HitPredict

Interactor 1: PEPL (O60437)
Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)
Gene: PPL

Interactor 2: SYNCI (Q9H7C4)
Syncoilin (Syncoilin intermediate filament 1) (Syncoilin-1)
Gene: SYNC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005882 - intermediate filament
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1756 Hs			1 482
+	Hs
		234175 PEPL_HUMAN (1-1756): 3.44e-127: 441: 100.00		VIME_HUMAN (154-456): 2.16e-104: 321: 21.70
+	Mm
		589655 PEPL_MOUSE (1-1756): 6.37e-116: 408: 87.48		VIME_MOUSE (154-456): 8.23e-104: 319: 21.70
+	Hs
		234188 PEPL_HUMAN (1-1756): 3.44e-127: 441: 100.00		DESM_HUMAN (154-456): 6.3e-86: 273: 20.76
+	Hs
		1313530 CP250_HUMAN (1-1328): 4.6e-43: 175: 11.06		SYNCI_HUMAN (1-482): 9.08e-167: 481: 100.00
+	Hs
		443532 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		VIME_HUMAN (154-456): 2.16e-104: 321: 21.70
+	Hs
		1068542 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		AINX_HUMAN (170-456): 1.08e-91: 289: 25.25
+	Hs
		781898 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		PERI_HUMAN (154-456): 6.88e-79: 255: 22.50
+	Mm
		677677 PLEC_MOUSE (2-1071): 1.05e-33: 145: 10.58		DESM_MOUSE (154-456): 2.87e-88: 279: 20.76
+	Hs
		443504 SPTN1_HUMAN (4-1191): 1.92e-18: 94.9: 10.52		VIME_HUMAN (154-456): 2.16e-104: 321: 21.70
+	Hs
		443305 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		VIME_HUMAN (154-456): 2.16e-104: 321: 21.70
+	Hs
		821662 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		K2C6C_HUMAN (133-481): 3.14e-63: 216: 16.89
+	Hs
		535318 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		GFAP_HUMAN (154-456): 5.8e-99: 306: 23.27
+	Hs
		569077 SPTN1_HUMAN (4-1191): 1.92e-18: 94.9: 10.52		DESM_HUMAN (154-456): 6.3e-86: 273: 20.76
+	Hs
		551603 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		DESM_HUMAN (154-456): 6.3e-86: 273: 20.76
+	Hs
		318809 NUMA1_HUMAN (2-783): 1.46e-15: 85.3: 10.87		K2C75_HUMAN (133-477): 2.66e-77: 253: 16.80
+	Hs
		580132 NUMA1_HUMAN (2-783): 1.46e-15: 85.3: 10.87		K2C4_HUMAN (141-481): 3.59e-77: 252: 15.04
+	Hs
		551630 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		PERI_HUMAN (154-456): 6.88e-79: 255: 22.50
+	Hs
		1061108 NUMA1_HUMAN (2-783): 1.46e-15: 85.3: 10.87		K2C72_HUMAN (142-466): 1.04e-65: 221: 16.04
+	Hs
		531529 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		K2C5_HUMAN (133-473): 1.55e-63: 218: 16.71
+	Hs
		359462 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		K2C6A_HUMAN (133-481): 3.92e-61: 211: 17.44