Hs
		1061108 NUMA1_HUMAN (2-783): 1.46e-15: 85.3: 10.87		K2C72_HUMAN (10-405): 1.57e-71: 237: 58.33
+	Hs
		531529 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		K2C5_HUMAN (56-405): 9.54e-66: 223: 71.02
+	Hs
		359462 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		K2C6A_HUMAN (56-405): 8.09e-65: 220: 70.74
+	Hs
		408995 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		K2C8_HUMAN (1-483): 2.44e-63: 215: 100.00