Protein: PLS1
Phospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependent phospholipid scramblase 1) (Erythrocyte phospholipid scramblase) (Mg(2+)-dependent nuclease) (EC 3.1.-.-) (MmTRA1b)

Gene: PLS1, PLSCR1
Organism: Homo sapiens
Interactions: 178
UniProt ID: O15162

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001618 - virus receptor activity
GO:0003677 - DNA binding
GO:0004518 - nuclease activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

180564

ESR2
Estrogen receptor beta

3

3

High-throughput

0.690

High

180456

GLRX3
Glutaredoxin-3

2

1

High-throughput

0.646

High

180519

DAZP2
DAZ-associated protein 2

2

1

High-throughput

0.646

High

180576

CLCC1
Chloride channel CLIC-like protein 1

3

0

High-throughput

0.634

High

180595

REEP1
Receptor expression-enhancing protein 1

2

2

High-throughput

0.628

High

180508

EWS
RNA-binding protein EWS

2

0

High-throughput

0.618

High

180467

HRG
Histidine-rich glycoprotein

2

2

High-throughput

0.614

High

180469

A4
Amyloid-beta precursor protein

2

2

High-throughput

0.611

High

180531

TM128
Transmembrane protein 128

2

1

High-throughput

0.611

High

180607

GDE1
Glycerophosphodiester phosphodiesterase 1

2

1

High-throughput

0.611

High

180496

ANX11
Annexin A11

2

2

High-throughput

0.608

High

180601

PLS4
Phospholipid scramblase 4

2

4

High-throughput

0.608

High

180493

RGS3
Regulator of G-protein signaling 3

2

0

High-throughput

0.601

High

180582

SCNM1
Sodium channel modifier 1

2

0

High-throughput

0.601

High

180485

SHC1
SHC-transforming protein 1

2

0

Small-scale

0.598

High

180524

CRY1
Cryptochrome-1

2

0

High-throughput

0.587

High

180516

MVP
Major vault protein

2

1

High-throughput

0.584

High

180505

S35A2
UDP-galactose translocator

2

0

High-throughput

0.582

High

180558

CCER1
Coiled-coil domain-containing glutamate-rich protein 1

2

0

High-throughput

0.582

High

180507

REEP5
Receptor expression-enhancing protein 5

2

2

High-throughput

0.574

High

63153

VP37C
Vacuolar protein sorting-associated protein 37C

1

2

High-throughput

0.573

High

180454

STK16
Serine/threonine-protein kinase 16

1

1

High-throughput

0.573

High

180501

KR109
Keratin-associated protein 10-9

1

12

High-throughput

0.573

High

180520

P2RY6
P2Y purinoceptor 6

1

3

High-throughput

0.573

High

180538

LEG9C
Galectin-9C

1

7

High-throughput

0.573

High

180548

TRI42
Tripartite motif-containing protein 42

1

7

High-throughput

0.573

High

180556

CTSR1
Cation channel sperm-associated protein 1

1

1

High-throughput

0.573

High

180557

ZN417
Zinc finger protein 417

1

1

High-throughput

0.573

High

180567

SMRC1
SWI/SNF complex subunit SMARCC1

1

2

High-throughput

0.573

High

180577

ZN587
Zinc finger protein 587

1

1

High-throughput

0.573

High

180583

KRA92
Keratin-associated protein 9-2

1

10

High-throughput

0.573

High

180584

KR411
Keratin-associated protein 4-11

1

11

High-throughput

0.573

High

180585

KRA42
Keratin-associated protein 4-2

1

11

High-throughput

0.573

High

180592

DEFI6
Differentially expressed in FDCP 6 homolog

1

1

High-throughput

0.573

High

180599

DMRT3
Doublesex- and mab-3-related transcription factor 3

1

2

High-throughput

0.573

High

180606

PRR13
Proline-rich protein 13

1

2

High-throughput

0.573

High

180513

ILF3
Interleukin enhancer-binding factor 3

2

0

High-throughput

0.559

High

180526

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.558

High

180544

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.558

High

180561

NEUR4
Sialidase-4

1

0

High-throughput

0.558

High

180565

TFG
Protein TFG

1

0

High-throughput

0.558

High

180451

FRS3
Fibroblast growth factor receptor substrate 3

1

0

High-throughput

0.549

High

180515

PKD2
Polycystin-2

1

0

High-throughput

0.549

High

180539

KRA56
Keratin-associated protein 5-6

1

0

High-throughput

0.549

High

180563

DOCK2
Dedicator of cytokinesis protein 2

1

0

High-throughput

0.549

High

180611

CATZ
Cathepsin Z

1

0

High-throughput

0.549

High

180459

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

1

9

High-throughput

0.541

High

180477

HXB6
Homeobox protein Hox-B6

1

1

High-throughput

0.541

High

180482

CNTFR
Ciliary neurotrophic factor receptor subunit alpha

1

4

High-throughput

0.541

High

180487

HXA9
Homeobox protein Hox-A9

1

5

High-throughput

0.541

High

180489

CRK
Adapter molecule crk

1

1

High-throughput

0.541

High

180492

HXA1
Homeobox protein Hox-A1

1

5

High-throughput

0.541

High

180494

MCSP
Sperm mitochondrial-associated cysteine-rich protein

1

1

High-throughput

0.541

High

180498

ATN1
Atrophin-1

1

2

High-throughput

0.541

High

180504

PITX1
Pituitary homeobox 1

1

3

High-throughput

0.541

High

180510

ZBT16
Zinc finger and BTB domain-containing protein 16

1

1

High-throughput

0.541

High

180512

KIF1A
Kinesin-like protein KIF1A

1

1

High-throughput

0.541

High

180534

INT11
Integrator complex subunit 11

1

1

High-throughput

0.541

High

180542

DLK2
Protein delta homolog 2

1

2

High-throughput

0.541

High

180543

ATL4
ADAMTS-like protein 4

1

4

High-throughput

0.541

High

180571

ZN764
Zinc finger protein 764

1

1

High-throughput

0.541

High

180575

MED15
Mediator of RNA polymerase II transcription subunit 15

1

4

High-throughput

0.541

High

180579

KR412
Keratin-associated protein 4-12

1

12

High-throughput

0.541

High

180580

RAMAC
RNA guanine-N7 methyltransferase activating subunit

1

1

High-throughput

0.541

High

180596

NET4
Netrin-4

1

4

High-throughput

0.541

High

180598

ARNT2
Aryl hydrocarbon receptor nuclear translocator 2

1

2

High-throughput

0.541

High

180602

PLS3
Phospholipid scramblase 3

1

4

High-throughput

0.541

High

180608

ZN581
Zinc finger protein 581

1

1

High-throughput

0.541

High

180609

RERE
Arginine-glutamic acid dipeptide repeats protein

1

2

High-throughput

0.541

High

180615

RASD1
Dexamethasone-induced Ras-related protein 1

1

1

High-throughput

0.541

High

165859

FFAR1
Free fatty acid receptor 1

1

5

High-throughput

0.536

High

167144

T4S5
Transmembrane 4 L6 family member 5

1

1

High-throughput

0.536

High

180471

CD63
CD63 antigen

1

4

High-throughput

0.536

High

180473

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

2

High-throughput

0.536

High

180481

NK1R
Substance-P receptor

1

1

High-throughput

0.536

High

180488

CNR2
Cannabinoid receptor 2

1

3

Small-scale

0.536

High

180514

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

3

High-throughput

0.536

High

180572

REEP6
Receptor expression-enhancing protein 6

1

2

High-throughput

0.536

High

180465

SLPI
Antileukoproteinase

1

0

Small-scale

0.529

High

180535

LCE4A
Late cornified envelope protein 4A

1

1

High-throughput

0.523

High

180536

LCE2D
Late cornified envelope protein 2D

1

2

High-throughput

0.523

High

180590

CHRD
Chordin

1

8

High-throughput

0.523

High

180452

SPY2
Protein sprouty homolog 2

1

0

High-throughput

0.518

High

180453

GRIN2
G protein-regulated inducer of neurite outgrowth 2

1

0

High-throughput

0.518

High

180457

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.518

High

180468

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

0

High-throughput

0.518

High

180474

ADT3
ADP/ATP translocase 3

1

0

High-throughput

0.518

High

180495

VASP
Vasodilator-stimulated phosphoprotein

1

0

High-throughput

0.518

High

180506

BORG5
Cdc42 effector protein 1

1

0

High-throughput

0.518

High

180509

ODO1
2-oxoglutarate dehydrogenase complex component E1

1

0

High-throughput

0.518

High

180517

LASP1
LIM and SH3 domain protein 1

1

0

High-throughput

0.518

High

180518

ZN638
Zinc finger protein 638

1

0

High-throughput

0.518

High

180522

SF01
Splicing factor 1

1

0

High-throughput

0.518

High

180545

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

0

High-throughput

0.518

High

180560

PHLA1
Pleckstrin homology-like domain family A member 1

1

0

High-throughput

0.518

High

180581

NOC4L
Nucleolar complex protein 4 homolog

1

0

High-throughput

0.518

High

180586

YIPF3
Protein YIPF3

1

0

High-throughput

0.518

High

180587

IQCN
IQ domain-containing protein N

1

0

High-throughput

0.518

High

180588

ENKD1
Enkurin domain-containing protein 1

1

0

High-throughput

0.518

High

180594

VISTA
V-type immunoglobulin domain-containing suppressor of T-cell activation

1

0

High-throughput

0.518

High

180600

NPDC1
Neural proliferation differentiation and control protein 1

1

0

High-throughput

0.518

High

180603

DEPP1
Protein DEPP1

1

0

High-throughput

0.518

High

180604

NECP2
Adaptin ear-binding coat-associated protein 2

1

0

High-throughput

0.518

High

180610

HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2

1

0

High-throughput

0.518

High

180613

IP6K2
Inositol hexakisphosphate kinase 2

1

0

High-throughput

0.518

High

180614

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

1

0

High-throughput

0.518

High

69884

A8KA13
B-cell CLL/lymphoma 6 member B protein

1

2

High-throughput

0.515

High

180502

KR10B
Keratin-associated protein 10-11

1

12

High-throughput

0.515

High

180449

COPT2
Protein SLC31A2

1

0

High-throughput

0.513

High

180455

PRAF3
PRA1 family protein 3

1

0

High-throughput

0.513

High

180491

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

0

High-throughput

0.513

High

180499

IOD3
Thyroxine 5-deiodinase

1

0

High-throughput

0.513

High

180537

STUM
Protein stum homolog

1

0

High-throughput

0.513

High

180570

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.513

High

180578

SGMR1
Sigma non-opioid intracellular receptor 1

1

0

High-throughput

0.513

High

180490

CRKL
Crk-like protein

1

1

High-throughput

0.508

High

180527

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.508

High

180476

SRC
Proto-oncogene tyrosine-protein kinase Src

1

1

Small-scale

0.501

High

141773

MFNG
Beta-1,3-N-acetylglucosaminyltransferase manic fringe

1

1

High-throughput

0.489

High

180470

TSP1
Thrombospondin-1

1

7

Small-scale

0.481

High

180472

ZN688
Zinc finger protein 688

1

3

High-throughput

0.481

High

180480

FBLN1
Fibulin-1

1

6

High-throughput

0.481

High

180483

RXRB
Retinoic acid receptor RXR-beta

1

4

High-throughput

0.481

High

180486

PML
Protein PML

1

3

High-throughput

0.481

High

180497

ADCY7
Adenylate cyclase type 7

1

5

High-throughput

0.481

High

180500

KR103
Keratin-associated protein 10-3

1

12

High-throughput

0.481

High

180511

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.481

High

180521

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

1

High-throughput

0.481

High

180529

LONF1
LON peptidase N-terminal domain and RING finger protein 1

1

5

High-throughput

0.481

High

180551

BCL6B
B-cell CLL/lymphoma 6 member B protein

1

2

High-throughput

0.481

High

180559

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

1

High-throughput

0.481

High

133707

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

1

High-throughput

0.479

High

180450

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

180461

EGFR
Epidermal growth factor receptor

1

1

Small-scale

0.479

High

180462

RASN
GTPase NRas

1

8

High-throughput

0.479

High

180463

RASH
GTPase HRas

1

8

High-throughput

0.479

High

180464

RASK
GTPase KRas

1

8

High-throughput

0.479

High

180466

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

180475

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

180478

EGR1
Early growth response protein 1

1

1

High-throughput

0.479

High

180503

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.479

High

180458

6PGL
6-phosphogluconolactonase

1

0

High-throughput

0.460

High

180460

F107A
Actin-associated protein FAM107A

1

0

Small-scale

0.460

High

180484

RBL1
Retinoblastoma-like protein 1

1

0

High-throughput

0.460

High

180530

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

1

0

High-throughput

0.460

High

180549

DDIAS
DNA damage-induced apoptosis suppressor protein

1

0

Small-scale

0.460

High

180566

FRAT1
Proto-oncogene FRAT1

1

0

High-throughput

0.460

High

180574

FXL18
F-box/LRR-repeat protein 18

1

0

High-throughput

0.460

High

180525

OCLN
Occludin

1

0

Small-scale

0.458

High

180553

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

0

Small-scale

0.458

High

3518

A0A0S2Z5X4
Zinc finger protein 688 isoform 4

1

3

High-throughput

0.457

High

180617

X5D7R7
Major vault protein

1

1

High-throughput

0.457

High

180618

X5DP31
Aryl hydrocarbon receptor nuclear translocator 2

1

3

High-throughput

0.457

High

85138

B7Z3K1
cDNA FLJ51973

1

1

High-throughput

0.445

High

180523

S15A2
Solute carrier family 15 member 2

1

4

High-throughput

0.445

High

180541

S22AP
Solute carrier family 22 member 25

1

4

High-throughput

0.445

High

180550

S35F2
Solute carrier family 35 member F2

1

0

High-throughput

0.426

High

180547

S22A9
Organic anion transporter 7

1

4

High-throughput

0.407

High

180546

RETR3
Reticulophagy regulator 3

4

0

High-throughput

0.360

High

180528

RTN1
Reticulon-1

2

0

High-throughput

0.328

High

180593

SPRNG
SREBP regulating gene protein

2

0

High-throughput

0.328

High

180612

FA8A1
Protein FAM8A1

2

0

High-throughput

0.328

High

180616

BOLA1
BolA-like protein 1

2

0

High-throughput

0.328

High

180605

Q9NXX0
ILF3 protein

2

0

High-throughput

0.311

High

180540

SPAT8
Spermatogenesis-associated protein 8

1

0

High-throughput

0.299

High

180479

MK
Midkine

1

0

Small-scale

0.292

High

180532

LCE3C
Late cornified envelope protein 3C

1

0

High-throughput

0.292

High

180533

CJ062
Uncharacterized protein C10orf62

1

0

High-throughput

0.282

High

180552

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.282

High

180555

MUT7
Exonuclease mut-7 homolog

1

0

High-throughput

0.282

High

180573

DHRS1
Dehydrogenase/reductase SDR family member 1

1

0

High-throughput

0.282

High

180589

PED1A
PC-esterase domain-containing protein 1A

1

0

High-throughput

0.282

High

180554

KTAP2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2

1

0

High-throughput

0.279

Low

180562

F168A
Protein FAM168A

1

0

High-throughput

0.279

Low

180597

Q9HBR3
GDPD5 protein

1

0

High-throughput

0.268

Low

180591

PPDPF
Pancreatic progenitor cell differentiation and proliferation factor

1

0

Small-scale

0.251

Low

180568

Q96CW7
C4orf42 protein

1

0

High-throughput

0.238

Low

180569

Q96D16
FBXL18 protein

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025